Lutheran

Question 1

Lutheran gene location

Answer 1

Chromosome 19

Linked to Se gene

Question 2

Lutheran low prevalence antigens

Answer 2

Lu9 and Lu14

Question 3

Lu(a+b-) prevalence

Answer 3

0.2%

Question 4

Lu(a+b+) prevalence

Answer 4

7.4%

Question 5

Lu(a-b+) prevalence

Answer 5

92.4%

Question 6

Lu(a-b-) prevalence

Answer 6

Rare

Question 7

Recessive Lu(a-b-)

Answer 7

Requires inheritance of 2 recessive Lu genes

True null- do not express Lu a or b

Make anti-Lu3

Question 8

Autosomal dominant Lu(a-b-)

Answer 8

Inheritance of a dominant inhibitor, usually In(Lu)

Trace amounts of antigen present detectable by adsorption/elution

Don’t make anti-Lu3

Question 9

X-linked Lu(a-b-) aka Lu mod

Answer 9

X linked- affects males, females are carriers
Rare-only 1 family

Very weak antigen expression

Don’t make anti-Lu3

Question 10

Lutheran antibodies

Answer 10

Loose mixed field agglutination

Most often IgG but can be M or A

No HDFN

rarely cause transfusion reactions

Inconsistent reactions of anti-Lub between cells do to variable antigen expression

Question 11

Lutheran antigen with enzyme treatment

Answer 11

Resistant

Question 12

Lutheran antigen with DTT/AET treatment

Answer 12

Destroyed

Question 13

Lutheran antigen with trypsin or a-chymotrypsin

Answer 13

Destroyed

Question 14

Lutheran antigens with papain and ficin

Answer 14

Little effect

Question 15

Lutheran glycoproteins purpose

Answer 15

Adhesion molecules that bind isoforms of laminin

May play a role in migration of mature erythroids from the marrow

Upregulatuon in sickle cell disease could play a part in cells adhesion to the vascular endothelium and occlusive crisis

Question 16

Lu (a-b-) inhibitor phenotype also has decreased expression of

Answer 16

P1
In^b
AnWj