Pharm 12 Drug Abuse

Question 1

Tolerance mechanism

Answer 1

Homeostatic adaptation

Question 2

Tolerance is evidence of

Answer 2

Physical dependence

Question 3

Tolerance does not imply

Answer 3

Addiction

Question 4

DA reward circuit

Answer 4

VTA -> NAc -> Behavior

Question 5

Opioids site of action

Answer 5

MOR -> inhibit GABA interneurons that are inhibiting DA neurons

Question 6

Opioid mixed agonist Tx

Answer 6

-Buprenorphine-

Question 7

Opioid withdrawal Tx

Answer 7

• Methadone- (no euphoria)

- Clonidine- (A2 agonist inhibits LC)

Question 8

Benzodiazepine activation of NAc

Answer 8

Disinhibit DA via inhibiting GABA interneurons

Question 9

Benzodiazepine OD Tx

Answer 9

Flumazenil

Question 10

Long term compensation for stimulant use

Answer 10

Increase in DA excitability

Question 11

Psychostimulant OD Tx

Answer 11

Sedatives

Anti-psychotics (SE - lower seizure threshold)

Question 12

Stimulant vaccine

Answer 12

Cocaine antibodies

Question 13

Nicotine activation of NAc

Answer 13

Excite glutamate neurons via nAChR

Question 14

Psychedelic activation of NAc

Answer 14

Very little

No dependence

Question 15

Hallucinogen MOA

Answer 15

5-HT2A agonist (LSD)

SRI (MDMA)

Question 16

Hallucinogen Tx

Answer 16

Diazepam for bad trip

NOT antipsychotics

Question 17

Dissociative MOA

Answer 17

NMDA glutamate blockade

Question 18

Dissociative Tx

Answer 18

Antipsychotic if MILD
Avoid chlorpromazine (anticholinergic)

Question 19

Cannabinoid activation of NAc

Answer 19

Decrease GABA release from interneuron