Pharmacogenetics

Question 1

1. How a drug elicits responses, whether the responses are
   desirable or undesirable, is described by which one of the
   following?

a. Pharmacodynamics
b. Phenocopying
c. Pharmacokinetics
d. Pharmacogenetics
e. Pharmacogenomics

Answer 1

a. Pharmacodynamics

Question 2

2. A drug that is administered in an inactive form that must
   be metabolized to an active form is referred to as a(n)

a. Cytochrome P450 (CYP450) enzyme
b. Antimetabolite
c. Prodrug
d. Poor metabolizer
e. Drug metabolite

Answer 2

c. Prodrug

Question 3

3. Which of the following is an active drug that gets inactivated by metabolism?

a. Clopidogrel
b. Codeine
c. Tamoxifen
d. Warfarin
e. Irinotecan

Answer 3

d. Warfarin

Question 4

4. What is the drug-metabolizing phenotype when an individual has two nonfunctional alleles?

a. Extensive/normal metabolizer
b. Intermediate metabolizer
c. Rapid metabolizer
d. Poor metabolizer
e. Ultrarapid metabolizer

Answer 4

d. Poor metabolizer

Question 5

5. What characterizes a type A adverse drug reaction?

a. It is caused by the drug’s pharmacological effects
b. It is independent of dose
c. It is an unexpected effect
d. The drug class can never be given again
e. It can be caused by the immune system

Answer 5

a. It is caused by the drug’s pharmacological effects

Question 6

6. A pathologic disorder linked to the ingestion of fava beans,
   commonly described as favism, is caused by an enzyme
   deficiency that also has pharmacogenetic implications.
   Which gene is involved?

a. CFTR
b. TPMT
c. G6PD
d. NAT2
e. CYP2C19

Answer 6

c. G6PD