Histiocytoses Flashcards
Langerhans cells are antigen presenting cells in the epidermis, bronchi and mucosa
True
Skin biopsy of LCH demonstrates an inflammatory infiltrate of eosinphils, histiocytes and lymphocytes
True
Stains of LCH demonstrate positivity to CD1a,CD117
False = not CD117, which is for mast cells, but CD207 +
Hand-Schuller-Christian is self healing
False. This is Hashimoto-Pritzker .
- Hand Schuller Christian has exophthalmos, diabetes insipidus and lytic bone lesions and is low-risk multisystem LCH
Benign cephalic histiocytosis occurs in infants >1 year of age most commonly
False - <1year of age
Benign cephalic histiocytosis mostly occurs by age 1 and always within the first 3 years
T
What are the 3 histologic patterns for benign cephalic histiocytosis
PDL
- papillary dermal
- diffuse
- lichenoid
Generalised eruptive histiocytoma affects adults more than children
True
Treatment is generally required for generalised eruptive histiocytoma
False - generally NOT required
Indeterminate cell histiocytosis is positive for s100 and CD1a which are LCH markers, and non LCH markers CD68+ and CD163+
True
Indeterminate cell histiocytosis has two variants : solitary and generalised
True
Indeterminate cell histiocytosis is Langerin positive (CD207)
False - Langerin negative
Touton giant cells present in indeterminate cell histiocytosis
True
Juvenile xanthogranuloma is the most common histiocytosis
True
JXG associated with hyperlipidaemia
False - reason for progressive lipidation of histiocytes in absence of hyperlipidaemia is unclear