HSP Flashcards
What is the other name of Henoch–Schönlein purpura?
IgA VASCULITIS
HSP is a systemic vasculitic syndrome with involvement of what 3 organs?
- SKIN
- GI
- JOINTS
HSP is a systemic vasculitic syndrome with what type of renal involvement?
GN
What is the result of deposition of IgA-containing immune complexes in the skin?
LEUKOCYTOCLASTIC ANGIITIS WITH PETECCHIAE & PURPURA
What is the 3 results of deposition of IgA-containing immune complexes in the GIT?
- ULCERATIONS
- PAIN
- BLEEDING
What is the result of deposition of IgA-containing immune complexes in the kidney?
IMMUNE-COMPLEX MEDIATED GN
What is the most common gender predilection & peak age in IgA vasculitis?
• MALES
• 5-10 years
What season is usually the peak for IgA vasculitis?
WINTER
What is the classic tetrad of findings in HSP?
- DERMAL INVOLVEMENT
- GI DISEASE
- JOINT INVOLVEMENT
- GN
Skin lesions are almost universal with HSP and are commonly found in which parts of the body?
• LOWER & UPPER EXT
• BUTTOCKS
Which 2 joints are most commonly affected in HSP?
- KNEES
- ANKLE
Renal disease is more frequent and of greater severity in what 2 age groups?
• OLDER CHILDREN
• ADULTS
What is the renal biopsy finding in HSP?
MESANGIAL & ENDOCAPILLARY PROLIFERATIVE GN
What is the dominant Ig by IF of HSP?
IgA
The deposited IgA is usually what subclass?
IgA1
What is the difference of immune deposits in HSP vs SLE?
HSP: IgA dominant
C1q rare
SLE: IgG dominant
C1q always present
What ate the 2 EM findings in HSP?
- ELECTRON DENSE DEPOSITS IN THE MESANGIUM
- INCREASE IN MESANGIAL HYPERCELLULARITY AND MATRIX
HSP and IgAN have high levels of this Ig in their circulation?
GALACTOSE-DEFICIENT IgA
What is the therapy for majority of patients with HSP?
SUPPORTIVE
