Naplex things to know Flashcards
What is the acronym for Major Inducers?
PS PORCS
Phenytoin Smoking Phenobarbital Oxcarbazepine Rifampin Carbamazepine St. John's Wort
What do Major inducers do to drug levels?
Major inducers decrease drug levels
PS PORCS Phenytoin Smoking Phenobarbital Oxcarbazepine Rifampin Carbamazepine St. John's Wort
What are the major inducers (7)?
PS PORCS
Phenytoin Smoking Phenobarbital Oxcarbazepine Rifampin Carbamazepine St. John's Wort
What is the acronym for Major Inhibitors?
G-PACMAN
Grapefruit Protease Inhibitors (ritonavir) Azoles C- Cyclosporin, Cimetidine, cobistat Macrolides - BUT not azithromycin Amiodarone Non-DHP CCB (diltiazem and verapamil)
What do Major Inhibitors do to drug levels?
Major inhibitors increase levels – Then INHIBIT the metabolism to elimination.
G-PACMAN Grapefruit Protease Inhibitors (ritonavir) Azoles C- Cyclosporin, Cimetidine, cobistat Macrolides - BUT not azithromycin Amiodarone Non-DHP CCB (diltiazem and verapamil)
What are the major Inhibitors? (7-11)
G-PACMAN
Grapefruit Protease Inhibitors (ritonavir) Azoles C- Cyclosporin, Cimetidine, cobistat Macrolides - BUT not azithromycin Amiodarone Non-DHP CCB (diltiazem and verapamil)
What is the preferred nasal steroid in pregnancy?
budesonide (Rhinocort) is the preferred nasal steroid in pregnancy
What are the preferred oral antihistamines in pregnancy?
Zyrtec and Claritin are the preferred oral antihistamines in pregnancy
Intranasal ipratropium bromide (Atrovent) is only good for decreasing rhinorrhea caused by?
Intranasal ipratropium bromide (Atrovent) is only good for decreasing rhinorrhea caused by nasal dryness
Which Intranasal must be used scheduled, not PRN?
Intranasal cromolyn (Nasalcrom) must be used scheduled, NOT PRN
What age group should you NOT use ceftriaxone in?
do NOT use ceftriaxone in neonates (<28days)
What should you use as malaria prophylaxis for preggos and children?
Chloroquine or mefloquine (Lariam) dosed WEEKLY
What is something that can decrease the absorption of allopurinol (Zyloprim)?
Antacids decrease allopurinol absorption
What is first line in CKD?
Phos binders –> calcium based (Tums, PhosLo) is first line due to price
What is the generic name of Renvela? What is it used for?
Sevelamer (Renvela) –> used for CKD, is non-calcium, non-aluminum, not systemically absorbed. Also lowers total cholesterol and LDL ~15-30%
In addition to CKD what does Sevelamer (Renvela) also do?
Sevelamer (Renvela) also lowers total cholesterol and LDL ~15-30%
When is erythropoietin (ESA) used in CKD?
ESA is only used when hemoglobin is <10 and discontinued if > 11
What forms of Hepatits are vaccines available for?
vaccines are available for Hep A and Hep B
What is fist line OTC for headache/pain in cirrhosis pts?
Tylenol is first line OTC for headache/pain in cirrhosis pts. it is safer than NSAIDS due to risk of GI bleed, blunting and diurectic response, and exacerbating renal dysfunction.
What vaccinations do you need if you have Asplenia?
- H. influenza type B
- Pneumococcal
- Meningococcal
What is the MOA of triptans?
5-HT1 agonist and cause vasoconstriction of cranial blood vessels
What is the starting dose for Viagra, Revatio?
Sildenafil (Viagra, Revatio) - starting dose is 50mg
What is the starting dose for Cialis, Adcirca?
tadalafil (Cialis, Adcirca) - start dose is 10mg
What is the starting dose for Levitra, Staxyn ODT?
Vardenafil (Levitra, Staxyn ODT) - start dose is 10mg
What is the Start dose for Stendra?
Avanafil (Stendra) - start dose is 100mg
Use 50mg if pt >65 years, using a 3A4 inhibitor, using an alpha blocker, severe renal/liver impairment.
What is the generic of Kapvay?
Clonidine ER (Kapvay) this brand is used for ADHA
What is the generic of Intuniv?
guanfacine ER (Intuniv) used for ADHA
What are the main SE’s of Kapvay and Intuniva?
Clondidine ER (Kapvay) and guanfacine ER (Intuniv) are sedating and lower blood pressure.
What is the generic of Focalin?
Dexmethylphenidate
What is the generic of Concerta?
Methylphenidate (Concerta, Ritalin, Quillivant)
what is the generic of Ritalin
Methylphenidate (Concerta, Ritalin, Quillivant)
what is the generic of Quillivant
Methylphenidate (Concerta, Ritalin, Quillivant)
Which BZDs are preferred in elderly because they are metabolized to inactive compounds (glucuronides)
LOT (Lorazepam, oxazepam, temazepam)
What is Temazepam (Restoril) indicated for?
Temazepam (Restoril) is longer acting and NOT indicated for anxiety. It is used for sleep.
What is the main medication used for Alzheimer’s?
Aricept (Donepezil)
What medication is added to Donepezil in moderate to severe Alzheimer disease. What is the combonation called?
Memantine (Namenda), the combo pill is Namzaric
When do you take Donepezil (Aricept)?
take at night due to nausea. “sleep through” the nausea so during the day the nausea is not so bad. Other side effects include: insomnia, bradycardia, tremors.
What does the term comminution mean?
comminution means to reduce solids from an average particle size to a smaller average particle size.
Magnesium stearate is an example of a?
magnesium stearate is an example of glidant/lubricant = improves flowability of powder.
Sodium lauryl sulfate is and example of a?
sodium lauryl sulfate is and example of a Surfactant = neutralizes static charge and keeps powder from floating away.
Magnesium oxide, magnesium carbonate and kaolin are examples of ?
Magnesium oxide, magnesium carbonate and kaolin are examples of adsorbent = keeps powder dry
What does the term eutectic mean?
eutectic = two components, when mixed, will melt at a lower temperature than either individual melting point.
What 2 things are used as plasticizers - used to make capsules less brittle/more flexible?
glycerol, sorbitol
Between lotion, cream, ointment, which one contains the most water?
Lotion contains the most water.
Between lotion, cream, ointment, which one contains the most oil?
Ointment contains the most oil.
What is Pluronic lecithin organogel (PLO) used for?
Pluronic lecithin organogel (PLO) is used for transdermal drug delivery - gel = semisolid impenetrable by liquid.
What is an emulsion?
emulsion = liquid dispersed in liquid.
What is an emulsifier?
emulsifier = Surfactant that reduces surface tension between oil and water.
What is an suspension?
Suspension is a solid dispersed in liquid
What are wetting agent/levigating agent?
Wetting agent/levigating agent - Surfactant that helps incorporate insoluble drug into liquid.
Low HLB < 10 (lipophilic) are more ____ soluble and used for ______ emulsions
Low HLB < 10 (lipophilic) are more oil soluble and used for water-in-oil (w/o) emulsions
Low HLB > 10 (hydrophilic) are more _____ soluble and used for _____ emulsions
Low HLB > 10 (hydrophilic) are more water soluble and used for oil-in-water (o/w) emulsions
What is the BUD for non-aqueos formulations
The BUD for non-aqueous formulations = any API or 6 months
What is the BUD for water containing oral formulations in the fridge?
14 days in the fridge
What is the BUD for water containing topical/dermal/mucosal liquid?
30 days
What is a Type 1 error?
Type 1 error = false-positive –> the nullhypothesis is rejected in error –> think there is a difference but there isnt one
what is a Type 2 error?
Type II error = false negative –> the null hypothesis is accepted in error –> think that there is no difference but there acutally is.
What is Sensitivity?
Sensitivity = true positive –> how well a test identifies that you actually do have the condition.
What is Specificity?
Specificity = true negative, how well a test identifies that you do NOT have a condition. –> you Specifically do NOT have the disease
What class = reasonable probability that use will cause serious adverse health consequences/death?
Class I recall = reasonable probability that use will cause serious adverse health consequences/death
What class = probability of temporary/reversible adverse health consequences are remote?
Class II recall = probability of temporary/reversible adverse health consequences are remote
What class = Not likely to cause adverse health consequences?
Class III recall = Not likely to cause adverse health consequences
What is the Independent variable?
The independent variable = the intervention (ie., the drug)
What are the 3 first line drugs for ADHD?
Concerta, Vyvanse, Adderall XR
What is used 2nd line, or if abuse risk for ADHD?
Strattera
When do you use the Student/Unpaired T-test?
When Numerical/continuous Data, normal distribution, with Two groups
When do you use the ANOVA (or F-test)?
When Numerical/continuous Data, normal distribution, with three groups
Which Cost Analysis - Includes a quality of life (QALYs) component?
a. Cost minimization analysis (CMA)
b. Cost benefit Analysis (CBA)
c. Cost effectiveness Analysis
d. Cost Utility Analysis
Cost Utility Analysis - Includes a quality of life component
Which Cost Analysis - is used when two or more interventions have already demonstrated equivalency in outcomes and the costs of each intervention are being compared.
a. Cost minimization analysis (CMA)
b. Cost benefit Analysis (CBA)
c. Cost effectiveness Analysis
d. Cost Utility Analysis
Cost minimization analysis - is used when two or more interventions have already demonstrated equivalency in outcomes and the costs of each intervention are being compared.
Which Cost Analysis - have both the benefits and costs expressed in terms of dollars and are adjusted to their present value.
a. Cost minimization analysis (CMA)
b. Cost benefit Analysis (CBA)
c. Cost effectiveness Analysis
d. Cost Utility Analysis
Cost Benefit Analysis - have both the benefits and costs expressed in terms of dollars and are adjusted to their present value.
Which Cost Analysis - is defined as a series of analytical and mathematical procedures that aid in the selection of a course of action from various alternative approaches. Inputs are usually measured in dollars and outputs are usually measured in natural units.
a. Cost minimization analysis (CMA)
b. Cost benefit Analysis (CBA)
c. Cost effectiveness Analysis
d. Cost Utility Analysis
Cost effectiveness Analysis - is defined as a series of analytical and mathematical procedures that aid in the selection of a course of action from various alternative approaches. Inputs are usually measured in dollars and outputs are usually measured in natural units.
What is the dependent variable?
The dependent variable is what is affected by the independent variable. AKA the outcome of interest. change in BP, A1C, hemoglobin, ect.
What type of study compares pt with disease to those without disease. Retrospective?
a. Case-control
b. Cohort study
c. Cross-sectional survey
d. Case report and case series
E. Meta analysis
F. Randomized control
G. Systemic review
Case-control - type of study compares pt with disease to those without disease. Retrospective
What type of study compares outcomes of pt exposed to treatment and those not exposed to see if develop the outcome?
a. Case-control
b. Cohort study
c. Cross-sectional survey
d. Case report and case series
E. Meta analysis
F. Randomized control
G. Systemic review
Cohort study - type of study compares outcomes of pt exposed to treatment and those not exposed to see if develop the outcome. Prospective (more common) or retrospective
What type of study estimates relationship between variables and outcomes at one particular time?
a. Case-control
b. Cohort study
c. Cross-sectional survey
d. Case report and case series
E. Meta analysis
F. Randomized control
G. Systemic review
Cross-sectional survey - type of study estimates relationship between variables and outcomes at one particular time?
What type of study describes adverse reaction in a single patient or a few patients?
a. Case-control
b. Cohort study
c. Cross-sectional survey
d. Case report and case series
E. Meta analysis
F. Randomized control
G. Systemic review
Case report and case series - type of study describes adverse reaction in a single patient or a few patients
What order is the most reliable study?
a. Case-control
b. Cohort study
c. Cross-sectional survey
d. Case report and case series
E. Meta analysis
F. Randomized control
G. Systemic review
Most reliable Meta analysis Randomized control Cohort Case control Case reports Expert opinion
What type of study combines results from multiple studies in order to develop a conclusion that has greater statistical power than the individual studies
a. Case-control
b. Cohort study
c. Cross-sectional survey
d. Case report and case series
E. Meta analysis
F. Randomized control
G. Systemic review
Meta analysis - type of study combines results from multiple studies in order to develop a conclusion that has greater statistical power than the individual studies
What type of study compares an experimental treatment to the current or placebo to determine which is better?
a. Case-control
b. Cohort study
c. Cross-sectional survey
d. Case report and case series
E. Meta analysis
F. Randomized control
G. Systemic review
Randomized control - type of study compares an experimental treatment to the current or placebo to determine which is better
Gram positive, stain purple, clusters would likely be what?
MRSA/MSSA
What color do Gram Negative stain?
Gram negative = pink/red
What three groups of antibiotics are Cmax:MIC (Concentration dependent)?
aminoglycosides, quinolones, daptomycin
What Three groups of antibiotics are AUC:MIC
Vanc, Macrolides, tetracyclines
What Three groups of antibiotics are TIme>MIC
Penicillins, cephalosporins, carbapenems.
What is the drug of choice for syphilis?
Penicillin G benzathine (Bicillin L-A) = drug of choice for syphilis (2.4 million units IM x1)
What medication do you use for PCN allergy?
Aztreonam (Azactam) - can be ued with PCN allergy –> Only treats gram negative
What is the treatment for a neonate with meningitis?
neonate = ampicillin + cefotaxime OR gentamicin
Remember, no ceftriaxone in neonates < 28 days
What is the treatment for babies with meningitis?
Ceftriaxone + Vancomycin
What is the treatment for normal people 2-50 years old?
Ceftriaxone + Vancomycin
what is the treatment for elderly or immunocompromised with meningitis?
Ceftriaxone + Vancomycin + ampicillin
What do you for Meningitis if the pt has a PCN allergy?
quinolone + vancomycin +/- Bactrim
Outpatient CAP: pt hasn’t had abx in past 3 months and is previously healthy. what can you give?
Macrolide OR doxycycline
Outpatient CAP: pt has risk for drug resistant Strep pneumo or abx use within 3 months or chronic disease or immunocompromised. What can you give?
- Beta lactam + Macrolide
OR - Respiratory quinolone monotherapy (Moxifloxacin, gemifloxacin, or levofloxacin)
How should Opana ER (oxymorphone) be taken relative to food?
Opana ER should be taken on an empty stomach
What are the Five A’s for smoking cessation?
- Ask about tobacco use
- Advise to quit
- Assess willingness to make an attempt
- assist in quit attempt
- Arrange follow up
When do you start with 21mg nicotine patch vs the 14mg patch?
If > 10 cigs/day, start with 21 mg patch
If < 10, start with 14mg patch
What is a main SE of the nicotine patch?
Vivid dreams
When do you use 2mg nicotine gum vs the 4mg gum?
If the 1st cig > 30 min after waking up, use 2mg gum/lozenge
If 1st cig < 30 min after waking up, use 4mg gum/lozenge
For weeks 1-6 how often do you take the nicotine gum?
weeks 1-6 use Q1-2 hours
For weeks 7-9 how often do you take the nicotine gum?
Weeks 7-9 use q2-4hours
For weeks 10-12 how often do you take the nicotine gum?
weeks 10-12 use Q4-8hours
When do you start bupropion/chantix relative to the quit date?
start bupropion/Chantix 1 week before the quit date.
What is the cystic fibrosis treatment order?
cystic fibrosis treatment order –> Bronchodilator (albuterol), hypertonic saline, dornase alfa, chest physiotherapy, inhaled antibiotics (Tobramycin, oral azithromycin)
Is Creon and Lip-Prot-Amyl interchangeable?
Pancreatic enzyme products are NOT interchangeable. SO NO
What is the most common cause of Hypothyroid disease?
Hashimoto’s disease –> an autoimmune condition where pt antibodies attack their own thyroid gland
What will the FT4 and TSH labs show in Hypothyroidism?
Hypothyroidism will show low FT4 (Free thyroxine) and elevation in TSH(Thyroid stimulating hormone).
When should Levothyroxine be taken?
Levothyroxine should be taken with water consistently at least 60 minutes beofre breakfast or at bed time (at least 3 hours after the last meal).
What is the most common cause of Hyperthyroid disease?
Graves disease –> antibodies stimulate thyroid to produce too much T4
How do you treat myxedema coma?
myxedema coma –> treat with IV levothyroxine
How do you treat Thyroid storm?
Thyroid strom –> treat with propylthiouracil (PTU) + Iodide (SKKI or Lugol’s) + beta blocker (Propranolol) + systemic steroid + acetaminophen
What is the normal starting dose of levothyroxine?
normal pts start levothyroxine 1.6mcg/kg IBW
Pts with known CAD start levothyroxine 12.5-25mcg
Which steroid is used for Addison’s disease?
Fludrocortisone mimics aldosterone due to its mineralcorticoid activity that balances water and electrolytes. FDA approved for Addison’s disease. Used off-label for orthostasis.
What is the steroid conversion? Cortisone Hydrocortisone prednisone Prednisolone Methylprednisolone Triamcinolone Dexamethasone Betamethasone
Cortisone - 25 Hydrocortisone - 20 prednisone - 5 Prednisolone - 5 Methylprednisolone - 4 Triamcinolone - 4 Dexamethasone - 0.75 Betamethasone - 0.6
what is the relation of Cushing’s and Addison’s disease to cortisol?
Cushing's = too much cortisol Addison's = not enough cortisol
Allopurinol increases azathioprine (Azasan) concentration, how much should the dose be reduced by?
Allopurinol increases azathioprine concentration. Reduce dose of azathioprine ~75%
What is the maximum dose of Calcium due to saturability?
Max calcium dose at one time is 600mg due to saturability. Split doses.
Increased COX-2 selectivity = lower GI risk
Place in order of least GI risk
Celebrex, Relafen, Lodine, Voltaren, Mobic
Lower GI RIsk = Celecoxib (Celebrex) Diclofenac (Voltaren) Meloxicam (Mobic) Etodolac (Lodine) Nabumetone (Relafen)
What is preferred in a COPD, Asthma patient with glucoma?
Betaxolol (Betopic S) = preferred in COPD, asthma pt with glaucoma. Selective beta blocker.
What ANC value represents neutropenia?
neutropenia = ANC < 1000
What ANC value represents Severe neutropenia?
Severe neutropenia = ANC < 500
What ANC value represents Profound Neutropenia?
profound neutropenia = ANC < 100
What ANC value represents Profound Neutropenia?
profound neutropenia = ANC < 100
Why does Bleomycin have a max dose of 400 units?
Bleomycin = max dose 400 units = pulmonary toxicity
Why does doxorubicin have a max dose of 450-550 mg/m2?
doxorubicin = max dose 450-550 mg/m2 = cardiotoxicity
why does cisplatin have a max dose of 100mg/m2?
Cisplatin - dose per cycle NOT to exceed 100mg/m2 = nephrotoxicity
Why is vincristine’s dose capped at 2mg?
Vincristine = single dose capped at 2mg = neuropathy
What is a common SE of fluorouracil?
fluorouracil = hand foot syndrome
what is a common SE of methotrexate?
stomatitis/mucositis
How is the MCV related to anemia?
Low MCV = microcytic
High MCV = macrocytic
What is Macrocytic anemia caused by?
Macrocytic anemia is caused by b12 or folate deficiency
10 drugs/classes that can cause Hemolytic anemia?
beta-lactamase inhibitors, cephalosporins, isoniazid, levodopa, methyldopa, penicillins, platinum chemo drugs, quinidine, ribavirin, rifampin
what are 8 medications that are high risk with G6PD deficiency?
chloroquine, dapsone, methylene blue, nitrofurantoin, primaquine, probenecid, rasburicase, sulfonamides.
What is valbenazine (Ingrezza) approved for?
Valbenazine (Ingrezza) is approved for tardive dyskinesia
What is the common SE of Zyprexa?
olanzapine (zyprexa) = SE include metabolic abnormalities
What is the trough range for lithium?
lithium therapeutic range = 0.6-1.2 MEq/L (trough)
What are the three colors of the does for lamictal?
orange = standard starting dose Blue = lower starting dose = use if taking valproic acid green = higher starting dose = used if taking other enzyme inducer and NOT taking valproic acid
When should you call 911 for a seizure?
Call 911 if seizure lasts > 5 minutes
Focal vs generalized seizure?
Focal = starts on one side of the brain
Generalized starts on BOTH sides of the brain.
define status epilepticus
Status epilepticus is a seizure lasting ? 5 minutes and can cause brain damage/fatality
5-20 minutes into a seizure what can you give?
5-20 minutes = give IM midazolam OR IV lorazepam OR Rectal diazepam
20 40 minutes into a seizure what can you give?
20-40 minutes = give regular AED option (IV fosphenytoin, valoprooic acid, keppra, phenobarb if others not available
40+ minutes into a seizure what can you give?
40+ minutes = shit out of luck
Why should all patients on Anticonvulsants be supplemented with calcium and vit D?
Anticonvulsants depress electrical activity in the brain, cause BONE loss and increased Fracture risk. All pts should be supplemented with calcium and vit D.
What does Depakote (Valproic acid) have a BBW for?
Depakote (valproic acid) = BBW for hepatotoxicity
How must phenytoin be given?
Phenytoin = normal saline only + filter needle
primidone (mysoline) is a prodrug of?
Primidone (mysoline) is a prodrug of phenobarbital
Which dhp CCB is more selective for cerebral arteries due to its increased lipophilicity and is PO ONLY?
nimodipine (Nymalize) = dhp CCB that is more selective for cerebral arteries due to its increased lipophilicity and is PO ONLY
What are the ONLY two IV PPIs?
only two IV PPIs = esomeprazole and pantoprazole
Which USP is used for Hazardous drugs?
USP 800. ASHP provides guidance for implementing these standards
What are the Three types of hazardous drugs (HD)?
Three type of hazardous drugs (HD) = Antineoplastic(Cancer drugs), non-antineoplastic (hormones, transplant), and drugs with reproductive risk.
What is an error of omission?
error of omission = something was left out that is needed for safety
What is an error of commission?
error of commission = something was done incorrectly
When should you use Soap and water instead of alcohol based rubs
- Before eating
- After using the restroom
- anytime there is visible soil
- After caring for a C. diff patient
- before caring for a pt with food allergies
What are Type A and Type B adverse drug reactions?
Adverse drug reactions = predictable (Type A) and unpredictable (Type B)
What is the Naranjo scale?
Naranjo scale (causality assessment scale) helps determine likelihood a drug caused an adverse reaction.
What is the name of the FDA’s adverse drug reaction reporting program?
Side effects, adverse events, and allergies should be reported to FDA’s MedWatch program = FDA adverse event reporting system (FAERS)
How do you treat a preggo pt with syphilis and penicillin allergy?
Preggo pt with syphilis and penicillin allergy should be desensitized and treated
The amount of drug removed per hour is the same - describes what kind of kinetics?
Zero order kinetics = amount of drug removed per hour is the same (eg., 300mg)
The percent of drug removed per hour is the same - describes what kind of kinetics
First order kinetics = percent of drug removed per hour is the same (eg.,15%)
Give 3 examples of drugs that follow non-linear/saturable /mixed/michaelis-menten kinetics
Voriconazole, phenytoin, theophylline
= doubling the dose can more than double serum concentrations
How do you treat shock?
- Fill the tank (Optimize preload with IV crystalloid bolus)
- Squeeze the pipes (peripheral vasoconstrictor with alpha-1 agonist(phenylephrine) to increase SVR))
- Kick the pump (beta-1 agonist to increase myocardial contractility and CO)
How many mcg of folic acid do preggo’s need? How much do women of child bearing age need?
preggo women need 600mcg/day folic acid
Women of child bearing age need 400mcg/day
How much calcium and vitamin D do Preggo’s need?
preggo women need 1000mg/day of calcium and 600 IU/day of Vitamin D.
What 3 medications should you use for HTN in preggos?
Labetolol, methyldopa, nifedipine
How much do you need to increase the dose of levothyroxine during pregnancy?
Need to increase levothyroxine 30-50% during pregnancy
If drugs needed for hyperthyroidism in during pregnancy what do you use?
if drugs need for hyperthyroidism, use PTU in 1st trimester and methimazole in 2nd and 3rd trimester.
Babies receiving breast milk need how many IU of vitamin D until the are consuming 1 liter vitamin D fortified formula per day?
Babies receiving breast milk need 400IU of vitamin D until the are consuming 1 liter vitamin D fortified formula per day
How much Iron should babies receive during the first 4-6 months?
Breastfed babies also need 1mg/kg iron during months 4-6.
What can procainamide and quinidine cause?
Procainamide and quinidine can cause lupus
what are the Class I (NA blockers) used for arrhythmias?
1a. Disopyramide, quinidine, procainamide
1b. lidocaine, mexiletine
1c. Flecainide, propafenone
What are the Class II Anti arrhythmic drugs?
Beta blockers
What are the class III (K block) anti arrhythmic drugs
dronedarone, dofetilide, sotalol, ibutilide, amiodarone
What are the class IV Anti arrhythmic drugs
Verapamil, diltiazem
What is the VTE prophylaxis dose of Heparin?
VTE prophylaxis = 5000 units SQ Q8-12H
What is the VTE treatment dose of Heparin?
VTE treatment = 80units/kg IV bolus + 18units/kg/hr
What is heparin ACS/STEMI treatment dose?
ACS/STEMI treatment = 60units/kg IV bolus + 12 units/kg/hr
What is the antidote used for heparin toxicity?
Heparin antidote = protamine sulfate
When do take enoxaparin anti-Xa levels?
Enoxaparin anti-XA levels = take a peak level 4 hours post dose
drugs/classes that can raise blood sugar (12)
Azoles Beta agoinst Beta blockers Diuretics Tacrolimus/cyclosporine niacin protease inhibitors quinolones antipsychotics statins steroids
