MIXED CONNECTIVE TISSUE DISEASE

Question 1

What is the most widely used serologic test to confirm diagnosis of MCTD?

Answer 1

ENA with ANTI-U1RNP ANTIBODIES

Question 2

What 2 genotypes is associated with MCTD?

Answer 2

1. HLA-DR2
2. HLA-DR4

Question 3

What are the 2 the distinct serologic findings in MCTD?

Answer 3

1. ANA TITER (very high)
2. ANTI-U1RNP ANTIBODIES

Question 4

What is the most common pattern of glomerular involvement in MTCD?

Answer 4

MN

Question 5

Whatvare the 2 therapies used in the treatment of MCTD?

Answer 5

1. CORTICOSTEROIDS (for inflammatory features: joint dse and serositis)
2. IVIG (treat thrombocytopenia)

Question 6

What 2 antibodies when present in MCTD increases mortality risk?

Answer 6

1. ANTICARDIOLIPIN ANTIBODIES
2. ANTI-β2GLYCOPROTEIN ANTIBODIES

Question 7

What are the 2 leading causes of mortality in MCTD?

Answer 7

1. PULMONARY HPN
2. CV DISEASE