Pathologies of Malignant Breast Lesions

Question 1

What is the most common cancer in women?

Answer 1

Breast carcinoma

Question 2

What are the three major biologic subgroups of breast carcinoma?

Answer 2

ER-positive, HER2-negative; HER2-positive, ER-positive or ER-negative; ER-negative, HER2-negative

Question 3

What is the most important prognostic factor for invasive breast carcinoma?

Answer 3

Axillary lymph node status

Question 4

What is the main mammographic sign of breast carcinoma?

Answer 4

Densities and calcifications (microcalcifications)

Question 5

What is the most common type of invasive breast carcinoma?

Answer 5

Invasive ductal carcinoma (75-80% of breast carcinoma)

Question 6

What is the typical age range for male breast cancer diagnosis?

Answer 6

Between 60 and 70 years

Question 7

What is the most common cause of pathologic nipple discharge?

Answer 7

Intraductal papilloma (57% of cases)

Question 8

What is the most common location for invasive breast carcinoma?

Answer 8

Upper outer quadrant

Question 9

What is the most common molecular subtype of breast cancer?

Answer 9

Luminal A (40-50% of breast cancer)

Question 10

What is the primary treatment for male breast cancer?

Answer 10

Surgery, radiotherapy, and hormonal medication