Adrenal Medulla and MEN Syndromes Flashcards
What cells are in the Adrenal Medulla?
Chromaffin cells
What do Chromaffiin cells in the Medulla secrete?
Catecholamines = Epinephrine and Norepinephrine
The Adrenal Medulla is under what control?
Sympathetic control
Stat rule on Pheochromocytomas?
10% rule
– 25% familial
A Pheochromocytoma is found in the medulla. What does it secrete?
Catecholamines
What is a very profound symptom with Pheochromocytomas?
HTN
What is the classic triad seen with Pheochromocytomas?
Headache
Palpitations
Diaphoresis
What is the classic triad seen with Pheochromocytomas?
Headache
Palpitations
Diaphoresis
Pheochromocytoma symptoms can be chronic or paroxysmal. If chronic, what risk is the patient at risk for?
Cardiomyopathy
What histo item is used to describe Pheochromocytomas?
Zellballen
How can you diagnose a Pheochromocytoma?
Urine/Serum Metanephrines
A Myelolipoma is another tumor of the Adrenal Medulla. Benign or Malignant?
Benign
What is a Myelolipoma made of?
Bone marrow
Fat
Myelolipomas are made of bone marrow and fat. How can they present?
Hemorrahge
MEN stands for?
Multiple Endocrine Neoplasia
Where is the mutation with MEN1?
Tumor suppressor loss of function MEN1 (menin)
What is found with MEN1?
Pituitary Adenoma
Pancreatic Endocrine Tumor
Parathyroid Adenoma
What is found with MEN1?
Pituitary Adenoma
Pancreatic Endocrine tumor
Parathyroid Adenoma
Duodenal Gastrinomas can also be seen with which MEN?
MEN1
Where is the mutation with MEN2A?
Gain of function in RET proto-oncogene
What is found with MEN2A?
Parathyroid Adenoma
Pheochromocytoma
Medullary Thyroid Carcinoma
What is found with MEN2A?
Parathyroid Adenoma
Pheochromocytoma
Medullary Thyroid Carcinoma
Where is the mutation with MEN2B?
Gain of function point mutation in RET proto-oncogene
What is found with MEN2B?
Pheochromocytoma
Medullary Thyroid Carcinoma
Mucosal Neuromas
Marfanoid body habitus
