Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

UROGENITAL > [PHARMA] CONTRACEPTION & FERTILITY > Flashcards

[PHARMA] CONTRACEPTION & FERTILITY Flashcards

1
Q

ethinyl estradiol
diethyl stilbosterol side effects(4)

A

1-nausea, breast tenderness, weight gain
2-endometrial hyperplasia
↑endo & breast cancer risk
3-HTN & thromboembolism
4-male= feminization, impotence, decreased libido, gynecomastia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

adv effects of ethinyl estradiol & diethyl stilbosterol in MALES (4)

A

1-impotence
2-decreased libido
3-feminization
4-gynecomastia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Synthetic estrogens

A

ethinyl estradiol
diethyl stilbosterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

synthetic estrogens uses (2)

A

1-OC
2-HRT in
(a) 1ry hypogonadism
(b) postmenopause

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

effects of synthetic estrogens during the postmenopausal period (3)

A

1- ↓osteoporosis
2-↓menopausal symptoms
3- Cardioprotective: ↓LDL ↑HDL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

synthetic progestins(3)

A

1-norethindrone
2-norgestrel
3-medroxyprogesterone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

synthetic progestins uses (3)

A

1-hormonal contraception
2-dysmenorrhea
3-endometriosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

synthetic progestins adv effects (5)

A

1-irregular bleeding followed by amenorrhea
2-edema, HTN, weight gain
3-depression
4-↓HDL
5-acne, hirustism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ovulation inducing agents (5)

A

1-clomiphene
2-bromocriptine
3-gonadorelin
4-hCG
5-human menopausal gonadotropins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

ergot alkaloids (2)

A

1-methylergometrine
2-methylergonovine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

methylergometrine & methylergonovine advantages (3)

A

1-potent
2-prolonged sustained uterine contractions
3-less toxic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

methylergometrine & methylergonovine CI

A

delivery inducers= fetal distress & mortality

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

DOC in postpartum Hg

A

ergot alkaloids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

ergot alkaloids mechanism of action

A

mixed partial agonists at α adrenoreceptors & 5HT receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

ergot alkaloids route

A

-oral
-parenteral IM
-intramyometrial

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

why are ergots not given IV

A

cause severe VC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

ergot alkaloids uses (3)

A

1-postpartum Hg
2-after C-section & instrumental surgery= prevent uterine atony
3-subinvolution of uterus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

ergots CI (3)

A

1-pregnancy
2-HTN patients
3-coronary artery disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

ergots adv effects (6)

A

1-vasospasm
2-palpitations
3-↑ BP
4-seizures
5-abdominal pain, nausea, vomiting
6-↓milk production w/ prolonged usage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

oral contraceptives mechanism of action

A

1-(-) FSH & LH= (-) ovulation
2- change cervical mucous= thick & viscid
3-↓ endometrial glycogen= inhibits implanatation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

combined OCs

A

most effective estrog+progest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

minipills

A

progestin only
less reliable but no risk of thromoboembolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

parenteral progestin preparations

A

1-implants norgesterel—> 5 years
2-depot injection: medroxyprogesterone–> every 3 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

OCs indication

A

contraception
irregular cycle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
minor risks of OCs (3)
1-nausea, vomiting, headache 2-breast tenderness 3-edema
26
intermediate risks of OCs (3)
1-bleeding (low dose) 2-amenorrhea (high dose) 3-acne, hirstusim, skin pigmentation
27
major risks of OCS (4)
1-CVS= thromboembolism, pulmonary embolism, MI, stroke, HTN 2-carcinogenic= ↑ breast & endo cancer 3-depression 4-cholecystitis, jaundice, gall stones
28
drug interactions of OCs
enzyme inducers: rifampcin ↓ efficacy of OC
29
increased risk of cervical & breast cancer caused by OCs can be ↓ by
adding progestins
30
clomiphene mechanism of action
partial agonist (-) central estrogen receptors in hypothalamus (-) feedback inhibition of FSHRH & LHRH (+) ovulation & corpus luteum formation
31
clomiphene route
oral
32
clomiphene uses (2)
1-female infertility (ovulation disorders) 2-IVF w/ gonadotropins
33
IVF drugs (3)
1-clomiphene 2-GnRH 3-hCG
34
clomiphene adv effects (3)
1-hot flushes 2-multiple pregnancies 3-ovary overstimulation
35
tamoxifen uses
TTT of hormone-sensitive breast cancer
36
tamoxifen mechanism of action
selective estrogen receptor modulator (SERM) peripherally **ANTAGONIST**--> Breast= (-) endogenous estrogen from activating receptors in estrogen sensitive cancer **AGONIST**--> bone= increase density (-)osteoporosis in pt w/ breast cancer uterus=↑ endo cancer risk
37
tamoxifen adv effects (3)
1-hot flushes 2-vaginal discharge 3-menstrual irregularity
38
raloxifen mechanism of action
SERM partial agonist similar to estrogen on bone but NOT ON breast/uterus= no cancer risk
39
raloxifen uses
TTT of osteoporosis
40
drug causing ovary overstimulation
clomiphene
41
drugs reducing milk production
ergot alkaloids
42
acts centrally
clomiphene
43
acts peripherally
tamoxifen
44
treats osteoporosis
raloxifen
45
↑ risk of endometrial cancer
1-synthetic estrogens 2-tamoxifen
46
↑risk of cervical & breast cancer
combined OC
47
decrease risk of breast cancer
tamoxifen
48
used to induce abortion in case of intrauterine fetal death
mifepristone
49
raloxifene side effects
1-hot flushes, sweating 2-leg spasms
50
raloxifene CI
venous thromboembolism
51
combined OC CI
liver disease
52
contraindicated in coronary artery disease
ergots
53
contraindicated in venous thromboembolism
raloxifene
54
contraindicated in pregnancy & HTN patients
ergots
55
antiprogestin
mifepristone
56
mifepristone mechanism of action
competitive inhibitor of progesterone & glucocorticoids receptors
57
mifepristone use
therapeutic abortion
58
GnRH
1-gonadorelin 2-leuprolide 3-nafarelin
59
use of GnRH given in pulses
infertility= ↑gonadotropins= (+) ovulation
60
use of GnRH given continuously (3)
↓ gonadotropins: 1-cancer prostate 2-endometriosis 3-IVF
61
GnRH adv effects (3)
1-hot flushes, headache, depression 2-vaginal dryness, ovarian cyst, ↓libido 3-osteoporosis
62
GnRH anatogonist
ganirelix
63
ganirelix uses
1-controlled ovarian hyperstimulation ( inhibit LH surge) 2-advanced prostatic cancer
64
gonadotropins FSH, LH uses
1-(+) spermatogenesis + testosterone 2-(+) ovulation & ER/PR
65
drugs used in prostatic cancer
GnRH ganirelix
66
hMG (3)
menotropins (FSH+LH) urofollitropin (FSH) follitropin r-FSH
67
hcG similar to
LH
68
hcG uses (3)
1-infertility-->IVF 2-undescended testis 3-1ry or 2ry amenorrhea dt ↓gonadotropins
69
gonadotropins adv effects (4)
1-hyperstimulation $ 2-multiple births 3-spontaneous abortions 4-gynecomastia in males
70
pulsatile GnRH route
SC
71
hcG route
parenteral

UROGENITAL (22 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions