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Oncology Flashcards

1
Q

At what age should Females begin to have yearly mamograms?

A. 40-44 years
B. 44-54 years
C. > 50 years 
D. > 55 years 
E. 55-74 years
A

B 44-54 years

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2
Q

When should F/M start having a Colonoscopy every 10 years?

A. 40-44 years
B. 44-54 years
C. > 50 years 
D. > 55 years 
E. 55-74 years
A

C. > 50 years

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3
Q

What is the lifetime cumulative dose of Bleomycin?

A. 450 -550 mg/m2
B. 100mg/m2
C. 400 units
D. 2mg

A

C. 400 units

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4
Q

What is the lifetime cumulative dose of Doxorubicin?

A. 450 -550 mg/m2
B. 100mg/m2
C. 400 units
D. 2mg

A

A. 450 -550 mg/m2

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5
Q

What is the limited dose per cycle of Cisplatin?

A. 450 -550 mg/m2
B. 100mg/m2
C. 400 units
D. 2mg

A

B. 100mg/m2

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6
Q

What is the single dose cap of Vincristine?

A. 450 -550 mg/m2
B. 100mg/m2
C. 400 units
D. 2mg

A

D. 2mg

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7
Q

Which of the following do NOT cause Myelosuppression

A. Methotrexate
B. Asparaginase
C. bleomycin
D. vincristine

A

B. Asparaginase
C. bleomycin
D. vincristine

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8
Q

Which of the following is Highly emetogenic?

A. Methotrexate
B. Cisplatin
C. bleomycin
D. Irinotecan

A

B. Cisplatin

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9
Q

Which of the following Inhibits Dihydrofolate Reductase?

A. Methotrexate
B. 6-Mercaptopurine
C. 6-Thioguanine
D. 5-Fluorouracil 
E. Cytarabine
A

A. Methotrexate

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10
Q

Which of the following decreases Thimydialte synthesis?

A. Methotrexate
B. 6-Mercaptopurine
C. 6-Thioguanine
D. 5-Fluorouracil 
E. Cytarabine
A

D. 5-Fluorouracil

5-FU say FU to Thimydilate synthesis

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11
Q

Which of the following decrease Purine synthesis?

A. Methotrexate
B. 6-Mercaptopurine
C. 6-Thioguanine
D. 5-Fluorouracil 
E. Cytarabine
A

B. 6-Mercaptopurine

C. 6-Thioguanine

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12
Q

Which of the following decrease DNA polymerase?

A. Methotrexate
B. 6-Mercaptopurine
C. 6-Thioguanine
D. 5-Fluorouracil 
E. Cytarabine
A

E. Cytarabine

Tara likes double penetration (DP) —DNA polymerase

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13
Q

Which of the following cause myelosuppression that is reversible with Leucovorin?

A. Methotrexate
B. 6-Mercaptopurine
C. 6-Thioguanine
D. 5-Fluorouracil 
E. Cytarabine
A

A. Methotrexate - causes myelosuppression that is reversible with Leucovorin

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14
Q 
Which of the following is broken down by Xanthine Oxidase? 
A. Methotrexate
B. 6-Mercaptopurine
C. 6-Thioguanine
D. 5-Fluorouracil 
E. Cytarabine
A

B. 6-Mercaptopurine is broken down by Xanthine Oxidase – which is inhibited by Allopurinol

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15
Q

Methotrexate causes myelosuppression that is reversible with ?

A

Leucovorin

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16
Q

Which of the following would have increased toxicity if it was administered along side Allopurinol?

A. Methotrexate
B. 6-Mercaptopurine
C. 6-Thioguanine
D. 5-Fluorouracil 
E. Cytarabine
A

B. 6-Mercaptopurine is broken down by Xanthine Oxidase – which is inhibited by Allopurinol

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17
Q

Which of the following cause Diarrhea?

A. 5 - FU
B. Vincristine
C. Capecitabine
D. Pomalidomide
E. Irinotecan
F. Thalidomide
A

A. 5 - FU
C. Capecitabine
E. Irinotecan

18
Q

Which of the following cause Constipation?

A. 5 - FU
B. Vincristine
C. Capecitabine
D. Pomalidomide
E. Irinotecan
F. Thalidomide
A

B. Vincristine
D. Pomalidomide
F. Thalidomide

19
Q

Bleomycin, Busulfan, Carmustine, Lomustine cause which of the following?

A. Mucositis
B. Hemorrhagic Cystitis
C. Pulmonary Fibrosis
D. Cardiotoxicity 
E. Ototoxic
F. Nephrotoxic
G. Peripheral Neuropathy 
H. Neurotoxic (Cross blood brain barrier)
A

C. Pulmonary Fibrosis

20
Q

Cisplatin, Carboplatin cause which of the following?

A. Mucositis
B. Hemorrhagic Cystitis
C. Pulmonary Fibrosis
D. Cardiotoxicity 
E. Ototoxic
F. Nephrotoxic
G. Peripheral Neuropathy 
H. Neurotoxic (Cross blood brain barrier)
A

E. Ototoxic

F. Nephrotoxic

21
Q

Doxorubicin and Danorubicin cause which of the following?

A. Mucositis
B. Hemorrhagic Cystitis
C. Pulmonary Fibrosis
D. Cardiotoxicity 
E. Ototoxic
F. Nephrotoxic
G. Peripheral Neuropathy 
H. Neurotoxic (Cross blood brain barrier)
A

D. Cariotoxicity – is reversible with Dexrazoxane

22
Q

Methotrexate and, 5-FU cause which of the following?

A. Mucositis
B. Hemorrhagic Cystitis
C. Pulmonary Fibrosis
D. Cardiotoxicity 
E. Ototoxic
F. Nephrotoxic
G. Peripheral Neuropathy 
H. Neurotoxic (Cross blood brain barrier)
A

A. Mucositis

23
Q

lomustine, and carmustine cause which of the following?

A. Mucositis
B. Hemorrhagic Cystitis
C. Pulmonary Fibrosis
D. Cardiotoxicity 
E. Ototoxic
F. Nephrotoxic
G. Peripheral Neuropathy 
H. Neurotoxic (Cross blood brain barrier)
A

H. Neurotoxic (Cross blood brain barrier)
Also
C. Pulmonary toxicity

24
Q

Ifosfamide and Cyclophosphamide cause which of the following?

A. Mucositis
B. Hemorrhagic Cystitis
C. Pulmonary Fibrosis
D. Cardiotoxicity 
E. Ototoxic
F. Nephrotoxic
G. Peripheral Neuropathy 
H. Neurotoxic (Cross blood brain barrier)
A

B. Hemorrhagic Cystitis

25
Vincristine, Vinblastine and Paclitaxel and Docetaxel cause which of the following? ``` A. Mucositis B. Hemorrhagic Cystitis C. Pulmonary Fibrosis D. Cardiotoxicity E. Ototoxic F. Nephrotoxic G. Peripheral Neuropathy H. Neurotoxic (Cross blood brain barrier) ```
G. Peripheral Neuropathy
26
Pts that experience Hemorrhagic cystitis caused by cyclophosphamide can reverse it with what medication?
Mesna (Mesnex)
27
Pts taking Cisplatin should be given this to help prevent nephrotoxicity? ``` A. Amifostine B. Cinecard C. Dexrazoxane D. Zinecard E. Ethyol F. Fusilev G. Leucovorin ```
A. Amifostine | E. Ethyol -- brand name of Amifostine
28
Pts taking Doxorubicin should take this to prevent cardiomyopathy ``` A. Amifostine B. Cinecard C. Dexrazoxane D. Zinecard E. Ethyol F. Fusilev G. Leucovorin ```
C. Dexrazoxane | D. Zinecard -- brand name of Dexrazoxane
29
which of the following may be given with Fluorouracil to enhance efficacy? ``` A. Amifostine B. Cinecard C. Dexrazoxane D. Zinecard E. Ethyol F. Fusilev G. Leucovorin ```
G. Leucovorin | F. Fusilev --> Levoleucovorin
30
Which of the following can be given as prophylaxis prevent hemorrhagic cystitis caused by Ifosfamide? ``` A. Amifostine B. Atropine C. Loperamide D. Zinecard E. Leucovorin F. Mesna (Mesnex) ```
F. Mesna (Mesnex)
31
Which of the following can be given to prevent or treat acute diarrhea caused by Irinotecan? ``` A. Amifostine B. Atropine C. Loperamide D. Zinecard E. Leucovorin F. Mesna (Mesnex) ```
B. Atropine | C. Loperamide
32
Which of the follwing causes red urine discoloriation? ``` A. Bleomycin B. Dactinomycin C. Etoposide D. Paclitaxel E. Doxorubicin F. Vinblastine G. Mitoxantrone ```
E. Doxorubicin
33
Which of the following causes blue urine discoloration? ``` A. Bleomycin B. Dactinomycin C. Etoposide D. Paclitaxel E. Doxorubicin F. Vinblastine G. Mitoxantrone ```
G. Mitoxantrone
34
Vinca alkaloids and Taxanes work on which phase of the cell cycle? ``` A. G0 phase B. G1 phase C. S phase D. G2 phase and S phase E. M phase F. Non - cell cycle specific ```
E. M phase
35
Etoposide and Bleomycin work on which phase of the cell cycle? ``` A. G0 phase B. G1 phase C. S phase D. G2 phase and S phase E. M phase F. Non - cell cycle specific ```
D. G2 phase and S phase
36
Irinotecan, Methotrexate, and 5-FU work on which phase of the cell cycle? ``` A. G0 phase B. G1 phase C. S phase D. G2 phase and S phase E. M phase F. Non - cell cycle specific ```
C. S phase
37
What is the reason for a life time cumulative dose of 400 units for Bleomycin? A. Cardiotoxicity B. Nephrotoxicity C. Pulmonary toxicity D. Neuropathy
C. Pulmonary toxicity
38
What is the reason for a life time cumulative dose of 450 -550 mg/m2 for doxorubicin? A. Cardiotoxicity B. Nephrotoxicity C. Pulmonary toxicity D. Neuropathy
A. Cardiotoxicity
39
what is the reason for the dose per cycle of Cisplatin to not exceed 100 mg/m2? A. Cardiotoxicity B. Nephrotoxicity C. Pulmonary toxicity D. Neuropathy
B. Nephrotoxicity
40
What is the reason for the single dose cap of 2mg for Vincristine? A. Cardiotoxicity B. Nephrotoxicity C. Pulmonary toxicity D. Neuropathy
D. Neuropathy

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