Pharmacogenomics

Question 1

Pharmacogenomics: Study of _____ influence on ________, often using _________ data

Answer 1

genomic

drug response

high-throughput

Question 2

Pharmacogenomics high thoroughput data uses COMPLEX interactions such as _______,_______,_______,_______

Answer 2

sequencing, SNP chip, expression, proteomics

Question 3

Pharmacogenetics: Study of __________, usually ________________ on a drug
response

Answer 3

individual gene-drug interactions

one or two genes that have dominant effect

Question 4

Pharmacogenetics uses complex or simple relationship ?

Answer 4

SIMPLE relationship

Question 5

The Human Genome Project (HGP)

Was a _______________ program whose goal was the ___________________

Answer 5

Collaborative research

complete mapping and understanding of all the genes of human beings

Question 6

The Human Genome Project (HGP)

Project started in _____

Project completed in _____

Revealed about _______ human genes

Answer 6

1984

2003

20,500

Question 7

Typical Pharmacogenetic Traits

Insufficient _________ leads to slow inactivation of isoniazid , dapsone

And is seen in more (caucasians or Africans?)

Answer 7

N-acetylase transferase (NAT 2)

Caucasians

Question 8

Typical Pharmacogenetic Traits

Insufficient __________ leads to Prolonged respiratory paralysis on exposure to suxamethonium

Found in 1 in _______ ———-

Answer 8

Serum Pseudocholinesterase

2000

Caucasians

Question 9

Typical Pharmacogenetic Traits

Insufficient ____________ leads to Hemolysis (anemia) from antimalarials

Found in 1 in 100 _____

Answer 9

Glucose 6 Phosphate Dehydrogenase (G6PD) 

African Americans

Question 10

Typical Pharmacogenetic Traits

Insufficient __________ levels leads to Bone marrow toxicity from thiopurine, mercaptopurine

Answer 10

Thiopurine methyl transferase (TPMT)

Question 11

CYP families in humans

Humans have _______ genes
Divided among ____ families of cytochrome P450

Answer 11

57

18

Question 12

CYP450 family

______,____,____,_____,_____,____, and _____ are responsible for metabolizing most
clinically important drugs

Answer 12

CYP2A6, CYP2B6, CYP2C9 ,CYP2C19, CYP2D6, CYP2E1 and CYP3A4

Question 13

Which CYP enzymes work on caffeine

Answer 13

1A1
1A2
2E1
3A4

Question 14

Which CYP enzymes work on acetaminophen

Answer 14

1A2
2C
2E1
2D6
3A4

Question 15

Which CYP enzymes work on warfarin

Answer 15

1A1
1A2
2C
3A4

Question 16

Which CYP enzymes work on cyclophosphamide

Answer 16

2B6
3A4

Question 17

Which CYP enzymes work on testosterone

Answer 17

1A1
2A6
2C
3A4

Question 18

Thiotepa

Inducer or inhibitor

Answer 18

Inhibitor

Question 19

Fluoxetine

Inducer or inhibitor

Answer 19

Inhibitor

Question 20

Paroxetine

Inducer or inhibitor

Answer 20

Inhibitor

Question 21

Disulphiram

Inducer or inhibitor

Answer 21

Inhibitor

Question 22

Ethanol

Inducer or inhibitor

Answer 22

Inducer

Question 23

Dexamethasone

Inducer or inhibitor

Answer 23

Inducer

Question 24

Glucocorticoid

Inducer or inhibitor

Answer 24

Inducer

Question 25

Prednisone Inducer or inhibitor

Answer 25

Inducer

Question 26

Tobacco smoke Inducer or inhibitor

Answer 26

Inducer

Question 27

Phenobarbital Inducer or inhibitor

Answer 27

Inducer

Question 28

Tricyclic antidepressants decrease ________ and a consequent (rise or fall?) in ______ levels in cleft

Answer 28

serotonin reuptake Rise serotonin

Question 29

Selections of antidepressant drugs are largely based on _______

Answer 29

trial and error

Question 30

Response rates of antidepressants are (low or high?) , with less than one- third of patients achieving adequate response after 4 to 6 weeks of treatment

Answer 30

Low

Question 31

CYP_____ is the most investigated CYP enzyme with regards to antidepressant pharmacogenomics

Answer 31

2D6

Question 32

Codeine it must be metabolized into _____ for activity

Answer 32

morphine

Question 33

codeine is an active drug T/F

Answer 33

F codeine is a prodrug

Question 34

Codeine Cytochrome P450 allele _______ is the metabolizing enzyme in the liver

Answer 34

CYP2D6

Question 35

7% of (Africans or Caucasians?) are defficient in CYP2D6 gene codeine does not work effectively in these individuals T/F

Answer 35

Caucasians T

Question 36

Tamoxifen Active or inactive

Answer 36

Inactive

Question 37

Tamoxifen Needs to be converted to ______ to be active Catalyzed by _______

Answer 37

endoxifen CYP2D6

Question 38

Limitations of pharmacogenomics The _______ and ______ to Genomic Technologies Concerns about the ________ of _______

Answer 38

Cost Factor and Access confidentiality of genetic information

Question 39

Limitations of pharmacogenomics Concerns about the confidentiality of genetic information Employer could ____________________ ____________________ company

Answer 39

get the results of a genetic test that showed whether you are more likely to get sick in the future Health insurance