Palliative Care Flashcards

1
Q

Describe the WHO pain ladder

A
  1. non opiod +/- adjuvant
  2. Mild opioid +/- non opiod +/- adjuvant
  3. Strong opioid +/-nonopiod +/- adjuvant
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2
Q

give examples if mild opiates

A

codeine, tramadol, dihydorcodeine

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3
Q

give examples of strong opiods

A

diamorphine
morphine
fentanyl
oxycodone

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4
Q

what is the CTZ

A

chemoreceptor trigger zone - receives inputs from blood-borne drugs or hormones, and communicates with other structures in the vomiting center to initiate vomiting

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5
Q

where is the CTZ locate

A

on the floor of the fourth ventrical in the medulla

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6
Q

What neurotransmitters are involved in vomiting

A
dopamine
5HT
NK1
GABA
Ach
Opioid
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7
Q

what are the characteristics of vomiting due to impaired gastric emptying

A

not usually nauseated - then suddenly very nauseated - large volume vomits - feels better after vomit

5HT/D2 mediated

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8
Q

What are the characteristics of regurgitation vomiting

A

due to obstruction or compression of the oesophagus - dysphagia, pain, coughing, stridor

5HT/D1 mediated

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9
Q

What are the characteristics of chemical/metabolic reasons for vomiting

A

persistant nausea, little relief from vomiting
(calcium, sodium and urea raised)

CTZ/D1/NK - CTZ mediated
GABA/NK1 - cerebral

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10
Q

characteristics of bowel obstruction vomiting

A

intermittent large vomits, colic, reduced bowel movements

5HT/D2 = gut mediated

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11
Q

characteristics of vomitning due to cerebral disease

A

worse in morning, headache

GABA/H1/NK1 - cerebral

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12
Q

characterisitcs of vestibular vomiting

A

worse on movement, vertigo, tinnitus

Ach/H1 - vestibular

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13
Q

What type of vomiting does oncological treatments produce

A

Cerebral - GABA/NK1

CTZ- 5HT/d2

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14
Q

treatment of vomiting due to impaired gastric emptying

A

metoclopramide

domperidone

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15
Q

treatment of regurgitation vomiting

A

dexamethasone

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16
Q

treatment of chemical/metabolic vomiting

A

haloperidol
metoclompramide
levomepromazine

17
Q

treatment of vomiting due to cerebral disease

A

dexamethasone

cyclizine

18
Q

treatment of vestibular vomiting

A

cyclizine

prochlorperazine

19
Q

treatment of vominting due to oncological treatments

A

ondansetron
metoclopramide
dexamethasone
lorazepam

20
Q

Which part of the bowel is more commonly obstructed in malignant bowel obstruction

A

small intestine> large

21
Q

name drugs that are used as anti secretory agents

A
hyoscine butylbromide (buscopan)
octreotide
22
Q

how does octreotide work

A

it is a sommatostatin analogue - inhibits GI secretions

23
Q

NAME some stool softeners

A

sodium docusate

movicol

24
Q

what laxative should be used if the patient has refractory opioid induced constipation

A

methylnatrexone

25
Q

how should medications generally be delivered in palliation

A

parenteral not oral