Pharmacogenomics

Question 1

do not use abacavir if the pt has + what?

Answer 1

do NOT use abacavir if the pt is HLA-B5701+

Question 2

do Not use allopurinol if the patient has + what?

Answer 2

do NOT use allopurinol if the pt is HLA-B5801+

Question 3

If the patient is HLA-B1502 positive what 3 medications do you NOT use?

Answer 3

carbamazepine, phenytoin, fosphenytoin

Question 4

consider a different therapy instead of clopidogrel if the patient has?

Answer 4

consider a different therapy instead of clopidogrel if the patient has 2C19 *2 or *3

Question 5

If the patient is ultra fast or a poor metaboliizer of this, do NOT use codeine

Answer 5

If the patient is ultra fast or a poor metaboliizer 2D6 do NOT use codeine

Question 6

If 2C9*2 and *3, or VKORC1 start this medication at a lower dose.

Answer 6

Warfarin

Question 7

If the tumor is HER2 negative do NOT use these 2 medications.

Answer 7

Trastuzumab emtansine, pertuzumab –> If HER2 negative do NOT use

Question 8

do NOT use this drug if the patient is KRAS positive?

Answer 8

Cetuximab –> KRAS, if positive do NOT use

Question 9

If the patient has low TPMT (thiopurine methyltransferase) activity, start this medication at a low dose or use an alternative.

Answer 9

Azathioprine

Question 10

If the patient is deficient id DPD (dihydropyrimidine dehydrogenase) what 2 medications should you NOT use?

Answer 10

Capecitabine, fluorouracil do NOT use if the patient is deficient in DPD