GLOMERULAR INVOLVEMENT WITH BACTERIAL INFECTIONS Flashcards
In the preantibiotic era, what is the commonest organism asspciated with infectious endocarditis GN?
Streptococcus viridans
In the pre antibiotic era, glomerulonephritis occurred in how many % of subacute endocarditis cases?
50% - 80%
With the use of prophylactic antibiotics in patients with valvular heart disease, and an increase in intravenous drug use, what is the primary pathogen that causes IE GN?
Staphylococcus aureus
What is the incidence (in %) of glomerulonephritis with endocarditis with S. aureus?
22-78 %
What are the TOP 2 most common pathogens associated with IE GN?
- S. aureus (with methicillin resistance in 56%)
- Streptococcus sp
What are the 4 less common pathogens that cause IE GN? (In order of frequency)
- Bartonella henselae
- Coxiella burnetii
- Cardiobacterium hominis
- Gemella sp
IgA-dominant infection–related GN is associated with what pathogen?
STAPHYLOCOCCUS
Predominant IgM staining on IF is associated with what pathogen?
Bartonella endocarditis
What are the 3 therapies used in the treatment of IE GN?
- CORTICOSTEROIDS
- PLASMAPHERESIS
- IMMUNOSUPPRESSION
What is the most common pathogen associated with ventriculovascular shunts?
Staph. albus
What type of shunt is more resistant to infection?
VENTRICULOPERITONEAL SHUNT
What is the predominant Ig deposited in shunt nephritis?
IgM
What is the most common pattern of GN in syphilis?
MN
What is the most common finding of syphilis in IF?
• Granular IgG
• C3 deposits
What is the organism responsible for bartonellosis (cat scratch disease)?
Bartonella henselae
What disease manifests as a skin papule followed by regional lymphadenopathy?
BARTONELLOSIS or CAT SCRATCH DISEASE
What are the 3 renal manifestations of Cat scratch disease?
- IgAN
- Postinfectious GN
- Necrotizing GN
What are the 7 kidney biopsy findings in Mycobacterium leprae GN?
- Mesangial proliferation
- diffuse proliferative glomerulonephritis
- crescentic glomerulonephritis
- MN
- MPGN
- microscopic angiitis
- amyloidosis
Aspergillosis has been associated with what type of GN?
IMMUNE-COMOLEX MEDIATED GN
What are the 4 patterns associated with Mycobacterium tuberculosis GN?
- MN
- MPGN
- crescentic GN
- amyloidosis
Mycoplasma is associated with what pattern of GN?
- Nephrotic syndrome
- RPGN
Pneumococcal infection is associated with what pattern of GN?
POSTINFECTIOUS GN
Nocardiosis is associated with what type of GN?
MESANGIOCAPILLARY GN
What are the 3 patterns of renal injury associated with Leptospira?
- tubulointerstitial nephritis (mcm)
- mesangial or diffuse proliferative GN
What is the most common renal biopsy finding in Salmonella GN?
Mesangial proliferation with deposits of IgG, C3, and C4
What are the 3 most common mesangial deposits in Salmonella?
IgG, C3, and C4
