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ENRP - Exam 2 > Pediatric Endocrine Disorders > Flashcards

Pediatric Endocrine Disorders Flashcards

1
Q

Precocious Puberty

A

Onset of secondary sex characteristics before 8 in girls and 9 in boys

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2
Q

What defines Precocious Puberty in girls?

A

Progressive breast development

+ crossing percentile lines upward on linear growth chart

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3
Q

What defines Precocious Puberty in boys?

A

Testicular/Penile enlargement

+ crossing percentile lines upward on the liner growth curve

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4
Q

Describe the growth rate seen with Precocious Puberty?

A

Initially fast

–> Overall end height is LESS than normal

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5
Q

With Precocious Puberty how will the Bone Age be?

A

ADVANCED Bone Age

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6
Q

What imaging studies should be acquired with Precocious Puberty?

A

Bone age
MRI of the head
US of gonads

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7
Q

What are 5 serum markers to measure with Precocious Puberty?

A 
LH
FSH
Estradiol
Testosterone
17-hydroxyprogesterone
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8
Q

With Turner Syndrome, what is the most common karyotype? What is the next common option?

A

Non-mosaic = 45XO

– Next common would be 46XX but a short arm on one X is missing

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9
Q

How will those with Turner Syndrome look?

A

Short stature
Webbed neck/excess skin
Wide shield shaped chest
Widely spaced nipples

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10
Q

Describe the sexual development with Turner Syndrome?

A

Gonadal dysgenesis = streak ovaries = Primary Amenorrhea and NO puberty

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11
Q

What 2 conditions is Turner Syndrome associated with?

A

Congenital heart disease

Horseshoe kidney

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12
Q

What is Premature Adrenarche?

A

Development of coarse, dark pubic/axillary hair before 8 in girls and 9 in boys

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13
Q

Development of pubic/axillary hair before 8 in girls and 9 in boys?

A

Premature Adrenarche

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14
Q

Can there be body odor, acne, oily hair with Premature Adrenarche?

A

Yes

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15
Q

Usually is Premature Adrenarche benign or malignant?

A

Benign condition

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16
Q

What commonly causes Premature Adrenarche?

A

Early maturation of Zona Reticularis

17
Q

When the Bone Age assessment is done with Premature Adrenarche, if it is normal or slightly advanced, what is likely the cause?

A

Early maturation of zona reticularis

18
Q

When the Bone Age assessment is done with Premature Adrenarche, if it is > 2 SD from normal or if there are other signs of puberty, what should be worked up?

A

Precocious puberty

19
Q

When the Bone Age assessment is done with Premature Adrenarche, if it shows significant growth acceleration, you need to?

A

Do further workup

20
Q

What is Premature Thelarche?

A

Breast tissue development before 8 in girls

21
Q

When does Premature Thelarche/Adrenarche need further workup?

A
  • Other secondary sex characteristics present
  • Bone Age > 2 SD from normal
  • Significant growth acceleration
22
Q

When does Premature Thelarche/Adrenarche need further workup?

A
  • other secondary sex characteristics present
  • Bone Age > 2 SD from normal
  • significant growth acceleration
23
Q

What can cause congenital hypothyroidism? (2)

A

Absent/Abnormal thyroid gland

Inadequate thyroid hormone production

24
Q

Congenital Hypothyroidism is a common cause of?

A

Intellectual disability

25
Q

Congenital Hypothyroidism can be asymptomatic or symptomatic. What are some symptoms?

A 
Hoarse cry
Coarse facial features
Lethargy and Hypotonia
Constipation
Poor feeding
Jaundice
26
Q

What facial changes are present with Congenital Hypothyroidism?

A

Coarse facial features
Macroglossia
Large Fontanelles

27
Q

Hoarse cry, coarse facial features, lethargy, hypotonia, jaundice, constipation, feeding issues, etc. are associated with?

A

Congenital Hypothyroidism

28
Q

What usually causes Acquired Hypothyroidism?

A

Autoimmune Thyroiditis

29
Q

In addition to the normal Hypothyroidism symptoms, what can be seen in a child that acquired it?

A

Short stature with declining growth velocity
Poor performance in school
Abnormal pubertal development

30
Q

In addition to the normal Hypothyroidism symptoms, what else can be seen in a child that acquired it?

A

Short stature with declining growth velocity
Poor school performance
Abnormal pubertal development

ENRP - Exam 2 (21 decks)

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