Bologna CH111 Adnexal Neoplasms Flashcards
Hair follicle naevi are hamartomas in which hairs and follicles that ensheath them have abnormal morphology or size or are present in increased numbers
T
Hamartomas are benign proliferation’s composed of cellular elements native to a site, in aberrant proportion
T
Accessory tragus overlaps with hair follicle naevus (two entities may be the same)
T
Child grows proportionally with hair follicle naevus
F , child grows disproportionally faster than the lesion
Trichofolliculoma presents as a papule or nodule involving the face, scalp or upper trunk
T
How does Pilar sheath acanthoma differ from trichofolliculoma?
Pilar sheath acanthoma similarly has a central infundibulum with follicle structures radiating from the centre, however they do not recapitulate the full hair follicle - only follicular isthmus and outer sheath (unlike trichofolliculoma)_
Disorders with angiofibromas
TS
Birt-Hogg-Dube
MEN1
Fibrofolliculoma displays slender strands of follicular mantle cells emanating from a folliculosebaceous unit at the level of the isthmus
T
Naevus sebaceous - list secondary neoplasms
TTDSAP Trichoblastoma (most common) Trichilemmoma Desmoplastic trichoepithelioma Sebaceous adenoma Apocrine adenoma Poroma
- malignancy probably develops only in longstanding or neglected lesions but exceptionally can be a source of mortality
Pathology of chondroid syringoma
- prominent collagen component to stroma, but myxoid and lipocytic zones can also be found
—> large inter-anastomosing and branching tubules lined by two cell layers - columnar cells with decapitation secretion at the luminal border and cuboidal cells peripherally (this configuration has been dubbed apocrine mixed tumour)
Disorders with pilomatricoma
Rubenstein turns wool in my garden
- Rubenstein syndrome
- Turner Syndrome
- edWard syndrome
- Myotonic dystrophy
- Gardner’s syndrome
Retention of PTEN expression with trichilemmoma , assessed with IHC, is suggestive of Cowden syndrome
F, loss of PTEN expression
There is increased incidence of syringomas in Asian population
T
Poromas can occur following chemotherapy or radiation therapy
T
Palms and soles demonstrating sessile vascular plaques with a thin indented moat is suggestive of which tumour
Poromas
