Pathology Exam 2 Flashcards
types of cellular reaction to any type of injury
???
2 types of reversible tissue changes
progressive tissue changes
regressive tissue changes
this reversible tissue change usually implies an increase in size
progressive tissue change
this reversible tissue change usually implies a decrease in size
regressive tissue change
an irreversible change to injury
death
Regressive changes (4 types)
Degeneration (intracellular)
Infiltration (intercellular)
Necrosis
Atrophy
type of regressive tissue change in which we have the accumulation or buildup of a substance intracellularly within the protoplasm of cells.
Degeneration
Types of degeneration
(a) Cellular (cloudy) swelling -
(b) Fatty degeneration -
(c) Amyloid disease - .
most common type of degeneration. Similar to edema (excess amounts of tissue fluids which bathe and surround the body cells.) This fluid is between cells. Intracellular, cloudy swelling. The swelling would be transient or temporary.
Cellular (cloudy) swelling -
fatty change - fatty metamorphosis – build up or accumulation of fat within the protoplasm of normal cells. Fat in the liver cells affects the liver.
Liver dysfunction
Fatty degeneration
accumulation or buildup of amyloid, a waxy starch-like substance within the normal protoplasm of cells. The amyloid is being deposited within the protoplasm of normal cells
Amyloid disease
Two most common types of amyloid diseases reported:
TB - Typically, in adults, it begins in the lungs.
Osteomyelitis – inflammation of the spongy bone marrow inside bones.
a type of regressive tissue change, in which we have an accumulation or buildup of a substance between the cells
Infiltration (intercellular)
What is the difference between degeneration and infiltration?
where the substances are being deposited
a type of infiltration; the accumulation of pigmented or colored substance between cells.
Pigmentation
pigmentation originated outside the body
Exogenous
a color change along the gum line due to lead
plumbism
black lung disease
anthracosis
the active ingredient of pepto-bismol will cause color change in the small intestines
bismuth poisoning
abnormal buildup of a pigmented or colored substance naturally produced within the body, e.g. jaundice, freckles, moles.
Endogenous
abnormal accumulation or buildup of calcium salts between cell fibers, as in sclerotic vessels, the way the body heals bone fractures.
Calcification
calcareous infiltration
abnormal accumulation or excess of uric acid, especially seen in the big toe
Gout
types of infiltration (3)
pigmentation
calcification
gout
another name for birthmarks
Albenism (albino)
a type of regressive tissue change where there is a localized area of dead tissue in the living body.
Necrosis
causes of necrosis (4)
(1) Insufficient blood supply.
(2) Physical agent - temperature extremes, radiation.
(3) Chemical agents
(4) Loss of nerve supply
types of necrosis (3)
(1) Caseous necrosis
(2) Gangrene
(3) Decubitus ulcer
a type of necrosis - Cheeselike in appearance as seen in T.B.
Caseous necrosis
ischemic necrosis plus putrefaction
gangrene
reduction in arterial blood supply.
Ischemic
the decomposition of proteins in an anaerobic environment (absence of oxygen).
Putrefaction
organisms that obtain their food from dead matter
Saprophytes
commonly called true gangrene – The foreword definition is ischemic necrosis plus putrefaction, since saprophytes are present; foul odor present; no line of demarcation between dead tissue and functional tissue. This type of gangrene spreads very quickly.
moist gangrene
In humans, moist gangrene is most common where?
extremities or the viscera (organs)
false gangrene; no saprophytes present; no order; nice line of demarcation. This type of gangrene spreads slowly.
dry gangrene
only gangrene that is infectious in nature, caused by Clostridium perfringens (a bacteria which can cause spores) during life; microorganisms causes tissue gas in death.
gas gangrene
types of gangrene (3)
moist
dry
gas
type of necrosis; commonly called bedsores which are caused by pressure points which restrict blood flow. (Most commonly seen in bed ridden patients.) They don’t respond well to vascular embalming.
Decubitus ulcer
a type of regressive change; absence or lack of growth. A decrease in size of a body part or organ that previously was of normal size. (shrink)
atrophy
types of atrophy (2)
physiological atrophy
pathological atrophy
a type of atrophy; a decrease in size of a body part or organ due to decreased functional demands
physiological atrophy
an example of physiological atrophy; located at the base of the neck. Largest and most active during infancy. (T-cell lymphocytes)
thymus gland
the progressive shrinkage of all organs as part of the natural aging process
senile atrophy
All ______ will atrophy or shrink as a part of the natural aging process
organs
another example of physiological atrophy; reduction in breast size after lactation
*
decrease in size of a body part or organ due to disease – (emaciation) anorexia nervosa; cancer; disuse. Disease of a body part (muscle) which will decrease in size
pathological atrophy
the body’s total response to any injury
inflammation
functions of inflammation
protection of the body, if possible -
a. Destroy the causative agent.
b. Limit the area affected.
c. Begin the process of repair - the process to replace destroyed cells with new ones (scar tissue), but not the same as the destroyed cells.
Causes of inflammation
a. Physical irritants - extremes of temperature - hot or cold.
Radiation which is cumulative.
b. Chemical irritants - an exposure to chemical.
c. Infectious agents - any type of microscopic pathogens.
d. Immunological reactions - allergic reaction to a immunological shot (autoimmune disease).
Process of inflammation
a. Hyperemia (congestion)
b. Exudation
vascular. Excess blood to the injured body part or organ. The first phase in the inflammatory process. Whole blood is shipped to area of injury by the arteries. Ship whole blood to area of injury first.
Hyperemia (congestion)
The second phase of the inflammatory process. The oozing of fluids at the level of the capillaries.
Exudation
the liquid that is oozed at the level of the capillaries
exudate
Three types of exudates
Purulent (suppurative)
Hemorrhagic
Serous
Exudates which contain pus (dead and living white blood cells and dead and living bacteria).
Purulent (suppurative)
exudate which contains blood.
Hemorrhagic
exudate which does not contain pus.
Serous
An outstanding feature of serous
blisters
Cardinal signs and/or symptoms of inflammation – (Mr. Vesless) these should be temporary.
Heat Redness Swelling Pain Altered function
Latin word meaning heat
calor
Latin word meaning redness
rubor
Latin word meaning swelling
tumor
Latin word meaning pain
dolor
Latin word meaning altered function
functio laesa
Inflammatory lesions (8)
a. Abscess
b. Phlegmon - cellulitis,
c. Vesicle
d. Furuncle
e. Carbuncles
f. Fistula
g. Ulcer
h. Pustule
localized collection of pus.
abscess
a diffuse or wide spread inflammation of subcutaneous connective tissue. Usually appears as a red streak that is spreading rapidly just beneath the surface of the skin. (not to be confused with Bourbon nose)
Phlegmon
cellulitis
medical name for blister, a slight elevation on the surface of the skin filled with serous or non-purulent fluid (does not contain pus); usually caused by second degree burns due to hot liquids or pressure points
Vesicle
single non-communicating boil, a boil is the name commonly given to an abscess of a hair follicle or sweat gland. (Acne, pimple, zit, white head)
Furuncle
several communicating boils where the drainage of the hair follicle or sweat gland are shared.
Carbuncles
abnormal passageway. The most common site is the large intestine. Can occur between parts of a body or from a body part to the outside
Fistula
localized area of necrotic epithel
ulcer
three common sites for ulcers
- Upper GI tract, stomach or duodenum
- Toes on diabetics
- Decubitus ulcer - bedsore
elevation of the surface of the skin which contains pus. (Pimple, whitehead, or black head) usually an oil gland.
Pustule
Acne, pimple, zit, white head are examples of
furuncle
Pimple, whitehead, or black head are examples of
pustule
the outcome of the inflammation phase (3)
- Resolution
- Regeneration
- Repair
part of the outcome of inflammation phase which signals an end of the exudation stage or inflammation stage.
resolution
Two basic methods by which your body completes inflammation
Regeneration
Repair
the replacement of damaged or diseased cells with the exact same type of tissue
Regeneration
two types of regeneration
a. Physiological Regeneration
b. Pathological Regeneration
the replacement of damaged or diseased cells with the exact same type of tissue; due to increased functional demand.
Physiological Regeneration
the replacement of damaged or diseased cells with the exact same type of tissue; due to disease (example: damage or disease of the skin, specifically burns)
Pathological Regeneration
connective tissue cells. The replacement of damaged or diseased tissue with healthy new cells; most commonly connective tissue cells or by surgery – This results in scar tissue.
Repair
Nervous system inflammation
Encephalitis Myelitis Meningitis Poliomyelitis Neuritis
inflammation of the brain
encephalitis
inflammation of the spinal cord
myelitis
inflammation of the 3 layer membrane of the brain and spinal cord
meningitis
inflammation of the gray matter portion of the spinal cord.
Poliomyelitis
inflammation of a neuron or nerve cell
Neuritis
Respiratory system inflammation
Rhinitis Pharyngitis Sinusitis Laryngitis Pleuritis (pleurisy) Tracheitis Bronchitis Pneumonitis (pneumonia)
inflammation of the nasal mucosa (mucusmembrane of the lining of the nasal cavity) nose.
Rhinitis
inflammation of the pharynx - a sore throat.
Pharyngitis
inflammation of one or more sets of the paranasal sinuses. (near or along the nasal cavities)
Sinusitis
inflammation of the larynx or voice box.
Laryngitis
inflammation of the pleura - a thin membrane that surrounds the lungs. (pleural space or cavity)
Pleuritis (pleurisy)
inflammation of the trachea or windpipe.
Tracheitis
inflammation of one or both of the bronchi (two) or bronchus (one)
Bronchitis
inflammation of or infection of lung tissue itself.
Pneumonitis (pneumonia)
3 types of Pneumonitis (pneumonia)
(1) lobar pneumonia - one portion of the lung.
(2) bronchial pneumonia
(3) viral pneumonia
Digestive system inflammation
Stomatitis Glossitis Gingivitis Esophagitis Gastritis Enteritis Diverticulitis Colitis
Proctitis
Peritonitis
Pancreatitis
Hepatitis
Cholecystitis
Cholangitis
Appendicitis
inflammation of the mouth
Stomatitis
inflammation of the tongue
Glossitis
inflammation of the gums
Gingivitis
inflammation of the esophagus - the muscular tube that conveys food from the throat to the stomach
Esophagitis
inflammation of the stomach
Gastritis
inflammation of the small intestines.
Enteritis
inflammation of the diverticulum or intestinal hernia
Diverticulitis
inflammation of the colon - the longest division of the large intestines
Colitis
inflammation of the rectum
Proctitis
inflammation of the peritoneum - the membrane which surrounds the abdominal viscera.
Peritonitis
inflammation of the pancreases - a heterocrine gland
Pancreatitis
inflammation of the liver
Hepatitis
inflammation of the sac containing bile or gallbladder.
Cholecystitis
inflammation of one or more of the bile duct
Cholangitis
inflammation of the vermiform (snakelike) appendix.
Appendicitis
2 types of colitis
(1) amebic
2) ulcerative (psychosomatic disorder
functions of pancreas
- break downs food
2. insulin – released into blood to control sugar levels.
Genitourinary System inflammation
Pyelitis Pyelonephritis Glomerulonephritis Ureteritis Cystitis Urethritis Orchitis Prostatitis Oophoritis Salpingitis Endometritis Endocervicitis Vaginitis
inflammation of the renal pelvis.
Pyelitis
inflammation of the structural and functional unit of the kidney caused by pyogenic pus forming bacteria.
Pyelonephritis
inflammation of the little tufted capillaries (glomerulus) of the structural and functional unit of the kidneys.
Glomerulonephritis
inflammation of the tube that urine between the kidney and urinary bladder conveys.
Ureteritis
inflammation of the urinary bladder.
Cystitis
inflammation of the single tube that conveys urine from the urinary bladder to outside the body.
Urethritis
inflammation of one or both of the male gonads (testis).
Orchitis
inflammation of the prostate gland.
Prostatitis
inflammation of one or both of the ovaries (female sex gland).
Oophoritis
inflammation of one or both of the fallopian tubes.
Salpingitis
inflammation of the endometrium, the inner most or vascular layer of the uterus
Endometritis
inflammation of the endocervic the inner most layer of the lower neck structure of the cervix.
Endocervicitis
inflammation of the Vagina or birth canal.
Vaginitis
Cardiovascular System inflammation
Pericarditis Myocarditis Endocarditis Arteritis Phlebitis . Thrombophlebitis Cholangitis
inflammation of the pericardium - the sack surrounding the heart. (Pericardium- sack surrounding the heart)
Pericarditis
inflammation of the muscle layer of the heart. (Left ventricle has the greatest thickness of myocardium)
Myocarditis
inflammation of the endocardium inner most layer of the heart. Layer of the heart in which heart valves are made. (Endocardium- innermost layer of the heart)
Endocarditis
inflammation of the artery - Angiogram can cause arteritis.
Arteritis
inflammation of the vein
Phlebitis
inflammation of the vein because of the presence of an attached blood clot during life. This clot is called a thrombus.
Thrombophlebitis
inflammation of a vessel (passageway) through which bile flows (one or more of the bile ducts.)
Cholangitis
Skin and Skeletomuscular System inflammation
Dermatitis
Bursitis
Osteomyelitis
Arthritis
inflammation of the skin – Most common form is contact dermatitis ex: poison ivy, poison oak, or poison sumac.
Dermatitis
inflammation of the bursa - the tiny sac filled with a lubricant for the joints. Bursa- tiny sac filled with a lubricant for the joints.
Bursitis
inflammation of the spongy bone marrow
Osteomyelitis
inflammation of the joints
Arthritis
Lymphatic System inflammation
Tonsilitis
Lymphangitis
inflammation of the one or more of the three sets of tonsils. Tissue between the mouth and throat.
Tonsilitis
inflammation of the lymph vessel.
Lymphangitis