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Ch 32 Secondary GN > HSP > Flashcards

HSP Flashcards

1
Q

What is the other name of Henoch–Schönlein purpura?

A

IgA VASCULITIS

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2
Q

HSP is a systemic vasculitic syndrome with involvement of what 3 organs?

A
  1. SKIN
  2. GI
  3. JOINTS
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3
Q

HSP is a systemic vasculitic syndrome with what type of renal involvement?

A

GN

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4
Q

What is the result of deposition of IgA-containing immune complexes in the skin?

A

LEUKOCYTOCLASTIC ANGIITIS WITH PETECCHIAE & PURPURA

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5
Q

What is the 3 results of deposition of IgA-containing immune complexes in the GIT?

A
  1. ULCERATIONS
  2. PAIN
  3. BLEEDING
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6
Q

What is the result of deposition of IgA-containing immune complexes in the kidney?

A

IMMUNE-COMPLEX MEDIATED GN

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7
Q

What is the most common gender predilection & peak age in IgA vasculitis?

A

• MALES
• 5-10 years

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8
Q

What season is usually the peak for IgA vasculitis?

A

WINTER

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9
Q

What is the classic tetrad of findings in HSP?

A
  1. DERMAL INVOLVEMENT
  2. GI DISEASE
  3. JOINT INVOLVEMENT
  4. GN
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10
Q

Skin lesions are almost universal with HSP and are commonly found in which parts of the body?

A

• LOWER & UPPER EXT
• BUTTOCKS

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11
Q

Which 2 joints are most commonly affected in HSP?

A
  1. KNEES
  2. ANKLE
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12
Q

Renal disease is more frequent and of greater severity in what 2 age groups?

A

• OLDER CHILDREN
• ADULTS

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13
Q

What is the renal biopsy finding in HSP?

A

MESANGIAL & ENDOCAPILLARY PROLIFERATIVE GN

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14
Q

What is the dominant Ig by IF of HSP?

A

IgA

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15
Q

The deposited IgA is usually what subclass?

A

IgA1

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16
Q

What is the difference of immune deposits in HSP vs SLE?

A

HSP: IgA dominant
C1q rare

SLE: IgG dominant
C1q always present

17
Q

What ate the 2 EM findings in HSP?

A
  1. ELECTRON DENSE DEPOSITS IN THE MESANGIUM
  2. INCREASE IN MESANGIAL HYPERCELLULARITY AND MATRIX
18
Q

HSP and IgAN have high levels of this Ig in their circulation?

A

GALACTOSE-DEFICIENT IgA

19
Q

What is the therapy for majority of patients with HSP?

A

SUPPORTIVE

Ch 32 Secondary GN (35 decks)

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