Antifungals and Antivirals Flashcards
Which of the following works by binding to ergosterol, altering cell membrane permeability and causing cell death?
A. Nystatin B. Azole Antifungals C. Clotrimazole D. Flucytsoine E. Echinocandins F. Amphotericin B G. Griseofulvin
F. Amphotericin B
Which of the following works by penetrating fungal cells and interfering with fungal RNA and protein synthesis?
A. Nystatin B. Azole Antifungals C. Clotrimazole D. Flucytsoine E. Echinocandins F. Amphotericin B G. Griseofulvin
D. Flucytsoine it is converted to Fluorouracil 5-FU in the cell.
Which of the Following work by decreasing ergosterol synthesis and inhibit cell membrane formation?
A. Nystatin B. Azole Antifungals C. Clotrimazole D. Flucytsoine E. Echinocandins F. Amphotericin B G. Griseofulvin
B. Azole Antifungals
Which of the following work by inhibiting Beta 1,3 D glucan?
A. Nystatin B. Azole Antifungals C. Clotrimazole D. Flucytsoine E. Echinocandins F. Amphotericin B G. Griseofulvin
E. Echinocandins
Which of the Following work by decreasing ergosterol synthesis and inhibit cell membrane formation?
A. Nystatin B. Ketoconazole C. Clotrimazole D. Flucytsoine E. Fluconazole F. Amphotericin B G. Griseofulvin H. Caspofungin I. Voriconacole J. Isavuconazonium K. Micafungin L. Anidulafungin M. Posaconazole N. Itraconazole
Azole Anti fungals
B. Ketoconazole
E. Fluconazole
I. Voriconacole
J. Isavuconazonium
M. Posaconazole
N. Itraconazole
Which of the following work by inhibiting Beta 1,3 D glucan?
A. Nystatin B. Ketoconazole C. Clotrimazole D. Flucytsoine E. Fluconazole F. Amphotericin B G. Griseofulvin H. Caspofungin I. Voriconacole J. Isavuconazonium K. Micafungin L. Anidulafungin M. Posaconazole N. Itraconazole
Echinocandins
H. Caspofungin
K. Micafungin
L. Anidulafungin
Match the following Generics with the Brands
Anidulafungin Ketoconazole Caspofungin Fluconazole Isavuconazonium Itraconazole Micafungin Posaconazole Voriconazole ---------------------------------- Nizoral Diflucan Ketodan Xolegel Sporanox Vfed Noxafil Cresemba Cancidas Mycamine Eraxis
Anidulafungin -- Eraxis Ketoconazole -- Nizoral, Ketodan, Xolegel (all brands are topicals) Caspofungin -- Cancidas Fluconazole -- Diflucan Isavuconazonium -- Cresemba Itraconazole -- Sporanox Micafungin -- Mycamine Posaconazole -- Noxafil Voriconazole -- Vfed
Which class of medications is ONLY available as IV?
A. Azoles
B. Amphotericin B
C. Flucytosine
D. Echinocandins
D. Echinocandins
Which Azole Does NOT cause QT prolongation?
A. Ketoconazole B. Fluconazole C. Itraconazole D. Voriconazole E. Posaconazole F. Isavuconazonium G. Ketodan H. Diflucan I. Vfend J. Cresemba K. Noxafil
F. Isavuconazonium = Cresemba
J. Cresemba
Which is the Only Azole that requires renal dose adjustment?
A. Ketoconazole B. Fluconazole C. Itraconazole D. Voriconazole E. Posaconazole F. Isavuconazonium G. Ketodan H. Diflucan I. Vfend J. Cresemba K. Noxafil
B. Fluconazole = Diflucan
H. Diflucan
CrCl < 50 reduce the dose by 50%
Which of the following is the Drug of Choice for Aspergillus?
A. Ketoconazole B. Fluconazole C. Itraconazole D. Voriconazole E. Posaconazole F. Isavuconazonium G. Ketodan H. Diflucan I. Vfend J. Cresemba K. Noxafil
D. Voriconazole = Vfend
I. Vfend
Which of the following is useful for vaginal candidiasis in non pregnant patients?
A. Ketoconazole B. Fluconazole C. Itraconazole D. Voriconazole E. Posaconazole F. Isavuconazonium G. Ketodan H. Diflucan I. Vfend J. Cresemba K. Noxafil
B. Fluconazole
H. Diflucan
Which of the following do you need to monitor for visual changes and phototoxicity?
A. Ketoconazole B. Fluconazole C. Itraconazole D. Voriconazole E. Posaconazole F. Isavuconazonium G. Ketodan H. Diflucan I. Vfend J. Cresemba K. Noxafil
D. Voriconazole
I. Vfend
Which of the is active against molds including Aspergillus and zygomycetes?
A. Ketoconazole B. Fluconazole C. Itraconazole D. Voriconazole E. Posaconazole F. Isavuconazonium G. Ketodan H. Diflucan I. Vfend J. Cresemba K. Noxafil
E. Posaconazole = Noxafil
K. Noxafil
Which of the medications suspension has less bioavailability then its tablet dose?
A. Ketoconazole B. Fluconazole C. Itraconazole D. Voriconazole E. Posaconazole F. Isavuconazonium G. Ketodan H. Diflucan I. Vfend J. Cresemba K. Noxafil
E. Posaconazole
K. Noxafil