BOLOGNA CH107 Malignant Skin Tumours Flashcards
Which gene is mutated in patients with basal cell naevus syndrome
PTCH1
Features of Gorlin Syndrome
Palmar pits, calcification of falx cerebri, bifid ribs,
Odontogenic keratolysis, macrocephaly, medulloblastoma, ovarian fibromas, cardiac fibromas, bridging of sella turcica, sprengel deformity
Intermittent, recreational sun exposure is a less important risk factor than cumulative UV radiation in development of BCC
F, other way around
BCC appears to have the capacity for infinite growth
T
BCC can spontaneously regress
F = this is not a feature of BCC
BCC devoid of stroma failed to proliferate and differentiated into keratin filled cysts in an experiment
T
Cumulative UV radiation received over time is a significant risk factor is a significant risk factor for SCC
T
There is a strong correlation between tumour thickness and metastases of SCC
T
Alterations in TP53 gene are the most common genetic abnormalities found in actinic keratoses, SCC in situ , invasive SCC
T
keratoacanthomas of Muir Torre Syndrome are more genetically stable than sporadic KA’s
False, other way around
Ferguson Smith Syndrome is autosomal recessive, due to mutations in TGFBR1 gene
F, autosomal dominant
Increased risk of SCC but not BCC for those exposed to artificial UV sources
F, both
Naevus sebaceous predisposes to BCC but not SCC
Table 108.2
False, both
Porokeratosis , particularly linear, predisposes to SCC but not BCC
T
Specific HPV subtypes act as co-carcinogens in conjunction with UVR in the early development of SCC
T
List risk factors for skin cancer in transplant recipients
Skin photo types I/II
Cumulative sun exposure
Age at transplantation
Degree and length of immunosuppression
Transplant recipients are prone to developing numerous lesion and more likely to suffer local/regional recurrences and metastases
T
Which HPV strains can be seen in tumours from transplant recipients?
Those that occur in benign warts (HPV1, 2)
EV (HPV-5 and others)
High risk oncogenic warts (HPV types 16, 18)
Low risk oncogenic genital warts (HPV 6, 11)
Patients who receive haematopoietic transplants experience the same increase in skin cancer as solid organ
F, due to shorter duration of immunosuppression hypothesised
What is verrucous carcinoma
Rare, well differentiated variant of SCC occurring in middle aged and older adults
Subtypes of verrucous carcinoma
- Epithelioma Cuniculatum (plantar surface of the foot)
- Giant condyloma acuminata of genitalia (Buschke-Lowenstein tumour)
- Oral florid papillomatosis (oral mucosa)
Distinguishing between large wart or condyloma acuminatum can be difficult
T
Verrucous carcinoma often metastasises
F , do not usually metastasise but often recur after attempted removal
