Case-Based Review of Lipid Metabolism

Question 1

True or false: fat oxidation precedes carbohydrate oxidation as exercise intensity increases.

Answer 1

True

Question 2

Geranyl is an intermediate in the synthesis of ____________.

Answer 2

cholesterol

Question 3

True or false: thyroid hormone comes from cholesterol.

Answer 3

False.

Question 4

The two cases that warrant high-intensity statins are _____________.

Answer 4

ASCVD and LDL greater than 190

Question 5

The main difference between moderate and moderate/high intensity statins is ___________.

Answer 5

presence of diabetes indicates moderate/high, while no diabetes but 7.5% CVD risk indicates moderate

Question 6

ABCA1 defects present with ______ HDL.

Answer 6

low

Question 7

Lipoprotein lipase defects present with __________.

Answer 7

sky-high triglycerides

Question 8

Equally elevated triglycerides and LDL suggest a disorder that might present with what physical exam finding?

Answer 8

Xanthomas (being ApoE defect, which leads to inability to retrieve IDLs)

Question 9

True or false: saturated fat is more likely to induce atherosclerosis than trans fat.

Answer 9

False. Trans fat is worse.

Question 10

The Mediterranean diet has been shown to reduce risk of developing ___________.

Answer 10

CVD and diabetes

Question 11

What is the DPP diet?

Answer 11

The diabetes prevention program diet: a low-fat, calorie restricted diet shown to prevent diabetes

Question 12

What kinds of studies have shown that lower saturated fats decrease risk of CVD?

Answer 12

Randomized controlled trials