pituitary disorders Flashcards
disorders caused by
- Disease of the pituitary gland or the hypothalamus
- Trauma
- Tumor
- Vascular lesion
acromegaly
Hypersecretion of growth hormone (GH) that occurs after puberty.
key features of acromegaly
- Enlargement of skeletal extremities, height, shoe size
- Protrusion of jaw
- Headaches, visual problems, blindness
- Muscle weakness
- Organ enlargement: will fall overtime
- more stress of body
acromegaly medications
Octreotide (Sandostatin)-synthetic GH
Parlodel (Permax)- dopamine agonist
thereaputic measures for acromegaly
- Surgical removal of pituitary gland; surgery is generally the first treatment option.
- Replacement therapy will be needed following removal of the pituitary gland and may need needed following radiation therapy
+ Corticosteroids
+Thyroid hormones - Radiation therapy
Dwarfism
Hypersecretion of GH during fetal development or childhood that results in limited growth congenital or result from damage to the pituitary gland
what does dwarfism look like
- Head and extremities are disproportionate to torso
- Face may appear younger
- Short stature, slow or flat growth rate
- Progressive bowed legs and lordosis
- Delayed adolescence or puberty
diagnostic procedure for dwarfism
- Comparison of height/weight against growth charts, slowed growth rate will be noted
- Serum growth hormone level
+Most providers will also evaluate other hormonal levels to ensure that no secondary deficiencies exist
+ MRI of the head (to assess pituitary gland)
deficiency of ADH causes
diabetes insipidus (DI).
- DI is characterized by the excretion of a large quantity of diluted urine.
Excessive secretion of ADH causes
the syndrome of inappropriate antidiuretic hormone (SIADH).
- In SIADH, the kidneys retain water, urine output decreases, and extracellular fluid volume is increased.
Posterior pituitary disorders result in
fluid and electrolyte imbalances.
diabetes insipidus
Caused from a deficiency of ADH
- Reduces the ability of the distal renal tubules in the kidneys to collect and concentrate urine.
DI results in
- Excessive diluted urination: looks like water
- Excessive thirst:dry on inside
- Electrolyte imbalance
- Excessive fluid intake
Risk Factors of Diabetes Insipidus
- Head injury
- Tumor or lesion
- Surgery or irradiation near or around the pituitary gland
- Infection
+ Meningitis
+ Encephalitis - Patients who are taking lithium carbonate or demeclocycline
two main clinical findings
polyuria
polydipsia
DI polyurina
a- brupt onset of excessive urination
- urinary output of 4 to 30 L/day of dilute urine
- failure of the renal tubules to collect and reabsorb water
Di polydipsia
excessive thirst
consumption of 2 to 20 L/day
clinical findings DI
Nocturia: voiding at night
Sunken eyes
Tachycardia
Hypotension
Loss or absence of skin turgor
Dry mucous membranes
Weak, poor peripheral pulses
Weight loss, muscle weakness
Headache, Dizziness, Fatigue
Constipation
Urine chemistry: DI
Think DILUTE.
- Decreased urine specific gravity (less than 1.005)
- Decreased urine osmolality (less than 200 mOsm/L)
- Decreased urine pH
- Decreased urine sodium
- Decreased urine potassium
As urine volume increases, urine osmolality decreases.
DI: serum chemistry
Think CONCENTRATED
- Increased serum osmolality (greater than 300 mOsm/L)
- Increased serum sodium
- Increased serum potassium
- As serum volume decreases, the serum osmolality increases.