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Things to know > Oncology > Flashcards

Oncology Flashcards

1
Q

At what age should Females begin to have yearly mamograms?

A. 40-44 years
B. 44-54 years
C. > 50 years 
D. > 55 years 
E. 55-74 years
A

B 44-54 years

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2
Q

When should F/M start having a Colonoscopy every 10 years?

A. 40-44 years
B. 44-54 years
C. > 50 years 
D. > 55 years 
E. 55-74 years
A

C. > 50 years

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3
Q

What is the lifetime cumulative dose of Bleomycin?

A. 450 -550 mg/m2
B. 100mg/m2
C. 400 units
D. 2mg

A

C. 400 units

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4
Q

What is the lifetime cumulative dose of Doxorubicin?

A. 450 -550 mg/m2
B. 100mg/m2
C. 400 units
D. 2mg

A

A. 450 -550 mg/m2

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5
Q

What is the limited dose per cycle of Cisplatin?

A. 450 -550 mg/m2
B. 100mg/m2
C. 400 units
D. 2mg

A

B. 100mg/m2

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6
Q

What is the single dose cap of Vincristine?

A. 450 -550 mg/m2
B. 100mg/m2
C. 400 units
D. 2mg

A

D. 2mg

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7
Q

Which of the following do NOT cause Myelosuppression

A. Methotrexate
B. Asparaginase
C. bleomycin
D. vincristine

A

B. Asparaginase
C. bleomycin
D. vincristine

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8
Q

Which of the following is Highly emetogenic?

A. Methotrexate
B. Cisplatin
C. bleomycin
D. Irinotecan

A

B. Cisplatin

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9
Q

Which of the following Inhibits Dihydrofolate Reductase?

A. Methotrexate
B. 6-Mercaptopurine
C. 6-Thioguanine
D. 5-Fluorouracil 
E. Cytarabine
A

A. Methotrexate

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10
Q

Which of the following decreases Thimydialte synthesis?

A. Methotrexate
B. 6-Mercaptopurine
C. 6-Thioguanine
D. 5-Fluorouracil 
E. Cytarabine
A

D. 5-Fluorouracil

5-FU say FU to Thimydilate synthesis

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11
Q

Which of the following decrease Purine synthesis?

A. Methotrexate
B. 6-Mercaptopurine
C. 6-Thioguanine
D. 5-Fluorouracil 
E. Cytarabine
A

B. 6-Mercaptopurine

C. 6-Thioguanine

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12
Q

Which of the following decrease DNA polymerase?

A. Methotrexate
B. 6-Mercaptopurine
C. 6-Thioguanine
D. 5-Fluorouracil 
E. Cytarabine
A

E. Cytarabine

Tara likes double penetration (DP) —DNA polymerase

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13
Q

Which of the following cause myelosuppression that is reversible with Leucovorin?

A. Methotrexate
B. 6-Mercaptopurine
C. 6-Thioguanine
D. 5-Fluorouracil 
E. Cytarabine
A

A. Methotrexate - causes myelosuppression that is reversible with Leucovorin

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14
Q 
Which of the following is broken down by Xanthine Oxidase? 
A. Methotrexate
B. 6-Mercaptopurine
C. 6-Thioguanine
D. 5-Fluorouracil 
E. Cytarabine
A

B. 6-Mercaptopurine is broken down by Xanthine Oxidase – which is inhibited by Allopurinol

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15
Q

Methotrexate causes myelosuppression that is reversible with ?

A

Leucovorin

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16
Q

Which of the following would have increased toxicity if it was administered along side Allopurinol?

A. Methotrexate
B. 6-Mercaptopurine
C. 6-Thioguanine
D. 5-Fluorouracil 
E. Cytarabine
A

B. 6-Mercaptopurine is broken down by Xanthine Oxidase – which is inhibited by Allopurinol

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17
Q

Which of the following cause Diarrhea?

A. 5 - FU
B. Vincristine
C. Capecitabine
D. Pomalidomide
E. Irinotecan
F. Thalidomide
A

A. 5 - FU
C. Capecitabine
E. Irinotecan

18
Q

Which of the following cause Constipation?

A. 5 - FU
B. Vincristine
C. Capecitabine
D. Pomalidomide
E. Irinotecan
F. Thalidomide
A

B. Vincristine
D. Pomalidomide
F. Thalidomide

19
Q

Bleomycin, Busulfan, Carmustine, Lomustine cause which of the following?

A. Mucositis
B. Hemorrhagic Cystitis
C. Pulmonary Fibrosis
D. Cardiotoxicity 
E. Ototoxic
F. Nephrotoxic
G. Peripheral Neuropathy 
H. Neurotoxic (Cross blood brain barrier)
A

C. Pulmonary Fibrosis

20
Q

Cisplatin, Carboplatin cause which of the following?

A. Mucositis
B. Hemorrhagic Cystitis
C. Pulmonary Fibrosis
D. Cardiotoxicity 
E. Ototoxic
F. Nephrotoxic
G. Peripheral Neuropathy 
H. Neurotoxic (Cross blood brain barrier)
A

E. Ototoxic

F. Nephrotoxic

21
Q

Doxorubicin and Danorubicin cause which of the following?

A. Mucositis
B. Hemorrhagic Cystitis
C. Pulmonary Fibrosis
D. Cardiotoxicity 
E. Ototoxic
F. Nephrotoxic
G. Peripheral Neuropathy 
H. Neurotoxic (Cross blood brain barrier)
A

D. Cariotoxicity – is reversible with Dexrazoxane

22
Q

Methotrexate and, 5-FU cause which of the following?

A. Mucositis
B. Hemorrhagic Cystitis
C. Pulmonary Fibrosis
D. Cardiotoxicity 
E. Ototoxic
F. Nephrotoxic
G. Peripheral Neuropathy 
H. Neurotoxic (Cross blood brain barrier)
A

A. Mucositis

23
Q

lomustine, and carmustine cause which of the following?

A. Mucositis
B. Hemorrhagic Cystitis
C. Pulmonary Fibrosis
D. Cardiotoxicity 
E. Ototoxic
F. Nephrotoxic
G. Peripheral Neuropathy 
H. Neurotoxic (Cross blood brain barrier)
A

H. Neurotoxic (Cross blood brain barrier)
Also
C. Pulmonary toxicity

24
Q

Ifosfamide and Cyclophosphamide cause which of the following?

A. Mucositis
B. Hemorrhagic Cystitis
C. Pulmonary Fibrosis
D. Cardiotoxicity 
E. Ototoxic
F. Nephrotoxic
G. Peripheral Neuropathy 
H. Neurotoxic (Cross blood brain barrier)
A

B. Hemorrhagic Cystitis

25
Q

Vincristine, Vinblastine and Paclitaxel and Docetaxel cause which of the following?

A. Mucositis
B. Hemorrhagic Cystitis
C. Pulmonary Fibrosis
D. Cardiotoxicity 
E. Ototoxic
F. Nephrotoxic
G. Peripheral Neuropathy 
H. Neurotoxic (Cross blood brain barrier)
A

G. Peripheral Neuropathy

26
Q

Pts that experience Hemorrhagic cystitis caused by cyclophosphamide can reverse it with what medication?

A

Mesna (Mesnex)

27
Q

Pts taking Cisplatin should be given this to help prevent nephrotoxicity?

A. Amifostine
B. Cinecard
C. Dexrazoxane
D. Zinecard
E. Ethyol 
F. Fusilev
G. Leucovorin
A

A. Amifostine

E. Ethyol – brand name of Amifostine

28
Q

Pts taking Doxorubicin should take this to prevent cardiomyopathy

A. Amifostine
B. Cinecard
C. Dexrazoxane
D. Zinecard
E. Ethyol 
F. Fusilev
G. Leucovorin
A

C. Dexrazoxane

D. Zinecard – brand name of Dexrazoxane

29
Q

which of the following may be given with Fluorouracil to enhance efficacy?

A. Amifostine
B. Cinecard
C. Dexrazoxane
D. Zinecard
E. Ethyol 
F. Fusilev
G. Leucovorin
A

G. Leucovorin

F. Fusilev –> Levoleucovorin

30
Q

Which of the following can be given as prophylaxis prevent hemorrhagic cystitis caused by Ifosfamide?

A. Amifostine
B. Atropine
C. Loperamide
D. Zinecard
E. Leucovorin
F. Mesna (Mesnex)
A

F. Mesna (Mesnex)

31
Q

Which of the following can be given to prevent or treat acute diarrhea caused by Irinotecan?

A. Amifostine
B. Atropine
C. Loperamide
D. Zinecard
E. Leucovorin
F. Mesna (Mesnex)
A

B. Atropine

C. Loperamide

32
Q

Which of the follwing causes red urine discoloriation?

A. Bleomycin
B. Dactinomycin
C. Etoposide
D. Paclitaxel
E. Doxorubicin
F. Vinblastine 
G. Mitoxantrone
A

E. Doxorubicin

33
Q

Which of the following causes blue urine discoloration?

A. Bleomycin
B. Dactinomycin
C. Etoposide
D. Paclitaxel
E. Doxorubicin
F. Vinblastine 
G. Mitoxantrone
A

G. Mitoxantrone

34
Q

Vinca alkaloids and Taxanes work on which phase of the cell cycle?

A. G0 phase
B. G1 phase
C. S phase 
D. G2 phase and S phase
E.  M phase 
F. Non - cell cycle specific
A

E. M phase

35
Q

Etoposide and Bleomycin work on which phase of the cell cycle?

A. G0 phase
B. G1 phase
C. S phase 
D. G2 phase and S phase
E.  M phase 
F. Non - cell cycle specific
A

D. G2 phase and S phase

36
Q

Irinotecan, Methotrexate, and 5-FU work on which phase of the cell cycle?

A. G0 phase
B. G1 phase
C. S phase 
D. G2 phase and S phase
E.  M phase 
F. Non - cell cycle specific
A

C. S phase

37
Q

What is the reason for a life time cumulative dose of 400 units for Bleomycin?

A. Cardiotoxicity
B. Nephrotoxicity
C. Pulmonary toxicity
D. Neuropathy

A

C. Pulmonary toxicity

38
Q

What is the reason for a life time cumulative dose of 450 -550 mg/m2 for doxorubicin?

A. Cardiotoxicity
B. Nephrotoxicity
C. Pulmonary toxicity
D. Neuropathy

A

A. Cardiotoxicity

39
Q

what is the reason for the dose per cycle of Cisplatin to not exceed 100 mg/m2?

A. Cardiotoxicity
B. Nephrotoxicity
C. Pulmonary toxicity
D. Neuropathy

A

B. Nephrotoxicity

40
Q

What is the reason for the single dose cap of 2mg for Vincristine?

A. Cardiotoxicity
B. Nephrotoxicity
C. Pulmonary toxicity
D. Neuropathy

A

D. Neuropathy

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