Pediatric Endocrine Flashcards

1
Q

What does a single point on a growth curve tell you?

A

How they plot on the curve on THAT DAY

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2
Q

Multiple points on a growth curve are needed to evaluate the growth pattern. What does that assess?

A

If the rate of growth is adequate!

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3
Q

How many points on a growth curve do you need to assess if the rate of growth is adequate?

A

MULTIPLE

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4
Q

Normal BMI

A

18.5 - 24.9

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5
Q

What is the normal linear growth rate for kids between 5 - puberty?

A

5 cm per year

2 inches per year

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6
Q

What growth parameters is the first to be affected in endocrine disorders?

A

Height/Length

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7
Q

What defines Delayed Bone Age?

A

Bone age is > 2 SD BELOW the chronologic age

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8
Q

What are the 4 parameters on a growth chart?

A

Height/Length
Weight
BMI
Head circumference

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9
Q

When should you be concerned when you are looking at a growth chart?

A

When points plotted start to deviate up or down from normal growth rate for that child

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10
Q

If the height starts to deviate up or down, what should you consider?

A

Endocrine disorder

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11
Q

If the weight starts to deviate up or down, what should you consider?

A

Calories or nutrition issues

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12
Q

If the head circumference starts to deviate up or down, what should you consider?

A

Brain, skull, hydrocephalus

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13
Q

What defines Short Stature?

A

Height is > 2 SD BELOW mean for age/sex

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14
Q

Short Stature is below what percentile?

A

3rd percentile

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15
Q

What is seen with Familial Short Stature?

A

Parents are small

- Child grows with normal velocity but is simply lower on the curve

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16
Q

Familial Short Stature end height?

A

Mid-parental height

17
Q

What is the Bone Age with Familial Short Stature?

A

Bone age is consistent with chronological age

18
Q

What is seen with Constitutional Short Stature?

A

Plotting low on the growth curve and puberty is delayed

19
Q

With Constitutional Short Stature, what will be in the family history?

A

Late bloomers – delayed puberty and growth

20
Q

With Constitutional Short Stature, when will growth and puberty occur? End height?

A

LATER than normal

– End height = normal

21
Q

What is the Bone Age with Constitutional Short Stature?

A

Bone age is DELAYED

22
Q

What is the Bone Age with Idiopathic Short Stature?

A

Bone age is consistent with chronological age

23
Q

If a child presents with short stature, what are 2 things to measure?

A

IGF-1

IGFBP-3

24
Q

If a child presents with short stature, what are 2 things to measure and what are they?

A
IGF-1 = mediator of GH
IGFBP-3 = blood transport protein for IGF-1
25
With short stature due to GH deficiency, what are the levels of IGF-1 and IGFBP-3?
LOW
26
If IGF-1 and IGFBP-3 are both LOW what should be suspected?
GH deficiency
27
What should be performed next after LOW levels of IGF-1 and IGFBP-3 are found?
GH stimulation testing
28
What are 3 GH stimulation tests?
1. Administer Glucagon 2. Administer Arginine 3. Insulin induced hypoglycemia
29
What does linear growth depend on?
Balance between proliferation and deterioration of chondrocytes at the growth plate
30
What does linear growth depend on?
Balance between proliferation and deterioration of chondrocytes at the growth plate
31
What is a major prerequisite for normal bone maturation?
T3
32
What is a regulator of post-natal growth, skeletal maturation, bone and mineral metabolism?
T3
33
T3 is a major prerequisite for?
Normal bone maturation