Pharmacogenomics COPY Flashcards
Do not use abacavir if the pt has + what?
A. KRAS B. 2C19*2 or *3 C. HLA-B5701+ D. HLA-B5801+ E. 2D6
do NOT use abacavir if the pt is HLA-B5701+
do Not use allopurinol if the patient has + what?
A. KRAS B. 2C19*2 or *3 C. HLA-B5701+ D. HLA-B5801+ E. 2D6
do NOT use allopurinol if the pt is HLA-B5801+
If the patient is HLA-B1502 positive what 3 medications do you NOT use?
A. Warfarin B. Trastuzumab C. Flurouracil D. Cetuximab E. Emtasine F. Azathioprine G. Carbamazepine H. Pertuzumab I. Phenytoin J. Fosphenytoin
carbamazepine, phenytoin, fosphenytoin
G, I, J
consider a different therapy instead of clopidogrel if the patient has?
A. KRAS B. 2C19*2 or *3 C. HLA-B5701+ D. HLA-B5801+ E. 2D6
consider a different therapy instead of clopidogrel if the patient has 2C19 *2 or *3
If the patient is ultra fast or a poor metaboliizer of this, do NOT use codeine
A. KRAS B. 2C19*2 or *3 C. HLA-B5701+ D. HLA-B5801+ E. 2D6
If the patient is ultra fast or a poor metaboliizer 2D6 do NOT use codeine
If 2C9*2 and *3, or VKORC1 start this medication at a lower dose.
A. Warfarin B. Trastuzumab C. Flurouracil D. Cetuximab E. Emtasine F. Azathioprine G. Carbamazepine H. Pertuzumab I. Phenytoin J. Fosphenytoin
Warfarin
A.
If the tumor is HER2 negative do NOT use these 2 medications.
A. Warfarin B. Trastuzumab C. Flurouracil D. Cetuximab E. Capecitabine F. Azathioprine G. Carbamazepine H. Pertuzumab I. Phenytoin J. Fosphenytoin
Trastuzumab emtansine, pertuzumab –> If HER2 negative do NOT use
B, H
do NOT use this drug if the patient is KRAS positive?
A. Warfarin B. Trastuzumab C. Flurouracil D. Cetuximab E. Capecitabine F. Azathioprine G. Carbamazepine H. Pertuzumab I. Phenytoin J. Fosphenytoin
Cetuximab –> KRAS, if positive do NOT use
If the patient has low TPMT (thiopurine methyltransferase) activity, start this medication at a low dose or use an alternative.
A. Warfarin B. Trastuzumab C. Flurouracil D. Cetuximab E. Capecitabine F. Azathioprine G. Carbamazepine H. Pertuzumab I. Phenytoin J. Fosphenytoin
Azathioprine
If the patient is deficient id DPD (dihydropyrimidine dehydrogenase) what 2 medications should you NOT use?
A. Warfarin B. Trastuzumab C. Flurouracil D. Cetuximab E. Capecitabine F. Azathioprine G. Carbamazepine H. Pertuzumab I. Phenytoin J. Fosphenytoin
Capecitabine, fluorouracil do NOT use if the patient is deficient in DPD
E, C,
