Photodynamic Therapy

Question 1

Light activation leads to vascular collapse and ischaemic tumour necrosis

Answer 1

True

Question 2

Absorbed ALA induces porphyrinogenesis, thereby inducing “porphyrin” at the cellular level

Answer 2

True

Question 3

PpIX, blue light activation will provide a deeper clinical effect compared to red light

Answer 3

False - red light deeper clinical effect

Question 4

At very high irradiances of the activating light , there is significant heat production due to both non radiative photosensitiser absorption/relaxation and nonspecific light absorption by other tissue chromophores

Answer 4

True

Question 5

AK PDT clearance rate is comparable to 5-FU, imiquimod and ingenol mebutate

Answer 5

T

Question 6

On acral sites, PDT may perform better than LN2 for treatment of AK’s

Answer 6

False - vice versa

Question 7

Mycosis fungoides cannot be treated with PDT

Answer 7

False - effective for patch/plaque but tumour-stage less responsive

Question 8

List non-oncologic PDT applications

Answer 8

Acne
Photoageing
Psoriasis
Cutaneous infections
Vascular anomalies
Hypertrophic scars and keloids

Question 9

Following PDT, complete avoidance of all light is necessary

Answer 9

False - regular indoor light exposure provides a safe means by which low level photo-bleaching can hasten clearance of residual photo active agents from skin

Question 10

Pain associated with PDT occurs within seconds to minutes of illumination of skin with artificial light

Answer 10

True

Question 11

Rate of light delivery does not influence the degree of pain

Answer 11

False -= lower irradiances are more tolerable

Question 12

At end of tx, treated site usually exhibit immediate wheal and flare reaction

Answer 12

True

Question 13

PDT associated with transient memory impairment

Answer 13

True

Question 14

PDT associated with alopecia

Answer 14

True

Question 15

PDT associatd with Pityriasis rubra pilaris

Answer 15

True