Pathogenesis of microbial infections Flashcards

1
Q

What type of parasite replicates within host cells?

A

obligate intracellular parasite

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2
Q

What type of parasite replicates outside of a cell?

A

facultative parasites

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3
Q

What is the most common bacteria in resident skin flora

A

Staph. epidermidis

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4
Q

What is the most common bacteria in transient skin flora

A

Staph. aureus

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5
Q

What is an opportunistic infection

A

when non-pathogenic organism acts as a pathogen

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6
Q

What is immunopathogenesis

A

primary cause of cell death in infections - killing of cells by host immune system

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7
Q

What is the difference between signs and symptoms

A

Symptoms are experienced, signs are measured

Like thirst, lethargy etc are symptoms of diabetes; high blood sugar is a sign of diabetes

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8
Q

What is the prodromal stage of a disease?

A

stage in which non-specific symptoms occur

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9
Q

What is a sporadic disease

A

disease which only occurs occasionally like tetanus

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10
Q

What is an endemic disease

A

disease continuously present in a population like chickenpox

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11
Q

What is an epidemic disease

A

disease has greater number of cases than normal in an area like SARS in 2003

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12
Q

What is a pandemic disease

A

epidemic disease with worldwide distribution like the flu pandemic

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13
Q

What is the difference between a latent and chronic infection

A

Latent: reactivation which is symptomatic or asymptomatic
Chronic: continued production of infectious organism

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14
Q

What is a nosocomial infection

A

Infection acquired in hospital

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15
Q

What does MRSA stand for

A

methicillin resistant Staph. aureus

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16
Q

What does VREF stand for

A

vancomycin resistant Enterococeus faeciais

17
Q

What does CPE stand for

A

carbapenemase producing enterobacterieae

18
Q

What are adhesins on the surface of a bacteria?

A

Proteins/glycolipids/polysaccharides which are on the surface of a bacteria which bind to receptors on the host cell surface

19
Q

What are attachment factors and give an example

A

help concentrate viral particles at the cell surface, such as heparin sulfate proteoglycans

20
Q

What is host range

A

different species of hosts a given pathogen can infect

21
Q

What is tissue tropism

A

different tissues within an organism that are infected by the pathogen (eg rhinovirus affecting the resp. tract)

22
Q

What is LD50

A

lethal dose 50; number of pathogens needed to kill 50% of hosts

23
Q

What is ID50

A

infectious dose 50; number of pathogens needed to infect 50% of hosts

24
Q

In which kind of bacteria are endotoxins present

A

in the cell walls of Gram-neg bacteria

25
Q

In which kind of bacteria are exotoxins present

A

secreted by Gram-pos bacteria

26
Q

What are superantigens?

A

toxins that stimulate the immune system; bind to MHCII molecules nonspecifically so activate a large number of T-cells