Physiology of Pain Flashcards
Pain is different from all other senses because
the sensation is elicited by multiple stimuli
it preempts all other signals
these differences result in multiple alterations in the physiological functioning of the pain pathways
pain can be characterized as
fast pain
slow pain
fast pain
generally associated with the immediate injury
aka sharp pain
slow pain
often characterized as dull or achy
often occurs after the injury
Pain can be characterized by location
deep pain
muscle pain
visceral pain
somatic/cutaneous pain
again the characteristics of these forms of pain vary due to physiological and anatomical considerations
Sensory receptors
many are bare nerve endings with specialized ion channels that open in response to specific stimuli (i.e. thermoreceptors)
some sensory receptors show quite extensive morphological specilization
Sensing Noxious Stimuli - the nociceptors
Two types of fibers
bare nerve endings can be
A delta fibers
C fibers
A delta fibers
small sparsely myelinated, fast, sharp pain
C fibers
unmyelinated fibers associated with dull pain (slow pain)
Nociceptors must be able to detect
a wide variety of damaging stimuli
Types of Nociceptors
sensitive to both thermal and mechanical stimuli (most)
sensitive to only thermal
sensitive to only mechanical
silent/sleepin
Many mixed modality nociceptors also express a
mechanosensitibe Na channel (SCN9A or Na1.7)
Mutations in the nocicieptive Na channels lead to
an absence of pain sensation
paroxysmal pain syndrome
Mutations in the nocicieptive Na channels lead to
an absence of pain sensation
paroxysmal pain syndrome
Unlike other receptors, nociceptors express _________ which alter the sensitivity of the nociceptors to input
number of ligand gated receptors (in addition to the stimulus gated channels)