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UROGENITAL > [PHARMA] PROSTATIC DISEASES > Flashcards

[PHARMA] PROSTATIC DISEASES Flashcards

1
Q

drugs reducing dynamic factors (4)

A

1-Tamsulosin
2-Tadalafil
3-Tolterodine
4-Mirabegron

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2
Q

drugs reducing static factors (6)

A

finasteride
2-gonadorelin
3-leuprolide
4-abiraterone
5-degarelix
6-enzulatamide

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3
Q

tamsulosin mechanism of action

A

(-) α1 receptor of smooth msc–>smooth msc relaxation–>↓bladder obstruction

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4
Q

advantage of tamsulosin (4)

A

1-improve voiding symptoms
2-improve storage symptoms
3-doesn’t change prostate size (in transitional zone)
4-doesn’t affect libido

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5
Q

side effects of tamsulosin (2)

A

1-orthostatic HypoTN w dizzines
2-retrograde ejaculation

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6
Q

dosage of tadalafil

A

5mg

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7
Q

alpha 1 blocker

A

tamsulosin

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8
Q

PDE5 inhibitor

A

tadalafil

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9
Q

tadalafil & sildenafil mechanism of action

A

improve LUTs by:
(-) PDE5 in c. cavernosa
(-) cGMP metabolism
↑CGMP through NO pathway
maintain VD

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10
Q

used in sexually active LUTS-BPH patients with or without ED

A

tadalafil

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11
Q

uses of tadalafil (3)

A

1-ED
2-pulmonary HTN
3-sexually active LUTS-BPH patients +/_ ED

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12
Q

drug used in pulmonary HTN

A

tadalafil

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13
Q

side effects of tadalafil (5)

A

1-VD & Hypotension
2-flushing, headache, nasal congestion
3-affect contractility
4-visual disturbances
5-back pain

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14
Q

visual disturbances caused by tadalafil due to

A

(-) PDE6 in retina= loss of discrimination b/w green & blue

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15
Q

contractility dysfunction caused by tadalafil due to

A

(-) PDE1 in ventricular muscle

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16
Q

contraindications of tadalafil (2)

A

1-with nitrates & alpha blockers
2-cardiac patients

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17
Q

sildenafil & tadalafil route of administration

A

orally

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18
Q

1st choice in young patients with erectile dysfunction

A

sildenafil & tadalafil

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19
Q

hypotension with sildenafil & tadalafil can be avoided by

A

starting w/ small dose & titration

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20
Q

M3 blocker

A

tolterodine

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21
Q

tolterodine mechanism of action

A

(-) M3 in bladder smooth msc–> ↓bladder contraction

22
Q

advantage of tolterodine (3)

A

improve LUTS
improve nocturia
help treat overactive bladder

23
Q

overactive bladder TTT

A

tolterodine

24
Q

tolterodine side effects

A

1-atropine like effects; dry mouth, tremors, tachycardia,coma etc (MC)
2-acute urinary retention (Most serious)

25
causes detrusor flaccidity
tolterodine
26
treat nocturia
tolterodine
27
most serious side effect of tolterodine
acute urinary retention
28
selective B3 agonist
Mirabegron
29
mirabegrone side effects (5)
1-headache 2-HTN 3-constipation 4-nasopharyngitis 5-UTI
30
interval b/w nitrates intake & tadalafil should be
At least 48h
31
_____affect efficacy of tadalafil
diuretics
32
finasteride mechanism of action
(-)5-α reductase ↓conversion of testosterone to DHT ↓DHT =shrink enlarged prostate + prevent progression
33
finasteride side effects (4)
1-impotence 2-decreased libido 3-decreased ejaculate volume 4-gynecomastia
34
GnRH analogs
Gonadorelin Leuprolide
35
GnRH analogs mechanism of action
(-) gonadotropins release
36
GnRH analogs uses (3)
1-cancer prostate 2-endometriosis 3-IVF
37
GnRH side effects in males & females
1-headaches 2-depression 3-osteoporosis 4- ↓libido
38
GnRH side effects in females
1-hot flushes 2-vaginal dryness 3-ovarian cyst
39
phototherapy effects on BPH
1- (-) 5-α reductase 2-anti-inflammatory 3-free radical scavenger 4-protect prostate & detrusor function 5-antiandrogenic (-) sex hormone binding globulin (SHBG) & aromatase
40
inhibits SHGB
phototherapy
41
(-) aromatase
Finasteride phototherapy
42
TTT of hormone sensitive prostate cancer
androgen deprivation
43
LRH analogue disadvantage
initial stimulation of androgen release
44
Abiraterone route of administration
oral
45
Abiraterone mechanism of action
(-) androgen synthesis by testis & adrenals
46
Abiraterone side effects (3)
1-hypertriglyceridemic 2-hyperglycemic 3-↑ liver function enzymes
47
Degarelix mechanism of action
irreversible inhibitor of GnRH receptor (-) gonadotropins
48
advantage of Degarelix over LHRH analogues
no initial stimulation of androgen release
49
enzalutamide route of administration
oral
50
enzalutamide mechanism of action
(-) androgen binding to its receptor affects nuclear translocation of androgen receptors

UROGENITAL (22 decks)

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