Infections - Viral Flashcards
Generalised palpable lymphadenopathy is present with CD4+ cell counts of >500/mm3 (ie. stage I HIV)
True `
Primary HIV exanthem is also known as the acute retroviral syndrome
True
HIV infected women have a 3 x increased risk of CIN
True
HIV parasite associations
Leishmanisis
Strongyloides
Acanthamebiasis
Scabies
Leishmanisis in HIV has a higher rate of therapeutic failure
True
HIV induces a shift from a protective Th1 to a Th-type reaction pattern in leishmanisis
True
List HIV related dermatoses that are not infectious in nature
Seb derm Psoriasis Reactive arthritis Xerosis PRP type VII Pruritic papules eruption of HIV Eosinphilic folliculitis HIV associated
Hair and nail disorders secondary to HIV include TRICHOMEGALY due to prolonged anagen resulting from IFNa and zidovudine
True
Nail changes are uncommon in HIV patients
False common in 2/3
HIV Pt have same risk of developing merkel cell ca and sebaceous ca
False, elevated
IRIS occurs 1wk to 3 mo after ART with higher risk in those with high CD4+ T cell counts perior to therapy
False in low CD4+ T cell counts <50/mm3
Condyloma lata are moist flat papules/plaques with macerated eroded surfaces in intertriginous areas
True
HSV is often acquired asymptomatic ally
T
Grouped blisters on buttocks almost always HSV1
False HSV2
Complications of genital herpes
Neuropathic bladder Enhanced HIV transmission due to ulcer Psychosocial morbidity Neonatal herpes Aseptic meningitis
First ep of HSV needs Valtrex 500mg BD for 5-10 days or acyclovir 400mg TDS for 5-10days
True
How to perform a Tzanck smear
Deroof blister with blunt edge of scalpel blade,
Scrape base of lesion
Smear tissue on clean microscope thinly
Allow to dry, fix specimen with preservative (either alcohol or heat)
Chance of baby being infected with HSV in setting of genital herpes
Very very low, in setting of recurrent infection <3% due protective transplacental antibody. If primary genital herpes, risk is 25-50% for vaginal delivery . Might need acyclovir closer to pregnancy or opt for C section
HPV strains that cause anogenital warts are which subtypes?
- HPV 6 and 11
HPV 16 and 18 mainly responsible for epidermodysplasia verruciformis
False, this is HPV 5 and 8
HPV 16 and 18 largely cause genital and cervical dysplasia and carcinoma
True
What strain of HPV causes plantar wart
HPV1
What strain of HPV causes verruca vulgaris
HPV2
What strains of HPV cause verruca plans
3 and 10
