Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

ENRP - Exam 2 > Drugs for Thyroid Disorders > Flashcards

Drugs for Thyroid Disorders Flashcards

1
Q

Thyroid Hormones act on the ____ hormone receptor ____

A

Nuclear Hormone Receptor TRalpha/beta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Once T3 binds to the hormone receptor, what occurs?

A

Complex move to the nucleus and begins transcription

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the active form of the Thyroid Hormones?

A

T4 is converted in the peripheral tissues to T3 = Active form

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are 3 drugs that can be used to treat HYPOthyroidism?

A

Levothyroxine (T4)
Liothyronine (T3)
Liotrix (4:1 of T4:T3)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is Levothyroxine?

A

T4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is Liothyronine?

A

T3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is Liotrix?

A

4:1 ratio of T4:T3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How long can the effect of Levothyroxine take to be seen?

A

Up to 6 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

With excessive dosing of Levothyroxine, what adverse effects can be seen?

A

Similar to HYPERthyroidism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are drugs that can impair Levothyroxine absorption?

A
  • CHOLESTRYAMINE

- PPIs, antacids, anti-ulcer meds, iron, etc.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What can Cholestryamine do?

A

Impair the absorption of Levothyroxine to treat Hypothyroidism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What drug is commonly used during a Thyroid Storm/Thyrotoxicosis to decreased HR and tremor?

A

Propranolol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

MOA for Propranolol and when is it commonly used?

A

Non-selective beta blocker

= Used to decrease HR and tremor with Thyroid storm/thyrotoxicosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How does Propanolol specifically treat the Hyperthyroidism?

A

(-) peripheral conversion of T4 to T3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which Thiamide is more potent - PTU or Methimazole?

A

Methimazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the 2 main Thiamides?

A

PTU (propylthiouracil)

Methimazole

17
Q

What is the MOA for Thiamides?

A

Block Iodide organification by preventing the addition of iodine to tryosine residues on Thyroglobulin

18
Q

When should you use caution when treating with Thiamides?

A

Agranulocytosis

Pre-existing liver disease, hepatitis, alcohol use

19
Q

Methimazole can treat Hyperthyroidism by doing what things?

A
  • Preventing addition of iodine to tyrosine residues on thyroglobulin
  • (-) Thyroperoxidase enzyme needed to synthesis T3/T4
20
Q

Besides treating Hyperthyroidism, when else can Methimazole be used?

A

Taken before thyroid surgery to minimize effect of thyroid manipulation

21
Q

When is PTU often used? (3)

A

Graves disease
Toxic Multinodular goiter
Thyroid storm

22
Q

When is PTU often used?

A

Graves disease
Toxic multinodular goiter
Thyroid storm

23
Q

Can PTU inactivate pre-existing T3/T4?

A

NO

24
Q

What does Potassium Iodide treat and how?

A

Hyperthyroidism

= Blocks iodide uptake

25
Q

What can treat Hyperthyroidism by blocking iodide uptake?

A

Potassium Iodide

26
Q

What anti-thyroid drug can be used to protect the thyroid from radiation exposure by shrinking it?

A

Potassium Iodide

27
Q

What can treat Thyroid Cancer?

A

Radioactive Iodine

28
Q

How does Radioactive Iodine treat Thyroid Cancer?

A

Iodine is absorbed into gland

-> Radiation destroys gland

29
Q

When should you NOT use Radioactive Iodine?

A

Pregnant women

30
Q

When should you NOT use Radioactive Iodine?

A

Pregnant women

31
Q

What normal drug can CAUSE type 2 Thyrotoxicosis?

A

Amiodarone

32
Q

What is Amiodarone used for and what can it cause?

A

Treats Arrhythmias

–> Thyrotoxicosis via thyroid tissue destruction

33
Q

What is the daily iodine recommendation?

A

0.15 mg

34
Q

How much free Iodine can Amiodarone release with each tablet?

A

7.4 mg – way too much

35
Q

If a patient is being treated for an arrhythmia and they start to develop signs of hyperthyroidism, what drug are they likely on?

A

Amiodarone

36
Q

Type 1 Thyrotoxicosis occurs in who?

A

Patients with underlying thyroid pathology

37
Q

Type 2 Thyrotoxicosis occurs with what medication and how?

A

Amiodarone

  • -> thyroid tissue destruction/thyroiditis
  • -> excess thyroid hormones released into the circulation

ENRP - Exam 2 (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions