[PHARMA] ERECTILE DYSFUNCTION Flashcards
Risk factors of ED (4)
1-DM
2-hyperlipidemia
3-HTN
4-anxiety
drugs causing ED (7)
1- antihypertensives
2-antidepressants
3-antipsychotics
4-lipid lowering drugs (statin)
5-antiandrogen
6-narcotics
7-H2 blockers
1ry goal of therapy
achievement + maintenance of erection
improvement quality of life
ideal ED therapy
1-minimal side effects
2-quick onset
3- few or no drug interactions
non pharmacological TTT of ED (7)
1-exercise
2-weight loss
3-smoking cessation
4-stop drugs
5-psychotherapy
6-vacuum erection devices
7-prostheses
PDE5 inhibitors
sildenafil
tadalafil
sildenafil & tadalafil mechanism of action
(-) PDE5 in cavernousal body
(-) cGMP metabolism
↑cGMP
maintain VD
sildenafil & tadalafil route of administration
oral
1st choice in young patients with ED
sildenafil & tadalafil
to prevent hypotension with sildenafil & tadalafil usage:
start w/ small dose + gradually titrate
sildenafil & tadalafil use
1-ED
2-pulmonary HTN
sildenafil & tadalafil side effects (4)
1-VD, hypoTN
2-flushing, headaches, nasal congestion, back pain
3-affect contractility
4-visual disturbance
visual disturbance w/ sildenafil & tadalafil is due to
(-) PDE6 in retina= loss of discrimination b/w green & blue
sildenafil & tadalafil contraindications
1-with nitrates & α blockers
2-cardiac patients
PGE1 analog
alprostadil
alprostadil mechanism of action
(+) adenyl cyclase= ↑cAMP= smooth msc relaxation of BV