HLA Flashcards

1
Q

Soluble levels of HLA increase in

A

Infection

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2
Q

Soluble levels of HLA decrease in

A

Malignancy

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3
Q

Soluble HLA in blood components

A

Proportional to number of residual donor lymphocytes and duration of storage

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4
Q

Public antigens

A

Common amino acid sequences in many HLA specificities

Ex HLA-Bw4 and -Bw6 (present in almost all HLA-B molecules)

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5
Q

Class I function

A

Presents endogenous protein- inserted in endoplasmic reticulum

Interact with CD8+ T cells

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6
Q

Class II function

A

Presents exogenous proteins that are taken up by endocytosis

Interact with CD4+ cells

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7
Q

Class I expression

A

Present on most nucleated cells

Except neurons, corneal epithelial cells, trophiblasts, and germinal cells

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8
Q

Class II expression

A
B lymphocytes
Dendritic cells
Intestinal epithelium 
Early hematopoietic cells
Activated T lymphocytes
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9
Q

HLA disease association

DR4

A

Rheumatoid arthritis

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10
Q

HLA disease association

DR15/ DQ6

A

MS

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11
Q

HLA disease association

B27

A

Ankylosing spondylitis

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12
Q

HLA disease association

DR17

A

Graves’ disease

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13
Q

HLA disease association

DQ2

A

Celiac disease

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14
Q

HLA disease association

DQ6

A

Narcolepsy

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15
Q

HLA disease association

B35

A

Subacute thyroiditis

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16
Q

HLA disease association

DQ8

A

Type 1 diabetes

17
Q

HLA disease association

DR8

A

Juvenile rheumatoid arthritis