Granulocyte Antigens Flashcards

1
Q

HNA-1a/1b/1c/1d location

A

FcÿRIIIb (CD16b)

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2
Q

HNA-2 location

A

CD177

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3
Q

antibodies to HNA-2

A

Made by people missing the whole CD177 protein (1-11%)

Implicated in NAN, TRALI, AIN, and neutropenia in marrow transplant recipients

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4
Q

Location of HNA-3a/3b

A

CTL2 (choline transporter like protein 2)

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5
Q

Antibodies to HNA-3a

A

Most frequent cause of fatal TRALI

Also cause febrile reactions and NAN

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6
Q

HNA-4a/4b location

A

CD11b/18 (plays a role in neutrophil adhesion to endothelial cells and phagocytosis of C3bi opsonized microbes)

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7
Q

Location of HNA-5a

A

CD11a/18

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8
Q

Neutrophil expression of ABO and HLA

A

Do NOT express ABO antigens

Express HLA in modest amounts only upon activation (Class I and II)

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9
Q

Antibodies most frequently associated with NAN

A

HNA-1a, HNA-1b, HNA-2

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10
Q

Antibodies most often associated with AIN

A

HNA-1a (occasionally -1b or -4a)

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11
Q

Granulocyte antigen/antibody testing considerations

A

Granulocytes for testing must be isolated from fresh blood on day of testing (integrity is not maintained in stored samples at any temp)

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