Memory Flashcards
learning
acquisition of new information (facts)
Memory
retention of new information
learning and memory enable us to modify our behavior based on
new information and to extrapolate to unfamiliar situations
Procedural memory
implicit memory
non-declarative
reflexive memory
skills and habits that have been used so much they are automatic
procedural memory - anatomic substrates
cerebellum - motor skills
nucleus accumbens - non motor
Declarative memroy
explicit memory
the conscious recognition/ recollection of learned facts and experiences
subdivided into two forms
two forms of declarative memory
episodic - memory of events
semantic - memory of words, language, and rules
Declarative and procedural memory are coded for using
distinct anatomical stubstrates -
the physiology is not very different
Can also classify memory based on duration
short term
long term
working
the neural mechanism for each of these is DIFFERENT
short term memory
sec -hrs
Long term memory
years
WOrking memory
recalling a fact/memory for use - it may be a subset of short term memory
Working memory, ie
recalling a fact for use in a test question
you’ve learned it, now are retrieving it for use
will look very much like short term memory
declarative memory ie
the fact you learned for the test
this is events or facts stored in your memory
procedural memory i.e.
bike riding
motor skills that are used so much that you memorize the motor sequence required to produce the action
short term memory i.e.
the fact that you crammed in 5 minutes before the test began
long term memory i.e.
the memories of your life so far
involve changes in synapses, new synapses, etc
The production of memory and learning requires the induction of
neuronal and synaptic plasticity
Plasticity
alterations in the CNS based on use
may be synaptic function that;s altered
may be changes in the physical structure of the neurons (more synapses, new branches to new cells)
Plasticity - 2 categories
changes in synaptic function
Changes in the structure of neurons
plasticity - changes in synaptic functioning (3)
post - tetanic potentiation
pre-synaptic facilitation
Long term potentiation (LTP)
plasticity - changes in the structure of the neurons (3)
Gain/loss of synapses
structural changes in dendrites
structural changes in the soma of the neuron
Post tetanic stimulation - conditions
breif, high frequency discharge of presynaptic neuron
produces increased NT release
lasts about 60 seconds
Post tetanic stimulation - Mechanism
the high level of stimulation allowed more Ca to enter the terminal than could be death with (faster than the Ca exchange pump can pump the Ca out)
With more Ca, mor vesicles fuse, leading to greater NT release
post tetanic stimulation duration
SHORT lasting, only lasts as long as it take the pump to get the CA out.
but sets the stage for other things.
post tetanic stimulation duration
SHORT lasting, only lasts as long as it take the pump to get the CA out.
but sets the stage for other things.
Pre synaptic facilitation
start with a “normal” chemical synapse–>add another neuron that synapses on the presynaptic terminal of neuron A–>when activated, this terminal releases Serotonin,–> binding of the 5HT leads to activation of adenylyl cyclase and increased cAMP–> K channels in Neuron A become phophoyrlated and opening is delayed = depolarization is delayed
because the AP sticks around longer, we see greater NT release
LTP - definition
a series of changed in the pre and post synaptic neurons of a synapse which leads to increased response to the released NT
must last for HOURS after the stimulation
usually follows strong stimulation
NT can be EAA