Platelet Aggregation Inhibitors

Question 1

clopidogreal trade name

Answer 1

plavix

Question 2

clopidogrel drug classes

Answer 2

platelet aggregation inhibitor, thienopyridine derivative

Question 3

clopidogrel expected effect

Answer 3

inhibit ADP- induced platelet aggregation

Question 4

why use clopidogrel

Answer 4

reduce risk stroke, MI, peripheral arterial disease, TIA, angina, coronary syndrome

Question 5

route admin clopidogrel

Answer 5

PO

Question 6

doses for clopidogrel

Answer 6

coronary syndrome: PO 300mg, then 75mg day with aspirin

recent MI, stroke, TIA, peripheral arterial disease
75mg/ day with/out aspirin

Question 7

clopidogrel adverse effects

Answer 7

every common side effect from meds

Question 8

clopidogrel nursing implications

Answer 8

hepatic studies (AST, ALT, bilirubin, creatine), blood studies (CBC, Hct, cholesterol), anemia, thrombocytopenia, purpura
evaluate: absence stroke MI
teach: blood work, report unusual bruising bleeding
blood work necessary

Question 9

clopidogrel black box warning:

Answer 9

CYP2C19 Allele (poor allele metabolizer)