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SBB Review > Other Blood Group Systems > Flashcards

Other Blood Group Systems Flashcards

1
Q

GPI linked glycoprotein on acetylcholinesterase

A

Yt

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2
Q

Yt antigens

A

Yta- high prevalence in all pop.
Ytb- 8% except in israeli’s where it can be up to 26%

No known null phenotype

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3
Q

Yta antigen w/ enzyme or DTT treatment

A

Destroyed

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4
Q

Yt antibodies

A

Usually IgG

No HDFN

anti-yta may cause HTR

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5
Q

Yta with trypsin and a-chymotrypsin

A

Trypsin-not effected

A-chymptrypsin- destroyed

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6
Q

XG blood group antigens

A

Xga and CD99

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7
Q

XG gene locations

A

XG : Xp22.32 tip of the short arm- not inactivated by lyonization

CD99 gene is on both X and Y chromosome

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8
Q

Xga prevalence

A

66% males

89% females

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9
Q

Anti-Xga

A

Usually IgG reactivity at IAT

Not considered clinically significant

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10
Q

Xga with ficin

A

Sensitive

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11
Q

Xga with DTT/AET

A

Resistant

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12
Q

Colton antigens

A

Co^a, Co^b, Co3, Co4

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13
Q

High prevalence Colton antigens

A

Co^a, Co3, Co4

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14
Q

Co^b prevalence

A

10%

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15
Q

Colton antigen location

A

Aquaporin-1 (red cell water transporter)

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16
Q

Colton gene location

A

Chromosome 7p14

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17
Q

Colton antibodies

A

usually IgG

Implicated in HDFN and HTRs

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18
Q

Colton antigen with proteolytic enzymes

A

Resistant

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19
Q

Anti-Co3

A

Made by rare Co(a-b-) phenotypes caused by various inactivating mutations

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20
Q

Co4

A

Required for Co^a expression

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21
Q

Gerbrich high prevalence antigens (6)

A

Ge2, Ge3, Ge4, GEPL, GEAT, GETI

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22
Q

Gerbrich low prevalence antigens (5)

A

Wb, Ls^a, An^a, Dh^a, GEIS

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23
Q

Gerbrich antigen locations

A

GPC and GPD- part of a junctional complex of membrane proteins that interact with protein 4.1 and p55 that help link membrane and it’s skeleton for membrane stability

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24
Q

Gerbrich gene location

A

Chromosome 2q14-21

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25
Q

GPC receptor for what parasite/virus

A

Plasmodium falciparum

Influenza A and B

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26
Q

Gerbrich null

A

Ge:-2,-3,-4

Both GPC and GPD absent

Cells are eliptocytes

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27
Q

Yus phenotype

A

Ge:-2,3,4

Make anti-Ge2

No depression of Kell/Vel antigens

Lack GPD with altered GPC

28
Q

Gerbich phenotype

A

Ge:-2,-3,4

Make anti-Ge2 and/or -Ge3

Weakened Kell/Vel expression

Lack GPD with altered GPC

29
Q

Leach phenotype

A

Ge:-2,-3,-4

Make antibodies to all

Decreased Kell/Vel expression

Lack GPC and GPD

Elliptocytes

30
Q

Gerbrich antigens with treatment

A

Trypsin: destroyed

Papain: destroys Ge2,4; Ge3 resistant

31
Q

Distinguish anti-Ge2 from anti-Ge3 in absence of rare cells

A

Use papain treated cells

32
Q

Gerbrich antibodies

A

Usually IgG but may be IgM

Usually not clinically significant but anti-Ge3 has caused mild HTR/HDFN

33
Q

Cromer antigen location

A

Decay-accelerating factor (CD55)- a complement regulatory glycoprotein

34
Q

Cromer low incidence antigens

A

Tc^b, Tc^c, and WES^b

Other 15 are high frequency

35
Q

Cromer null

A

Inab phenotype

Make anti-IFC

36
Q

Cromer antigen with cell treatment

A

Destroyed by a-chymotrypsin

Resistant to papain, ficin, and trypsin

Weakened by AET/DTT

37
Q

Cromer antigen is a receptor for what parasite

A

Plasmodium falciparum

38
Q

Cromer antibodies

A

Usually IgG

Not usually considered to be clinically significant

Inhibited by serum or concentrated urine of antigen positive individuals

39
Q

Dombrock gene location

A

Chromosome 12p13

40
Q

Do a/b frequency

Whites

A

Do(a+b-): 18%
Do(a+b+): 49%
Do(a-b+): 33%

41
Q

Do a/b prevalence

African American

A

Do(a+b-): 11%
Do(a+b+): 44%
Do(a-b+): 45%

42
Q

Dombrock null phenotype

A

Gya-

Result of various inactivating mutations

Make anti-Gya

43
Q

Hy- and Jo(a-)

A

Uncommon phenotypes

Negative or weak expression of dombrock antigens

44
Q

Dombrock antigens on treated cells

A

Resistant to papain and ficin

Sensitive to trypsin, a-chymotrypskn, pronase

Sensitive to DTT/AET

45
Q

Dombrock antibodies

A

Typically IgG

Usually weakly reactive

Have been implicated in HTRs but no HDFN

46
Q

Indian antigen location

A

CD44- cell surface receptor for glycosaminoglycan hyaluranan

47
Q

Indian antigen/ prevalence

A

In^a: low
In^b: high

INFA, INJA, INRA: high

48
Q

Indian antigens with RBC treatment

A

Sensitive: papain, ficin, trypsin, a-chymotrypsin. As well as DTT/AET

49
Q

Indian antigen weak expression on

A

Cord cells

In(Lu)

50
Q

Indian antibodies

A

Not generally clinically significant

Anti-Inb has caused HTR

51
Q

Vel blood group

A

1 antigen: Vel- high incidence

52
Q

Vel antigen expression

A

Weak on cord cells

Variable expression among individuals

53
Q

Vel effect on treated RBCs

A

Enhanced by enzymes

Variable effect with DTT/AET

54
Q

Anti-Vel

A

Often a mix of IgM and IgG

Readily activated complement

Cause of severe HTRs though HDFN is rare

55
Q

Diego antigen location

A

Band 3, red cell anion exchanger

56
Q

Diego gene location

A

Chromosome 17q21.31

57
Q

Di^a prevalence

A

Rare in European and African
5% Asian
Up to 50% in n. and s. American indigenous people

58
Q

Di^b prevalence

A

High prevalence in all populations

59
Q

Diego Dia and Dib antibodies

A

Usually IgG reactivity at IAT

May cause HDFN but no known HTRs

60
Q

Wra/Wrb

A

Wra: low
Wrb: high

Expression dependent on GPA presence

61
Q

Anti-Wra

A

Usually IgG
Relatively common

Responsible for severe HDFN and HTRs

62
Q

Diego antigen on treated RBCs

A

Resistant to proteolytic enzymes ficin, trypsin, and papain

Antigens on 3rd extracellular loop sensitive to a-chymotrypsin

63
Q

Chido /Rogers antigen location

A

On fragment of C4d (complement component) that attaches to RBCs from plasma

NOT PRODUCED BY RBCS

64
Q

Chido/Rogers antigen on treated RBCs

A

Destroyed by proteolytic enzymes (papain, ficin)

65
Q

Chido/Rogers antibodies

A

Generally IgG detected at IAT

No known HDFN/HTRs but may cause anaphylactic reactions

Inhibited by plasma of Ch/Rg+ individuals

SBB Review (24 decks)

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