Penicillins

Question 1

PCN is bactericidal or bacteriostatic?

Answer 1

bactericidal

Question 2

What is PCNs MOA?

Answer 2

• weakens bacterial cell wall cause influx of water and rupture
• inhibits transpeptidase
• disinhibition (activation) of autolysins

Question 3

What are autolysins?

Answer 3

bacterial enzymes used to cleave bonds in the cell wall to allow for cellular growth and division

Question 4

PCN G (benzylpenicillin) used to treat which organism(s)?

Answer 4

• non-PCNase producing gram positive
• neisseria meningitidis
• non-PCNase producing neisseria gonorrhea
• anaerobes
  -spirochetes
  Treponema pallidum (causative agent for syphillus)

Question 5

PCN cross sensitivity can occur with which drug?

Answer 5

cephalosporins

Question 6

What are the PCN narrow spectrum - PCNase sensitive drugs?

Answer 6

• penicillin G

- penicillin V

Question 7

What are the PCN narrow spectrum - PCNase resistant drugs?

Answer 7

• Nafcillin
• oxacillin
• dicloxacillin

Question 8

What are the PCN broad spectrum drugs?

Answer 8

• ampicillin

- amoxicillin

Question 9

What are the PCN extended spectrum drugs? -

Answer 9

• piperacillin

Question 10

Narrow spectrum - PCNase sensitive PCN drugs are used to treat what organisms?

Answer 10

• streptococcus species
• Neisseria species
• many anaerobes
• spirochetes

Question 11

Narrow spectrum - PCNase resistant PCN drugs are used to treat what organisms?

Answer 11

• Staphylococcus aureus

- Staphylococcus epidermidis

Question 12

PCN broad spectrum drugs are used to treat what organisms?

Answer 12

• haemophilus influenza
• E coli
• proteus mirabilis
• enterococci
• neisseria gonorrhea

Question 13

PCN extended spectrum drugs are used to treat what organisms?

Answer 13

• pseudomonas aeruginosa
• Enterobacter species
• proteus
• Bacteroide’s fragilis
• many klebsiella species

Question 14

Narrow spectrum - PCNase resistant PCN drugs are also known as?

Answer 14

antistaphylococcal PCN

Question 15

PCN extended spectrum drugs are also known as?

Answer 15

antipseudomonal penicillin

Question 16

What are the PCN broad spectrum drugs are also known as?

Answer 16

aminopenicillins

Question 17

What is the treatment of choice against MRSA?

Answer 17

vancomycin

Question 18

What is the drug name for amoxicillin and clavulanic acid combination?

Answer 18

Augmentin

Question 19

What is the drug name for ampicillin and sulbactam combination?

Answer 19

Unasyn

Question 20

Zosyn is a combination of what drugs?

Answer 20

piperacillin and tazobactam

Question 21

What is the action of tazobactam when combined with piperacillin?

Answer 21

inhibits B-lactamase, preventing the inactivation of pipercillin

Question 22

What is the action of sulbactam when combined with ampicillin?

Answer 22

inhibits B-lactamase, preventing the inactivation of ampicillin

Question 23

Unasyn is a combination of what drugs?

Answer 23

ampicillin and sulbactam

Question 24

Augmentin is a combination of what drugs?

Answer 24

amoxicillin and clavulanic acid

Question 25

What is the action of clavulanic acid when combined with amoxicillin?

Answer 25

inhibits B-lactamase, preventing the inactivation of amoxicillin

Question 26

What is the principal target of piperacillin?

Answer 26

pseudomonas aeruginosa

Question 27

Treponema pallidum is what type of bacteria?

Answer 27

spirochete

Question 28

What is the causative organism for syphyllus?

Answer 28

treponema pallidum