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ENRP - Exam 2 > Pancreatic Neuroendocrine Tumors > Flashcards

Pancreatic Neuroendocrine Tumors Flashcards

1
Q

All pancreatic neuroendocrine tumors will look like?

A

Solid yellow-tan mass

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2
Q

Where do PAN-NETs have a predilection for?

A

Pancreatic neck and tail

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3
Q

Describe the differentiation and what is present in PAN-NETs?

A

Well differentiated with secretory granules

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4
Q

GEP-NET

A

Gastroenteropancreatic Neuroendocrine Tumors

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5
Q

PAN-NET

A

Pancreatic Neuroendocrine Tumors

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6
Q

Insulinomas affect what cells?

A

Beta cell

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7
Q

Which of the tumors have the lowest metastatic rate?

A

Insulinoma

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8
Q

What will be present on histo with Insulinomas?

A

Amyloid

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9
Q

What can aide in diagnosis of an Insulinoma?

A

C-peptide

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10
Q

What is the symptom of an Insulinoma?

A

HYPOglycemia

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11
Q

If a patient presents with hypoglycemia, what tumor can you suspect?

A

Insulinoma

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12
Q

Gastrinomas affect what cell?

A

G cell

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13
Q

What syndrome is present with Gastrinomas?

A

Zollinger-Ellison

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14
Q

What presents with Gastrinomas?

A

Gastric Acid Hypersecretion and Peptic ULCERS

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15
Q

How will the ulcers respond to therapy with a Gastrinoma?

A

They DONT

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16
Q

Where are the ulcers found with Gastrinomas?

A

Stomach

Duodenum

17
Q

Gastric Acid hypersecretion and peptic ulcers are likely seen with what tumor?

A

Gastrinoma

18
Q

Somatostatinoma affect what cells?

A

Delta cells

19
Q

Which 2 tumors have the highest metastatic rate?

A

Somatostatinoma

VIPoma

20
Q

How will Somatostatinomas present?

A

Cholelithiasiis
DM
Steatorrhea

21
Q

How will Somatostatinomas present?

A

Cholelithiasis
DM
Steatorrhea

22
Q

How does Somatostatinomas cause their symptoms?

A

Inhibiitory function

  • Decrease insulin
  • Decrease gallbladder motility
  • Decrease exocrine pancreas secretions
23
Q

Glucagonomas affect what cell?

A

Alpha cell

24
Q

What are the 2 main symptoms of a Glucagonoma?

A

Hyperglycemia

Rash

25
Q

What is the rash called with a Glucagonoma?

A

Necrolytic Migratory Erythema

26
Q

What are the 4D’s of a Glucagonoma?

A

Depression
DVT
Dermatitis
Diabetes

27
Q

VIPomas affect what cell?

A

D1 cells

28
Q

D1 cells control?

A

Intestinal fluid secretion

29
Q

What will present with a VIPoma?

A

WDHA

= watery diarrhea, hypokalemia, achlorhydria

30
Q

What will present with a VIPoma?

A

WDHA

= Watery diarrhea, hypokalemia, achlorhydria

ENRP - Exam 2 (21 decks)

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