adrenal gland Flashcards
what does the adrenal cortext produce
produces glucocorticoids (cortisol), mineralocorticoids (aldosterone) and sex hormones.
drenal medulla produces
catecholamines epinephrine and norepinephrine
addisons disease
Adrenal insufficiency: The hyposecretion of adrenal cortex hormones
addisons caused by
Autoimmune disease
TB histoplasmosis
adrenalectomy
tumors
HIV
Can be induced by the abrupt cessation of steroid medications.
clinical manifestations of addisons
- Weakness and fatigue
- Nausea and vomiting
-Hyperpigmentation - Hypotension
- Increased heart rate
- Hypoglycemia
- Hyponatremia
- Hyperkalemia
- Hypercalcemia
- Nausea and vomiting
- sick all the time
what do you give addison
add cortisol
cushing disease caused
- oversecretion of the hormones the adrenal cortex produces.
- result of a tumor in the pituitary gland resulting in release of the hormone ACTH.
- long‑term use of glucocorticoids to treat other conditions, such as asthma or rheumatoid arthritis.
age for cushings
20-40
causes of increased cortisol in cushings
- Adrenal hyperplasia
- Adrenocortical carcinoma
- Pituitary carcinoma that secretes adrenocorticotropic hormone (ACTH)
- Carcinomas of the lung, gastrointestinal (GI) tract, or pancreas (these tumors can secrete ACTH)
expected findings for cushings
- Weakness, fatigue, sleep disturbances
- Back and joint pain
- Altered emotional state (irritability, depression)
- Decreased libido
physical assessment findings for cushings
- Evidence of decreased immune function and decreased inflammatory response (infections without fever, swelling, drainage, redness)
- Thin, fragile skin
- Bruising and petechiae (fragile blood vessels)
cushings physical assessment
- Hypertension (sodium and water retention)
- Tachycardia
Gastric ulcers due to oversecretion of hydrochloric acid - Weight gain and increased appetite
- Irregular menses
- Dependent edema: Changes in fat distribution, including the characteristic fat distribution of moon face, truncal obesity, and fat collection on the back of the neck (buffalo hump)
cushings what they look like
- Fractures (osteoporosis)
- Bone pain and fractures with an increased risk for falls
- Muscle wasting (particularly in the extremities)
- Impaired glucose tolerance
- Frequent infections, poor wound healing
- Hirsutism
- Acne
- Red cheeks
- Striae (reddened lines on the abdomen, upper arms, thighs)
- Clitoral hypertrophy
- Thinning, balding hair
- Hyperglycemia
- Emotional lability
test for cushing
- dexamethasone supression test: Tests vary in length and amount of dexamethasone to administer.
- 24-hr urine collections show suppression of cortisol excretion in clients who do not have Cushing’s disease.
diagnostic procedures
- X-ray, magnetic resonance imaging, and CT scans identify lesions of the pituitary gland, adrenal gland, lung, GI tract, and pancreas.
- Radiological imaging determines the source of adrenal insufficiency (tumor, adrenal atrophy).