HLA Flashcards
Soluble levels of HLA increase in
Infection
Soluble levels of HLA decrease in
Malignancy
Soluble HLA in blood components
Proportional to number of residual donor lymphocytes and duration of storage
Public antigens
Common amino acid sequences in many HLA specificities
Ex HLA-Bw4 and -Bw6 (present in almost all HLA-B molecules)
Class I function
Presents endogenous protein- inserted in endoplasmic reticulum
Interact with CD8+ T cells
Class II function
Presents exogenous proteins that are taken up by endocytosis
Interact with CD4+ cells
Class I expression
Present on most nucleated cells
Except neurons, corneal epithelial cells, trophiblasts, and germinal cells
Class II expression
B lymphocytes Dendritic cells Intestinal epithelium Early hematopoietic cells Activated T lymphocytes
HLA disease association
DR4
Rheumatoid arthritis
HLA disease association
DR15/ DQ6
MS
HLA disease association
B27
Ankylosing spondylitis
HLA disease association
DR17
Graves’ disease
HLA disease association
DQ2
Celiac disease
HLA disease association
DQ6
Narcolepsy
HLA disease association
B35
Subacute thyroiditis