MPA (Microscopic Polyangiitis)

Question 1

What is the most typical histologic finding by LM of MPA?

Answer 1

FOCAL SEGMENTAL NECROTIZING GN WITH CRESCENTS OVERLYING AREAS OF SEGMENTAL TUFT NECROSIS

Question 2

“sunburst” appearance in LM in MPA is due to?

Answer 2

massive circumferential destruction of Bowman’s capsule by voluminous crescents

Question 3

Which has a more prolonged, less fulminant course in patients,
MPA or GPA?

Answer 3

MPA

Question 4

What arteries are predominantly affected in MPA?

Answer 4

INTERLOBAR ARTERIES & ARTERIOLES
(Located in the cortex)

Question 5

What is the most common and intensely staining by IF in MPA?

Answer 5

FIBRIN/FIBRINOGEN

Question 6

What laboratory test is used to diagnose MPA?

Answer 6

ANCA

Question 7

What is the standard treatment for MPA?

Answer 7

1. CORTICOSTEROIDS
2. CUCLOPHOSPHAMIDE

Question 8

What are the 4 therapeutic intervention in addition to immunosuppressive therapy?

Answer 8

1. RAAS BLOCKADE
2. STATINS
3. ANTI-HPN THERAPY
4. LOW CHON DIET