Pharmacogenomics

Question 1

What is pharmacogenomics?

Answer 1

study of how to predict a patients response to a drug based on their genes. It relates single nucleotide polymorphysims with efficacy or toxicity

Question 2

ziagen (Brand)

Answer 2

abacavir

Question 3

epzicom (brand)

Answer 3

Abacavir and lamivudine (epzicom)

Question 4

trizivir

Answer 4

abacavir + zidovudine + lamivudine

Question 5

what is the test for abacavir? what does it test for?

Answer 5

HLA-B*5701 testing for hypersensitivity to ABC. Do not use if +

Question 6

what are sx of abc hypersensitivity reaction?

Answer 6

fever
rash
GI sx
Generalized malaise/fatigue/ achi
SOB, cough, or pharyngitis
IF 2 or more sx STOP!

Question 7

test for clopidogrel?

Answer 7

CYP219 genyotype. Poor metabolizers vs high metabolizers. Poor: dont make much of the active compound so they are gonna have CV events. Use another alternative

Question 8

test for carbamezapmine?

Answer 8

HLA-B 1502 if asian ancestry. puts pts at rid for skin reactions ust as SJS and toxic epidermal necrolysis

Question 9

carbamazepine brand

Answer 9

tegretol

Question 10

traztuzumab

Answer 10

Herceptin (brandt)

Question 11

herceptin (brand)

Answer 11

trastuzumab

Question 12

test for trastuzumab?

Answer 12

test for HER2 /neu oncogene. 2+ or 3+ required

Question 13

which antiHIV med requires tropism testing

Answer 13

Maraviroc or Selzentry

Question 14

which test is done for rituximab?

Answer 14

CD-20 receptor status: because malignant cells express this so its needed for efficacy of medicaitons

Question 15

pharmacogenomic implications of pheytoin?

Answer 15

test for HLAB1502 if asian ancestry. Increases riks fo SJS and TEN if postive . AVOID

Question 16

pharmacogenomic implications of allopurinola?

Answer 16

inc risk of SJS after a skin rash. Could lead to exfoliative, urticarial and purpuric lesions. HLA B5801 allele. D/c at first sight of a rash

Question 17

pharmacogenomic implications of codeine?

Answer 17

extensive CYP2D6 metabolizers increase risk of being affected by converting more codeine to morphine

Question 18

pharmacogenomic implications of warfarin?

Answer 18

cyp2c9 genotypes certain ones would require more INR monitoring

Question 19

which isomer of warfarin is stronger and which one and is metabolized by CYp 2c(

Answer 19

S isomer