Neurotransmitter Systems Flashcards

0
Q

Ach - General function

A

Crucial in producing consciousness, but not awareness
control of voluntary motion
initiation of REM sleep

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1
Q

Ach - central locations

A

pons
midbrain
the striatum

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2
Q

Ach - vesicular storage

A

Ach stored in clear vesicles

Moved into vesicles by VAchT

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3
Q

Ach - Catabolism

A

Acetylcholinesterase bound to the POST synaptic cell membrane

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4
Q

Ach Receptors (2)

A

nicotinic (NAchR)

muscarinic (MAchR)

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5
Q

Muscarinic receptor properties

A

4 or 5 different types, all activated by muscarine
serpentine receptor
GPCR

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6
Q

M1 (neuronal) MAchR

A

Gq

increase IP3/DAG, Increase Ca++

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7
Q

M2 (cardiac) MAchR

A

Gi

decrease cAMP, increase K+ efflux

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8
Q

M3 (sm m. of bronchi, vasculature, endothelial cells of vasculature) MAchR

A

NO
Gq
IP3/DAG, increase Ca++

in the vasculature NO is the major effector (which wins)

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9
Q

Nicotinic receptors

A

located at NMJ (Na), autonomic ganglia, other parts of the CNS (Ca, Na)
5 subunits
IONOTROPIC
allow for Na entrance, allthough some neuronal forms allow for significant Ca influx

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10
Q

Amino acid NTs (list)

A

glutamate, aspartate, taurine (EAAS)

GABA, glycine (inhibitory amino acids)

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11
Q

GABA - location

A

cerebellum
cortex
retina

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12
Q

GABA - functional roles

A

major inhibitory NT in the higher CNS
critical for producing consciousness/awareness
control of voluntary motion

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13
Q

GABA - synthesis

A
glutamate decarboxylase (GAD)
derived from glutamate
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14
Q

GABA - how is action limited

A

reuptake

catabolism by GABA transaminase

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15
Q

GABA - what does it bind to

A

GABA-A and GABA-B receptors

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16
Q
GABA-A receptors
ionotropic/metabotropic
subunits
ion conductance (if ionotropic)/Gprotein if metabotropic
other important chemicals
A

IONOTROPIC
5 subunits
Cl- conductance
benzodiazapine site potentiates

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17
Q
GABA-B receptors
ionotropic/metabotropic
subunits
ion conductance (if ionotropic)/Gprotein if metabotropic
other important chemicals
A

heterodimer G protein (Gq and Gi) decreases adenylyl cyclase, increases K+ efflux. AND decreases IP3/DAG, decreases Ca influx
-

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18
Q

Many general anesthetics are now postulated to produce anesthesia by activating what receptors?

A

GABA receptors, mostly GABA-A, at extra-synaptic locations throughout the cortex

19
Q

Glycine - location

A

spinal cord
brainstem
forebrain (less than gaba)

20
Q

glycine - function

A

mediates many spinal inhibitions

21
Q

glycine - binds to

A

glycine receptors

22
Q
glycine receptor
ionotropic/metabotropic
subunits
ion conductance (if ionotropic)/Gprotein if metabotropic
other important chemicals
A

ionotropic
a=glycine binding, b = structural
Cl-
blocked by strychnine

23
Q

Peptide NT (2)

A

opiods
endocannabanoids

coded for by genes, originally thought to be neuromodulators

24
Q

Opiods - location

A

basal ganglia
hypothalamus
parabrachial nuclei and raphe nuclei

25
Q

opiods - general functions

A

modification of nociceptive inputs

modification of mood/affect

26
Q

Opioid - 4 precursor molecules

A

proenkephalin
pro-opiomelanocortin
prodynorphin
orphanin FQ

27
Q

proenkephalin - sequence and 2 major variants

A

tyr-gly-gly-phe-x

met-enkephalin
leu-enkephalin

28
Q

pro-opiomelanocortin (POMC)

A

B endorphins

29
Q

prodynorphin

A

When you cut up prodynophin, it gives rise to 4 opioid molecules

3 molecules of leu-enkephalin
dynorphins (8aa or 17aa) –> a smaller form OR the larger form

30
Q

Orphanin FQ aka?

A

nociceptin

31
Q

How are opioids made?

A

Since they are peptides, they are made through the usual protein synthetic machinery

32
Q

How do we limit opioid action?

A

enzymatic activity, possibly after reuptake
enkephalinase A and B
aminopeptidase

33
Q

What (3) receptors do opioids bind to?

A

mu, kappa, delta

34
Q

Mu receptor

receptor type and effects

A

serpentine
ANALGESIA, RESPIRATORY DEPRESSION, EUPHORIA
sedation, constipation

35
Q

Kappa receptor

receptor type and effects

A

serpentine receptor,
ANALGESIA, DYSPHORIA
diuresis, miosis

36
Q

Delta receptor

receptor type and effects

A

serpentine

ANALGESIA

37
Q

all opioid receptors are _______ and are ______ adenylyl cyclase

A

serpentine receptors
inhibit
Mu - increases K+ efflux and hyperpolarizes
Kappa and delta - decrease Ca

38
Q

The two endocannabanoids are

A

anadaminde

2-AG (arachydonylglycerol)

39
Q

Anadamide

A

“bliss”

arachidonic acid +ethanoloamine

40
Q

2-Arachydonylglycerol

A

arachadonic acid esterified into the middle, #2 position of glycerol

41
Q

Distribution of endocannabinoids in the CNS

A
broad distribution
hippocampus - memory formation
Basal Ganglia - affect, motor
spinal cord - modulation of nociception
neocortex - neuroprotective (?)
42
Q

What type of receptors do the endocannabinoids bind to? (2)

A

CB-1 and CB-2

43
Q
CB-1 receptor 
where
what type
what it does
what it binds
A

axons and presynaptic terminals of EAA and GABA synapses
Gi protein coupled receptor
reduces NT release
binds to either anadamide or 2-AG equally

44
Q
CB -2 receptor
where
what type of receptor
additional sites found
function
A

found in brain MICROGLIA, not neurons
metabotropic
immune system and gut
antiinflammatory, in brain cause macrophage to remove B-amyloid