Antifungals and Antivirals Flashcards
Which of the following works by binding to ergosterol, altering cell membrane permeability and causing cell death?
A. Nystatin B. Azole Antifungals C. Clotrimazole D. Flucytsoine E. Echinocandins F. Amphotericin B G. Griseofulvin
F. Amphotericin B
Which of the following works by penetrating fungal cells and interfering with fungal RNA and protein synthesis?
A. Nystatin B. Azole Antifungals C. Clotrimazole D. Flucytsoine E. Echinocandins F. Amphotericin B G. Griseofulvin
D. Flucytsoine it is converted to Fluorouracil 5-FU in the cell.
Which of the Following work by decreasing ergosterol synthesis and inhibit cell membrane formation?
A. Nystatin B. Azole Antifungals C. Clotrimazole D. Flucytsoine E. Echinocandins F. Amphotericin B G. Griseofulvin
B. Azole Antifungals
Which of the following work by inhibiting Beta 1,3 D glucan?
A. Nystatin B. Azole Antifungals C. Clotrimazole D. Flucytsoine E. Echinocandins F. Amphotericin B G. Griseofulvin
E. Echinocandins
Which of the Following work by decreasing ergosterol synthesis and inhibit cell membrane formation?
A. Nystatin B. Ketoconazole C. Clotrimazole D. Flucytsoine E. Fluconazole F. Amphotericin B G. Griseofulvin H. Caspofungin I. Voriconacole J. Isavuconazonium K. Micafungin L. Anidulafungin M. Posaconazole N. Itraconazole
Azole Anti fungals
B. Ketoconazole
E. Fluconazole
I. Voriconacole
J. Isavuconazonium
M. Posaconazole
N. Itraconazole
Which of the following work by inhibiting Beta 1,3 D glucan?
A. Nystatin B. Ketoconazole C. Clotrimazole D. Flucytsoine E. Fluconazole F. Amphotericin B G. Griseofulvin H. Caspofungin I. Voriconacole J. Isavuconazonium K. Micafungin L. Anidulafungin M. Posaconazole N. Itraconazole
Echinocandins
H. Caspofungin
K. Micafungin
L. Anidulafungin
Match the following Generics with the Brands
Anidulafungin Ketoconazole Caspofungin Fluconazole Isavuconazonium Itraconazole Micafungin Posaconazole Voriconazole ---------------------------------- Nizoral Diflucan Ketodan Xolegel Sporanox Vfed Noxafil Cresemba Cancidas Mycamine Eraxis
Anidulafungin -- Eraxis Ketoconazole -- Nizoral, Ketodan, Xolegel (all brands are topicals) Caspofungin -- Cancidas Fluconazole -- Diflucan Isavuconazonium -- Cresemba Itraconazole -- Sporanox Micafungin -- Mycamine Posaconazole -- Noxafil Voriconazole -- Vfed
Which class of medications is ONLY available as IV?
A. Azoles
B. Amphotericin B
C. Flucytosine
D. Echinocandins
D. Echinocandins
Which Azole Does NOT cause QT prolongation?
A. Ketoconazole B. Fluconazole C. Itraconazole D. Voriconazole E. Posaconazole F. Isavuconazonium G. Ketodan H. Diflucan I. Vfend J. Cresemba K. Noxafil
F. Isavuconazonium = Cresemba
J. Cresemba
Which is the Only Azole that requires renal dose adjustment?
A. Ketoconazole B. Fluconazole C. Itraconazole D. Voriconazole E. Posaconazole F. Isavuconazonium G. Ketodan H. Diflucan I. Vfend J. Cresemba K. Noxafil
B. Fluconazole = Diflucan
H. Diflucan
CrCl < 50 reduce the dose by 50%
Which of the following is the Drug of Choice for Aspergillus?
A. Ketoconazole B. Fluconazole C. Itraconazole D. Voriconazole E. Posaconazole F. Isavuconazonium G. Ketodan H. Diflucan I. Vfend J. Cresemba K. Noxafil
D. Voriconazole = Vfend
I. Vfend
Which of the following is useful for vaginal candidiasis in non pregnant patients?
A. Ketoconazole B. Fluconazole C. Itraconazole D. Voriconazole E. Posaconazole F. Isavuconazonium G. Ketodan H. Diflucan I. Vfend J. Cresemba K. Noxafil
B. Fluconazole
H. Diflucan
Which of the following do you need to monitor for visual changes and phototoxicity?
A. Ketoconazole B. Fluconazole C. Itraconazole D. Voriconazole E. Posaconazole F. Isavuconazonium G. Ketodan H. Diflucan I. Vfend J. Cresemba K. Noxafil
D. Voriconazole
I. Vfend
Which of the is active against molds including Aspergillus and zygomycetes?
A. Ketoconazole B. Fluconazole C. Itraconazole D. Voriconazole E. Posaconazole F. Isavuconazonium G. Ketodan H. Diflucan I. Vfend J. Cresemba K. Noxafil
E. Posaconazole = Noxafil
K. Noxafil
Which of the medications suspension has less bioavailability then its tablet dose?
A. Ketoconazole B. Fluconazole C. Itraconazole D. Voriconazole E. Posaconazole F. Isavuconazonium G. Ketodan H. Diflucan I. Vfend J. Cresemba K. Noxafil
E. Posaconazole
K. Noxafil
Which of the following is used for the treatment of Histoplasma capsulatum?
A. Clotrimazole, nystatin
B. PO Fluconazole
C. Fluconazole or echinocandin
D. Echinocandin (Preferred), Fluconazole (alternative)
E. Echinocandin (Preferred), Amphotericin B, Fluconzole (alternative)
F. Echinocadins or Amphotericin B
G. Voriconazole (Preferred), liposomal amphotericin B, isavuconazonium
H. Amphotericin B + flucytosine (5-fC)
I. Fluconazole (prolonged)
K. Fluconazole, itraconazole or amphotericin B
L. Liposomal amphotericin B followed by itaconazole
M. Amphotericin B +- posaconazole, isavuconazonium
N. Itraconazole, terbinafine, or fluconazole
L. Liposomal amphotericin B followed by itaconazole
Which for of Amphotericin B has more side effects and therefore requires a smaller dose to be used?
A. Amphotericin B deoxycholate
B. Amphotericin B Lipid Complex (Abelcet)
C. Liposomal Amphotericin B (Ambisome)
D. Amphotericn B cholesteryl sulfate complex
A. Amphotericin B deoxycholate (Convetional Formulation), The lipid formulations have less severe side effects and can are given in high doses
BBW for mixing up the formulations
Which of the following is used for the treatment of a mild case of oropharyngeal infection (Thrush)?
A. Clotrimazole, nystatin
B. PO Fluconazole
C. Fluconazole or echinocandin
D. Echinocandin (Preferred), Fluconazole (alternative)
E. Echinocandin (Preferred), Amphotericin B, Fluconzole (alternative)
F. Echinocadins or Amphotericin B
G. Voriconazole (Preferred), liposomal amphotericin B, isavuconazonium
H. Amphotericin B + flucytosine (5-fC)
I. Fluconazole (prolonged)
K. Fluconazole, itraconazole or amphotericin B
L. Liposomal amphotericin B followed by itaconazole
M. Amphotericin B +- posaconazole, isavuconazonium
N. Itraconazole, terbinafine, or fluconazole
A. Clotrimazole, nystatin
Topical versions
Which of the following is used for the treatment of a severe case of oropharyngeal infection (Thrush)?
A. Clotrimazole, nystatin
B. PO Fluconazole
C. Fluconazole or echinocandin
D. Echinocandin (Preferred), Fluconazole (alternative)
E. Echinocandin (Preferred), Amphotericin B, Fluconzole (alternative)
F. Echinocadins or Amphotericin B
G. Voriconazole (Preferred), liposomal amphotericin B, isavuconazonium
H. Amphotericin B + flucytosine (5-fC)
I. Fluconazole (prolonged)
K. Fluconazole, itraconazole or amphotericin B
L. Liposomal amphotericin B followed by itaconazole
M. Amphotericin B +- posaconazole, isavuconazonium
N. Itraconazole, terbinafine, or fluconazole
B. PO Fluconazole
Which of the following is used for the treatment of Zygomycetes class (Rhizopus, mucor)?
A. Clotrimazole, nystatin
B. PO Fluconazole
C. Fluconazole or echinocandin
D. Echinocandin (Preferred), Fluconazole (alternative)
E. Echinocandin (Preferred), Amphotericin B, Fluconzole (alternative)
F. Echinocadins or Amphotericin B
G. Voriconazole (Preferred), liposomal amphotericin B, isavuconazonium
H. Amphotericin B + flucytosine (5-fC)
I. Fluconazole (prolonged)
K. Fluconazole, itraconazole or amphotericin B
L. Liposomal amphotericin B followed by itaconazole
M. Amphotericin B +- posaconazole, isavuconazonium
N. Itraconazole, terbinafine, or fluconazole
M. Amphotericin B +- posaconazole, isavuconazonium
Which of the following is used for the treatment of Dematophytes (Nail bed infections)?
A. Clotrimazole, nystatin
B. PO Fluconazole
C. Fluconazole or echinocandin
D. Echinocandin (Preferred), Fluconazole (alternative)
E. Echinocandin (Preferred), Amphotericin B, Fluconzole (alternative)
F. Echinocadins or Amphotericin B
G. Voriconazole (Preferred), liposomal amphotericin B, isavuconazonium
H. Amphotericin B + flucytosine (5-fC)
I. Fluconazole (prolonged)
K. Fluconazole, itraconazole or amphotericin B
L. Liposomal amphotericin B followed by itaconazole
M. Amphotericin B +- posaconazole, isavuconazonium
N. Itraconazole, terbinafine, or fluconazole
N. Itraconazole, terbinafine, or fluconazole
Which of the following is used for the treatment of Aspergilus?
A. Clotrimazole, nystatin
B. PO Fluconazole
C. Fluconazole or echinocandin
D. Echinocandin (Preferred), Fluconazole (alternative)
E. Echinocandin (Preferred), Amphotericin B, Fluconzole (alternative)
F. Echinocadins or Amphotericin B
G. Voriconazole (Preferred), liposomal amphotericin B, isavuconazonium
H. Amphotericin B + flucytosine (5-fC)
I. Fluconazole (prolonged)
K. Fluconazole, itraconazole or amphotericin B
L. Liposomal amphotericin B followed by itaconazole
M. Amphotericin B +- posaconazole, isavuconazonium
N. Itraconazole, terbinafine, or fluconazole
G. Voriconazole (Preferred), liposomal amphotericin B, isavuconazonium
Which of the following is used for the treatment of a blood stream infection in a patient that is NOT neutropenic?
A. Clotrimazole, nystatin
B. PO Fluconazole
C. Fluconazole or echinocandin
D. Echinocandin (Preferred), Fluconazole (alternative)
E. Echinocandin (Preferred), Amphotericin B, Fluconzole (alternative)
F. Echinocadins or Amphotericin B
G. Voriconazole (Preferred), liposomal amphotericin B, isavuconazonium
H. Amphotericin B + flucytosine (5-fC)
I. Fluconazole (prolonged)
K. Fluconazole, itraconazole or amphotericin B
L. Liposomal amphotericin B followed by itaconazole
M. Amphotericin B +- posaconazole, isavuconazonium
N. Itraconazole, terbinafine, or fluconazole
D. Echinocandin (Preferred), Fluconazole (alternative)
Which of the following is used for the treatment of a blood stream infection in a patient that is neutropenic?
A. Clotrimazole, nystatin
B. PO Fluconazole
C. Fluconazole or echinocandin
D. Echinocandin (Preferred), Fluconazole (alternative)
E. Echinocandin (Preferred), Amphotericin B, Fluconzole (alternative)
F. Echinocadins or Amphotericin B
G. Voriconazole (Preferred), liposomal amphotericin B, isavuconazonium
H. Amphotericin B + flucytosine (5-fC)
I. Fluconazole (prolonged)
K. Fluconazole, itraconazole or amphotericin B
L. Liposomal amphotericin B followed by itaconazole
M. Amphotericin B +- posaconazole, isavuconazonium
N. Itraconazole, terbinafine, or fluconazole
E. Echinocandin (Preferred), Amphotericin B, Fluconzole (alternative)
Which of the following is used for the treatment of Candida glabrata or Candida krusei?
A. Clotrimazole, nystatin
B. PO Fluconazole
C. Fluconazole or echinocandin
D. Echinocandin (Preferred), Fluconazole (alternative)
E. Echinocandin (Preferred), Amphotericin B, Fluconzole (alternative)
F. Echinocadins or Amphotericin B
G. Voriconazole (Preferred), liposomal amphotericin B, isavuconazonium
H. Amphotericin B + flucytosine (5-fC)
I. Fluconazole (prolonged)
K. Fluconazole, itraconazole or amphotericin B
L. Liposomal amphotericin B followed by itaconazole
M. Amphotericin B +- posaconazole, isavuconazonium
N. Itraconazole, terbinafine, or fluconazole
F. Echinocadins or Amphotericin B
Which of the following is used for the treatment of Cryptococcus neofomans (meningitis)?
A. Clotrimazole, nystatin
B. PO Fluconazole
C. Fluconazole or echinocandin
D. Echinocandin (Preferred), Fluconazole (alternative)
E. Echinocandin (Preferred), Amphotericin B, Fluconzole (alternative)
F. Echinocadins or Amphotericin B
G. Voriconazole (Preferred), liposomal amphotericin B, isavuconazonium
H. Amphotericin B + flucytosine (5-fC)
I. Fluconazole (prolonged)
K. Fluconazole, itraconazole or amphotericin B
L. Liposomal amphotericin B followed by itaconazole
M. Amphotericin B +- posaconazole, isavuconazonium
N. Itraconazole, terbinafine, or fluconazole
H. Amphotericin B + flucytosine (5-fC)
For induction
I. Fluconazole (prolonged) –> Consolidation
Which of the following is used for the treatment of Coccidioides immitis?
A. Clotrimazole, nystatin
B. PO Fluconazole
C. Fluconazole or echinocandin
D. Echinocandin (Preferred), Fluconazole (alternative)
E. Echinocandin (Preferred), Amphotericin B, Fluconzole (alternative)
F. Echinocadins or Amphotericin B
G. Voriconazole (Preferred), liposomal amphotericin B, isavuconazonium
H. Amphotericin B + flucytosine (5-fC)
I. Fluconazole (prolonged)
K. Fluconazole, itraconazole or amphotericin B
L. Liposomal amphotericin B followed by itaconazole
M. Amphotericin B +- posaconazole, isavuconazonium
N. Itraconazole, terbinafine, or fluconazole
K. Fluconazole, itraconazole or amphotericin B
What is the treatment dose of Oseltamivir (Tamiflu)?
A. 75 mg daily for 5 days
B. 75 mg BID for 5 days
C. 75 mg daily for 10 days
D. 75 mg BID for 10 days
B. 75 mg BID for 5 days
What is the Prophylaxis dose of Oseltamivir (Tamiflu)?
A. 75 mg daily for 5 days
B. 75 mg BID for 5 days
C. 75 mg daily for 10 days
D. 75 mg BID for 10 days
C. 75 mg daily for 10 days
Match the following brand and generic medications
Rimantadine Acyclovir Valacyclovir Famciclovir Ganciclovir ValGANciclovir Foscarnet -------------------------------- Cytovene Zovirax Valtrex Valcyte Famvir Foscavir Flumantadine
Rimantadine -- Flumantadine Acyclovir -- Zovirax Valacyclovir -- Valtrex Famciclovir -- Famvir Ganciclovir -- Cytovene ValGANciclovir -- Valcyte Foscarnet -- Foscavir
Which of the following are used for Genital Herpes simplex virus?
A. Acyclovir B. Famciclovir C. Famvir D. Ganciclovir E. Foscarnet F. Foscavir G.Cytovene H. Valacyclovir I. Valganciclovir J. Valcyte K. Valtrex M. Zovirax
A. Acyclovir B. Famciclovir C. Famvir H. Valacyclovir M. Zovirax
Which of the following is used for Herpes Zoster (Shingles) treatment
A. Acyclovir B. Famciclovir C. Famvir D. Ganciclovir E. Foscarnet F. Foscavir G.Cytovene H. Valacyclovir I. Valganciclovir J. Valcyte K. Valtrex M. Zovirax
A. Acyclovir
B. Famciclovir
C. Famvir
H. Valacyclovir
M. Zovirax
Which of the following is used to treat Cytomegalovirus (CMV)?
A. Acyclovir B. Famciclovir C. Famvir D. Ganciclovir E. Foscarnet F. Foscavir G.Cytovene H. Valacyclovir I. Valganciclovir J. Valcyte K. Valtrex M. Zovirax
D. Ganciclovir
E. Foscarnet
F. Foscavir
G.Cytovene
I. Valganciclovir
J. Valcyte