Pathology Case-Based Review (2)

Question 1

What are the two kinds of drug-induced liver injury?

Answer 1

• Intrinsic: predictable, dose-dependent

- Idiosyncratic: unpredictable, not dose-dependent

Question 2

What kind of necrosis does acetaminophen cause?

Answer 2

Coagulative

Question 3

Acute HCV is ___________.

Answer 3

most often asymptomatic

Question 4

Elevated serum IgG is found in ______________.

Answer 4

autoimmune hepatitis

Question 5

Elevated serum IgM is found in ______________.

Answer 5

primary biliary cirrhosis (first association) and PSC

Question 6

Granulomatous lymphocytic cholangitis is a characteristic of ____________.

Answer 6

PBC

Question 7

List three examples of hepatocyte neoplasms.

Answer 7

• hepatocellular carcinoma
• hepatocellular adenoma
• focal nodular hyperplasia

Question 8

Hepatocellular adenoma is more common in which gender? What modifiable risk factor also increases risk of HA?

Answer 8

Females; oral contraceptives

Question 9

Thickened hepatic plates with unpaired arteries are characteristic of __________.

Answer 9

hepatocellular carcinoma

Question 10

Normal hepatic plates with unpaired arteries are characteristic of ________________.

Answer 10

hepatocellular adenoma

Question 11

The histologic features of cholangiocarcinoma are _____________.

Answer 11

gland forming with marked desmoplasia

Question 12

The most common benign or malignant liver neoplasm is _________.

Answer 12

hemangioma (2% of the population)

Question 13

Central scar with malformed blood vessels are characteristic of _____________.

Answer 13

focal nodular hyperplasia

Question 14

Cholangiocarcinoma is proliferation of __________.

Answer 14

bile duct cells

Question 15

What is caput medusae?

Answer 15

Blood vessels that radiate out from the belly that look like Medusa’s head

Question 16

“Plasma cell hepatitis” is another way of describing _______________.

Answer 16

autoimmune hepatitis