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Test 7 > Pharm 7 Anti-Parkinsons > Flashcards

Pharm 7 Anti-Parkinsons Flashcards

1
Q

Amount of neurons lost needed for for Parkinson’s symptoms

A

60%

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2
Q

Parkinson’s effect on STN

A

Increased activation of STN

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3
Q

-Reserpine-

A

Deplete dopamine

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4
Q

Brain area of Dopamine depletion

A

Striatum (Putamen, Globus Pallidus)

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5
Q

-Carbidopa-

A

Inhibit peripheral decarboxylation of DA

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6
Q

L-Dopa side effects

A

“on-off” freezing
Peak dose grimacing & dyskinesia
Behavioral SE
Dementia

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7
Q

-Bromocriptine-
Indication
MOA

A

L-DOPA adjunct

D2 agonist, D1 antagonist

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8
Q

-Bromocriptine-

Metabolism

A

Liver

4-6h half life (short)

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9
Q

-Pergolide-
MOA
SE

A

D1 and D2 agonist

Heart valve regurgitation (withdrawn)

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10
Q

-Pramipexole-
Indication
MOA

A

Early mono-therapy
Also L-DOPA adjunct (reduce on-off effects)

D2 agonist

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11
Q

-Pramipexole-

Metabolism

A

Kidney

8-14h half life

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12
Q

-Ropinirole-
Indication
MOA

A

Early mono-therapy
L-DOPA adjunct

D2 agonist

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13
Q

-Ropinirole-

Metabolism

A

Liver

3-4h half life (short)

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14
Q

-Selegiline-
Indication
MOA

A

Early mono-therapy
L-DOPA adjunct
Improve cognitive functions

MAO-B inhibitor

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15
Q

-Selegiline-

Metabolism

A

Liver

1.5h half life (short)

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16
Q

-Selegiline-

Contraindications

A

TCA
SRI
(Serotonin syndrome)

17
Q

-Tolcapone-
Indication
MOA

A

Late adjunct

Inhibit CNS & peripheral COMT

18
Q

-Entacapone-
Indication
MOA

A

Late adjunct

Inhibit peripheral COMT

19
Q

COMT inhibitor main use

A

Patients that develop “freezing”

Ameliorate peak dose dyskinesia

20
Q

-Amantadine-
Indication
MOA

A

Early onset PD, heavy bradykinesia

Enhance DA levels
Anticholinergic
Anti-viral
NMDA antagonist

21
Q

Drug eliciting orthostatic hypotension & cardiac arrhythmia SE

A

Bromocriptine

22
Q

Drugs contraindicated with HTN

A

MAO B inhibitors

23
Q

PD surgery

A

Deep Brain Stimulation of STN

24
Q

Huntington’s chorea Tx

A

Reserpine

25
Q

Tourette’s Tx

A

Neuroleptics (Haloperidol or pimozide)
Alpha 2a Agonists (Clonidine or guanfacine)
SSRIs (Fluoxetine)

26
Q

Benign Essential Tremor Tx

A

Primidone (anti-convulsant)

27
Q

Dystonia Tx

A

Botox

28
Q

ALS Tx

A

Baclofen for spasticity

Test 7 (26 decks)

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