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.pathology > Parasites, Prions and Fungi Toxins of CNS > Flashcards

Parasites, Prions and Fungi Toxins of CNS Flashcards

1
Q

Dimorphic yeast

A

Coccidiodes immitis
Blastomyces dermatidis
Cyrptococcus neoformans
Histoplasma capsulatum

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2
Q

Aspergillosis

A

Most common fungal infection, opportunistic
A. fumigatus most common, A. flavus- alfatoxicosis (moldy food → liver dz), A. terreus (german sheps)

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3
Q

Protothecosis

A

Algae associated with immunosuppression
Disseminated illness, colonic protothecosis (initial presentation)

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4
Q

Paralephastrongylus tenuis

A

Meningeal worm
Deer definitive host, gastropod intermediate
Severe signs and mortality in aberrant ruminant hosts

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5
Q

Equine protozoal myeloencephalitis

A

From sarcocystis neurona
Varying neurologic signs, SC most severely infected
Horses dead end host, possums spread

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6
Q

Toxoplasma Gondii

A

Cast most commonly have clincal dz
Dogs CS= immunosuppression
Transplacentally affects kittens, zoonotic

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7
Q

Neosporum caninum

A

Usually subclinical, puppies may have hindlimb paresis
Adults get immunosuppression
Abortion in ruminants

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8
Q

Encephalitozoonosis

A

Encephalitozoon cuniculi
Rabbits mostly affected
Affects the kidney, ocular and CNS

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9
Q

Encephalitozoonosis transmission

A

Excreted from urine → ingestion or inhalation
Vertical transmission in utero

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10
Q

Encephalitozoonosis CS

A

Head tilt, hindlimb paresis, vestibular dz symptoms

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11
Q

Aberrant migration

A

Larval migration (visceral larva migrans: toxocara canis)
Cuterebra sp. (Feline ischemic encephalopathy)

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12
Q

Aberrant migration of tapeworms

A

Echinococcus granulosus and E. multilocularis
Cysticercus (T. solium- pig and T. saginata- bovine)

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13
Q

Echinococcosis

A

E. granulosus and E. multilocularis
Dogs definitive hosts (no CS)
Incidental hosts get hydatid cysts in diff organs

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14
Q

Cysticercosis

A

Ingestion of infective eggs of Taenia spp. tapeworms→ cysticerci develop in the m. of intermediate host
Fecooral transmission of eggs of undercooked meat

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15
Q

PRNP

A

Gene where your DNA encodes for prion protein

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16
Q

Prion protein (PrP)

A

Protein on the surface of your cells

17
Q

Prion

A

Infectious particle made up of misfolded prion proteins

18
Q

Prion protein diseases are known as __________-

A

Transmissible spongiform encephalopathies

19
Q

Prion protein diseases

A

Bovine spongiform encephalopathy
Transmissible Mink encephalopathy
Scrapie- sheep
Chronic wasting disease- deer

20
Q

Prion protein dz CS

A

Progressive wasting, neurologic signs, altered behavior, pruritus
Dx: ELISA (obex)

21
Q

Microscopic lesions of prion protein dz

A

Large vacuoles in cytoplasm of neurons (gliosis)
Limited to medulla, pons, midbrain and SC
Bilaterally symmetrical

.pathology (20 decks)

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