Adrenal Pharmacology Flashcards

1
Q

The most common cause of secondary adrenal insufficiency is _____________.

A

pharmacologic doses of glucocorticoids

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2
Q

Among steroids, the ___________ effects can be separated from ___________ effects.

A

anti-inflammatory; mineralocorticoids

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3
Q

Which two steroids (of the ones listed in Dr. French’s chart) have no salt-retaining effects?

A

Triamcinolone and dexamethasone

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4
Q

Where is the cellular receptor for glucocorticoids?

A

In the cytosol, but it moves into the nucleus upon binding

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5
Q

Cortisol stimulates contrary processes in the liver. Explain.

A

It stimulates gluconeogenesis and glycogen synthesis.

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6
Q

The kidney has the enzyme _____________ to allow it not be affected by the mineralocorticoid function of cortisol.

A

11-beta hydroxysteroid dehydrogenase

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7
Q

Which adrenal hormones will be absent in 21-hydroxylase deficiency?

A

Aldosterone and cortisol

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8
Q

Without 17-alpha hydroxylase you don’t get _____________.

A

cortisol or androgens

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9
Q

Describe the three pharmacologic things you can do for those with pheochromocytoma.

A

Alpha-blockade
Beta-blockade (once alpha blockade is sufficient)
Calcium channel blockers (for inadequate BP control)

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10
Q

There are two kinds of 11-beta hydroxysteroid dehydrogenase. Which is deactivating?

A

11-B HSD2

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11
Q

Lack of 17-alpha dehydrogenase results in what clinical picture?

A

Non-virilizing hypertension

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12
Q

Lack of 21 hydroxylase results in what clinical picture?

A

Virilizing hypotension

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13
Q

Lack of 11-beta hydroxylase results in what clinical picture?

A

Virilizing hypertension

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