Pharmacology of the Eye

Question 1

The most anterior portion of the uvea is the

Answer 1

Iris

Question 2

Contains muscles that regulate the diameter of the pupil

Answer 2

Iris

Question 3

What are two muscarinic receptor antagonists?

Answer 3

Atropine and Scopolamine

Question 4

The prototype tertiary amine found in atropa belladonna

Answer 4

Atropine

Question 5

Closely related to atropine

-Formulated as a transdermal patch for motion sickness

Answer 5

Scopolamine

Question 6

Atropine and scopolamine are both well absorbed from the

Answer 6

Gut and conjunctiva

Question 7

Has the pharmacological effects of dry as a bone, blind as a bat, mad as a hatter, hot as hell, red as a beet, and full as a flask

Answer 7

Atropine and scopolamine

Question 8

A tertiary amine with a much shorter duration than atropine

Answer 8

Tropicamide

Question 9

Atropine’s long half-life in the eye is useful for therapy of

Answer 9

Amblyopia

Question 10

In addition to controlling lens shape, the Ciliary body produces

Answer 10

Aqueous humor

Question 11

Aqueous humor secreted by the epithelium of the ciliary body flows through the anterior chamber and exits via the

Answer 11

Canal of Schlemm

Question 12

Secretion of aqueous humor is controlled by

Answer 12

B-receptors

Question 13

Contraction of the ciliary muscle, under muscarinic receptor control, puts tension on the trabecular network to facilitate

Answer 13

Outflow

Question 14

Characterized by increased pressure in the anterior chamber

Answer 14

Glaucoma

Question 15

Glaucoma is usually attributed to partially obstructed

Answer 15

Aqueous humor outflow

Question 16

The treatment goal for glaucoma is to reduce IOP to prevent progressive

Answer 16

Glaucomatous optic nerve damage

Question 17

Reduce production of AH to lower IOP

Answer 17

Beta-Blockers

Question 18

Facilitate outflow of AH to reduce IOP

Answer 18

Muscarinic agonists or cholinesterase inhibitors

Question 19

Lacrimal drainage goes to the

Answer 19

Nose

Question 20

Lacrimal drainage goes to the nose, lined by

Answer 20

Highly mucosal epithelium

Question 21

Drugs applied to the eye may have access to systemic circulation via

Answer 21

Nasal absorption