MIDD

Question 1

What are the 3 types of MIDD?

Answer 1

1. LCDD
2. LHCDD
3. HCDD

Question 2

Wat is the most common pattern of MIDD?

Answer 2

LCDD

Question 3

What is the most common deposits in 80% of patients with LCDD?

Answer 3

κ-light chains (VkIV subgroup)

Question 4

In Amyloid, what region of the light chains are the fibrils derived?

Answer 4

VARIABLE REGION

Question 5

In LCDD the deposits are predominantly composed of what region of the light chain?

Answer 5

CONSTANT REGION

Question 6

What are 5 the medications that are used together with dexamethasone in the treatment of MIDD?

Answer 6

1. CYCLOPHOSPHAMIDE
2. THALIDOMIDE
3. LENALIDOMIDE
4. MELPHALAN
5. BORTEZOMIB

Question 7

What is the creatinine level at initiation of treatment where therapy in MIDD is no longer successful?

Answer 7

> 4mg/dl

Question 8

What are the 2 other treatment options for pxs with LCDD?

Answer 8

1. BONE MARROW TRANSPLANT
2. STEM CELL TRANSPLANT

Question 9

In LM, what is the glomerular pattern in LCDD?

Answer 9

NODULAR SCLEROSING WITH MESANGIAL NODULES

Question 10

In LM, what is the glomerular pattern in HCDD?

Answer 10

NODULAR SCLEROSING GLOMERULOPATHY WITH SMALL CRESCENTS

Question 11

The diagnosis of HCDD is made by?

Answer 11

IF

Question 12

What is the staining in IF in HCDD?

Answer 12

linear positivity for the heavy chain of immunoglobulin (usually gamma)