Other Blood Group Systems Flashcards
GPI linked glycoprotein on acetylcholinesterase
Yt
Yt antigens
Yta- high prevalence in all pop.
Ytb- 8% except in israeli’s where it can be up to 26%
No known null phenotype
Yta antigen w/ enzyme or DTT treatment
Destroyed
Yt antibodies
Usually IgG
No HDFN
anti-yta may cause HTR
Yta with trypsin and a-chymotrypsin
Trypsin-not effected
A-chymptrypsin- destroyed
XG blood group antigens
Xga and CD99
XG gene locations
XG : Xp22.32 tip of the short arm- not inactivated by lyonization
CD99 gene is on both X and Y chromosome
Xga prevalence
66% males
89% females
Anti-Xga
Usually IgG reactivity at IAT
Not considered clinically significant
Xga with ficin
Sensitive
Xga with DTT/AET
Resistant
Colton antigens
Co^a, Co^b, Co3, Co4
High prevalence Colton antigens
Co^a, Co3, Co4
Co^b prevalence
10%
Colton antigen location
Aquaporin-1 (red cell water transporter)
Colton gene location
Chromosome 7p14
Colton antibodies
usually IgG
Implicated in HDFN and HTRs
Colton antigen with proteolytic enzymes
Resistant
Anti-Co3
Made by rare Co(a-b-) phenotypes caused by various inactivating mutations
Co4
Required for Co^a expression
Gerbrich high prevalence antigens (6)
Ge2, Ge3, Ge4, GEPL, GEAT, GETI
Gerbrich low prevalence antigens (5)
Wb, Ls^a, An^a, Dh^a, GEIS
Gerbrich antigen locations
GPC and GPD- part of a junctional complex of membrane proteins that interact with protein 4.1 and p55 that help link membrane and it’s skeleton for membrane stability
Gerbrich gene location
Chromosome 2q14-21
GPC receptor for what parasite/virus
Plasmodium falciparum
Influenza A and B
Gerbrich null
Ge:-2,-3,-4
Both GPC and GPD absent
Cells are eliptocytes