PAN (Classic Macroscopic Polyarteritis Nodosa)

Question 1

Classic PAN is a systemic necrotizing vasculitis primarily affecting what size of muscular arteries?

Answer 1

MEDIUM-SIZED

Question 2

What is the gender predominance in PAN?

Answer 2

MALES

Question 3

What si the peak incidence of PAN?

Answer 3

5th-6th decade

Question 4

What is the most common associated illness found in patients with classic PAN?

Answer 4

HBV INFECTION

Question 5

What are the 2 other conditions that are associated with classic PAN?

Answer 5

1. AMPHETAMINE ABUSE
2. HAIRY CELL LEUKEMIA

Question 6

What organ is commonly affected in PAN?

Answer 6

KIDNEYS

Question 7

ANCA in PAN is?

Answer 7

NEGATIVE

Question 8

what are the 2 clinical features of classic PAN?

Answer 8

1. ANCA NEGATIVE
2. VISCERAL ORGAN INFARCTION/ISCHEMIA

Question 9

What is the renal manifestations in classic PAN which is due to predominant involvement of the larger vessel?

Answer 9

RENAL ISCHEMIA/INFARCTION

Question 10

What are the medications used int he treatment of PAN?

Answer 10

1. CORTICOSTEROIDS
2. CYCLOPHOSPHAMIDE
3. AZATHIOPRINE
4. ANTIVIRAL AGENTS (In HBV)

Question 11

What is the most effective agent in the treatment of PAN?

Answer 11

CYCLOPHOSPHAMIDE

Question 12

What is the usual regimen used in the initial therapy for PAN?

Answer 12

CYCLOPHOSPHAMIDE
(high dose: 2mkd)
+++ PLUS +++
CORTICOSTEROIDS
(high dose: 1 mkd)

Question 13

What is the regimen for the treatment of PAN associated with HBV & Hairg Cell Leukemia?

Answer 13

1st: CORTICOSTEROIDS for 2 weeks
Then: ANTIVIRAL AGENTS

Question 14

How many months should immunosuppressive therapy be continued ESKD patients after the disease appears inactive?

Answer 14

6-12 months