GLOMERULAR INVOLVEMENT WITH BACTERIAL INFECTIONS

Question 1

In the preantibiotic era, what is the commonest organism asspciated with infectious endocarditis GN?

Answer 1

Streptococcus viridans

Question 2

In the pre antibiotic era, glomerulonephritis occurred in how many % of subacute endocarditis cases?

Answer 2

50% - 80%

Question 3

With the use of prophylactic antibiotics in patients with valvular heart disease, and an increase in intravenous drug use, what is the primary pathogen that causes IE GN?

Answer 3

Staphylococcus aureus

Question 4

What is the incidence (in %) of glomerulonephritis with endocarditis with S. aureus?

Answer 4

22-78 %

Question 5

What are the TOP 2 most common pathogens associated with IE GN?

Answer 5

1. S. aureus (with methicillin resistance in 56%)
2. Streptococcus sp

Question 6

What are the 4 less common pathogens that cause IE GN? (In order of frequency)

Answer 6

1. Bartonella henselae
2. Coxiella burnetii
3. Cardiobacterium hominis
4. Gemella sp

Question 7

IgA-dominant infection–related GN is associated with what pathogen?

Answer 7

STAPHYLOCOCCUS

Question 8

Predominant IgM staining on IF is associated with what pathogen?

Answer 8

Bartonella endocarditis

Question 9

What are the 3 therapies used in the treatment of IE GN?

Answer 9

1. CORTICOSTEROIDS
2. PLASMAPHERESIS
3. IMMUNOSUPPRESSION

Question 10

What is the most common pathogen associated with ventriculovascular shunts?

Answer 10

Staph. albus

Question 11

What type of shunt is more resistant to infection?

Answer 11

VENTRICULOPERITONEAL SHUNT

Question 12

What is the predominant Ig deposited in shunt nephritis?

Answer 12

IgM

Question 13

What is the most common pattern of GN in syphilis?

Answer 13

MN

Question 14

What is the most common finding of syphilis in IF?

Answer 14

• Granular IgG
• C3 deposits

Question 15

What is the organism responsible for bartonellosis (cat scratch disease)?

Answer 15

Bartonella henselae

Question 16

What disease manifests as a skin papule followed by regional lymphadenopathy?

Answer 16

BARTONELLOSIS or CAT SCRATCH DISEASE

Question 17

What are the 3 renal manifestations of Cat scratch disease?

Answer 17

1. IgAN
2. Postinfectious GN
3. Necrotizing GN

Question 18

What are the 7 kidney biopsy findings in Mycobacterium leprae GN?

Answer 18

1. Mesangial proliferation
2. diffuse proliferative glomerulonephritis
3. crescentic glomerulonephritis
4. MN
5. MPGN
6. microscopic angiitis
7. amyloidosis

Question 19

Aspergillosis has been associated with what type of GN?

Answer 19

IMMUNE-COMOLEX MEDIATED GN

Question 20

What are the 4 patterns associated with Mycobacterium tuberculosis GN?

Answer 20

1. MN
2. MPGN
3. crescentic GN
4. amyloidosis

Question 21

Mycoplasma is associated with what pattern of GN?

Answer 21

1. Nephrotic syndrome
2. RPGN

Question 22

Pneumococcal infection is associated with what pattern of GN?

Answer 22

POSTINFECTIOUS GN

Question 23

Nocardiosis is associated with what type of GN?

Answer 23

MESANGIOCAPILLARY GN

Question 24

What are the 3 patterns of renal injury associated with Leptospira?

Answer 24

1. tubulointerstitial nephritis (mcm)
2. mesangial or diffuse proliferative GN

Question 25

What is the most common renal biopsy finding in Salmonella GN?

Answer 25

Mesangial proliferation with deposits of IgG, C3, and C4

Question 26

What are the 3 most common mesangial deposits in Salmonella?

Answer 26

IgG, C3, and C4