Bologna UV light therapy

Question 1

GUTTATE and Seborrheic (minimally elevated) forms of psoriasis respond least favourably to BB-UVB

Answer 1

False - most favourably, whilst chronic plaque type psoriasis is more resistant to BB-UVB

Question 2

If patient has persistent asymptomatic erythema, there is no dose increase

Answer 2

True - stays the same

Question 3

If pt has painful erythema with or without oedema or blistering, treatment is withheld until symptoms subside

Answer 3

True

Question 4

For patients with minimal erythema, treatment is held at the same dose until erythema subsides

Answer 4

False - increase by up to 20% (15% if treatments are given five times per week or daily)

Question 5

Mycosis fungoides phototherapy response relates to the type (eg. Patch vs. plaque stage) but NOT the extent of skin involvement

Answer 5

True

Question 6

Follicular repigmentation in vitiligo is more favourable than marginal repigmentation

Answer 6

True

Question 7

in PMLE - 2-3 treatments per week for total of 15 sessions are typically administered prior to anticipated increased exposure to sunlight

Answer 7

True

Question 8

NBUVB found to be effective for severe seborrhoeic dermatitis

Answer 8

True

Question 9

Psoralens are naturally occurring furocoumarins

Answer 9

True

Question 10

PUVA is far more effective in inducing apoptosis in keratinocytes than in lymphocytes

Answer 10

False - other way around

Question 11

Topical 8-MOP is 0.1-0.01% in cream, ointment or lotion bases

Answer 11

True

Question 12

Atopic dermatitis is more difficult to treat than psoriasis with PUVA

Answer 12

True

Question 13

PUVA causes permanent involution of cutaneous mastocytosis

Answer 13

False - temporary

Question 14

Treatment of cutaneous mastocytosis with PUVA leads to loss of Darier sign, relief of itching, and flattening and sometimes disappearance of cutaneous macules and papules

Answer 14

True

Question 15

In the use of PUVA for cutaneous mastocytosis, systemic symptoms such as histamine induced migraines and flushing do not fade

Answer 15

False - they do fade with continuous treatment

Question 16

UVA can induce cataracts by forming psoralen-protein photoproducts

Answer 16

True

Question 17

PUVA induces profuse dark stellate lentigines

Answer 17

True

Question 18

No incr risk of melanoma has been found associated with PUVA lentigines

Answer 18

True

Question 19

Explain how extracorporeal photophoresis is performed (ECP)

Answer 19

Involves the passage of blood from an arm vein through a photophoresis machine and then back to the patient. Within the machine, flow separator harvests peripheral blood mononuclear cells . The red cell fraction is returned back to the patient . The collection of PBMC is exposed to 2J/cm2 of UVA and reinfused into the patient. The treatment is repeated on two successive days with 2-4wk intervals.

Question 20

Side effects of ECP?

Answer 20

• hypotension

- vasovagal reflex due to volume shifts in treatments